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Acta Parasitologica

, Volume 64, Issue 2, pp 390–393 | Cite as

First Molecular Diagnosis of Lophomoniasis: the End of a Controversial Story

  • Mahdi FakharEmail author
  • Maryam Nakhaei
  • Ali SharifpourEmail author
  • Hamed Kalani
  • Elham Sadat Banimostafavi
  • Siavash Abedi
  • Sepideh Safanavaei
  • Masoud Aliyali
Short Communication
  • 22 Downloads

Abstract

Introduction

We report a case of lophomoniasis in an immunocompetent patient with acute paranasal sinusitis from the north of Iran whose disease was diagnosed by both microscopic and molecular methods.

Case Presentation

The patient, a 40-year-old woman, suffered from upper respiratory infection, was referred to the Iranian National Registry Center for Lophomoniasis (INRCL) at the Mazandaran University of Medical Sciences, Sari, Iran, for diagnosis. A direct wet mount of nasal discharge revealed the flagellate protozoa morphologically identified Lophomonas blattarum. Moreover, through a specific polymerase chain reaction (PCR) of nasal discharge, a 214-bp band was observed, confirming the genus Lophomonas spp. The patient was treated successfully with metronidazole 500 mg t.i.d for 1 week.

Conclusion

To the best of our knowledge, this is the first molecular detection of lophomoniasis in the literature. According to our preliminary study, a reliable PCR test is available now for detecting the Lophomonas parasite.

Keywords

Lophomonas Human Sinusitis Molecular diagnosis 

Notes

Acknowledgements

The authors wish to thank Mrs Amiri and Mrs Vafaei-Nezhad for kind contribution in INRCL.

Funding

Financial support for this study was received from the Mazandaran University of Medical Sciences, Sari, Iran (No: 1291).

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Copyright information

© Witold Stefański Institute of Parasitology, Polish Academy of Sciences 2019

Authors and Affiliations

  • Mahdi Fakhar
    • 1
    • 5
    Email author
  • Maryam Nakhaei
    • 1
  • Ali Sharifpour
    • 1
    • 2
    Email author
  • Hamed Kalani
    • 3
  • Elham Sadat Banimostafavi
    • 4
  • Siavash Abedi
    • 2
  • Sepideh Safanavaei
    • 2
  • Masoud Aliyali
    • 2
  1. 1.Toxoplasmosis Research Center, Iranian National Registry Center for Lophomoniasis (INRCL)Mazandaran University of Medical SciencesSariIran
  2. 2.Pulmonary and Critical Care Division, Imam Khomeini Hospital, Iranian National Registry Center for Lophomoniasis (INRCL)Mazandaran University of Medical SciencesSariIran
  3. 3.Infectious Diseases Research CenterGolestan University of Medical SciencesGorganIran
  4. 4.Department of Radiology, Imam Khomeini HospitalMazandaran University of Medical SciencesSariIran
  5. 5.Toxoplasmosis Research Center, School of Medicine, Department of ParasitologyMazandaran University of Medical SciencesSariIran

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