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Acta Parasitologica

, Volume 64, Issue 4, pp 916–922 | Cite as

Clinical and Pathological Aspects of Canine Cutaneous Leishmaniasis: A Meta-analysis

  • Caroline Sobotyk OliveiraEmail author
  • Fabiana Raquel Ratzlaff
  • Luciana Pötter
  • Pedro Roosevelt Torres Romão
  • Sônia de Avila Botton
  • Fernanda Silveira Flores Vogel
  • Luis Antonio Sangioni
Short Communication
  • 40 Downloads

Abstract

Purpose

In the present study, we described the most prevalent clinical symptoms, the most affected organs, and the macro and microscopic lesions associated with cutaneous leishmaniasis.

Methods

Two independent researchers performed an extensive systematic review of the literature in four stages (identification, screening, eligibility, and inclusion) to identify studies published between January 2002 and November 2018 from the following electronic databases: Web of Science, PubMed, SciELO, Science Direct, and Google Scholar. Meta-analysis was conducted in “Metaprop” package of R 3.4.2 software.

Results

The electronic search yielded 3896 results, out of which 155 were further analyzed based on the full-text. Data extracted from 16 articles were included in the meta-analysis, representing a total of 430 leishmaniasis cases. Only 43% of all animals were identified to exhibit the clinical and cutaneous changes characteristic of leishmaniasis based on the observation that skin lesions were the most prevalent clinical sign and were present in 86% of all cases. Other less prevalent symptoms included weight loss, cachexia, apathy and lymph node enlargement. Histopathological analysis showed that the skin was the most affected organ, affecting 64% of cases, followed by lymph nodes (12%), spleen (8%) and liver (7%).

Conclusions

Therefore, our current findings suggest that cutaneous leishmaniasis could lead to visceral disease. Notably, our findings indicated no clinical manifestation patterns in cutaneous leishmaniasis, since the same host species may present different clinical conditions.

Keywords

Leishmania Dog Clinical condition Histopathology Meta-analysis 

Notes

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Copyright information

© Witold Stefański Institute of Parasitology, Polish Academy of Sciences 2019

Authors and Affiliations

  • Caroline Sobotyk Oliveira
    • 1
    Email author
  • Fabiana Raquel Ratzlaff
    • 1
  • Luciana Pötter
    • 2
  • Pedro Roosevelt Torres Romão
    • 3
  • Sônia de Avila Botton
    • 1
  • Fernanda Silveira Flores Vogel
    • 1
  • Luis Antonio Sangioni
    • 1
  1. 1.Programa de Pós Graduação em Medicina Veterinária, Departamento de Medicina Veterinária PreventivaUniversidade Federal de Santa (UFSM)Santa MariaBrazil
  2. 2.Programa de Pós Graduação em Zootecnia, Departamento de ZootecniaUniversidade Federal de Santa (UFSM)Santa MariaBrazil
  3. 3.Laboratório de Imunologia, Departamento de Ciências Básicas da SaúdeUniversidade Federal de Ciências da Saúde de Porto AlegrePorto AlegreBrazil

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