Ethanol Extracts from Thai Plants have Anti-Plasmodium and Anti-Toxoplasma Activities In Vitro
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The ethanol extracts from seven Thai plants, Kaempferia parviflora, Stemona tuberosa Lour., Ananas comosus, Punica granatum, Musa sapientum L., Pseuderanthemum palatiferum and Annona muricata L., which are traditionally used in Thailand to support human health, were evaluated for their anti-Plasmodium and anti-Toxoplasma activities, and for their cytotoxicities against human foreskin fibroblasts in vitro.
The K. parviflora, P. palatiferum and A. muricata extracts were active against P. falciparum (3D7) with selectivity index (SI) values > 10, while their half maximal inhibitory concentrations (IC50) were 28.7 µg/ml, 78.8 µg/ml and 46.1 µg/ml, respectively. Extracts from K. parviflora and M. sapientum (ripe fruit peel) inhibited T. gondii (RH) growth with IC50 values of 53.5 µg/ml and 90.4 µg/ml, respectively. The SI values of the extracts from K. parviflora and M. sapientum (ripe fruit peel) were 9.0 and 10.8, respectively.
Our data show that some of the aforementioned ethanol extracts are potential sources of new drugs to treat Plasmodium and Toxoplasma infections.
KeywordsNatural plants Traditional medicine Plasmodium falciparum Toxoplasma gondii
The authors thank the Faculty of Veterinary Science, Mahidol University for providing the crude plant extracts. Arpron Leesombun was supported by the Special Financial Support Program for International Students of the Doctoral Program of Obihiro University of Agriculture and Veterinary Medicine. We are grateful to S. Kawazu (Obihiro University of Agriculture and Veterinary Medicine) for providing P. falciparum. We thank the Hokkaido Kushiro Red Cross Blood Center for supplying human red blood cells, and Sandra Cheesman, PhD, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript. This research was supported by a grant for the Suhara Memorial Foundation 2017.
Compliance with Ethical Standards
Conflict of interests
The authors declare that they have no conflict of interest.
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