Urinary creatinine to serum creatinine ratio and renal failure index in dogs infected with Babesia canis
Urinary creatinine to serum creatinine (UCr/SCr) ratio and renal failure index (RFI) are useful indices of renal damage. Both UCr/SCr ratio and RFI are used in differentiation between prerenal azotaemia and acute tubular necrosis. In this work the authors calculated the UCr/SCr ratio and RFI in dogs infected with Babesia canis and the values of these indices in azotaemic dogs infected with the parasite. The results of this study showed significantly lower UCr/SCr ratio in dogs infected with B. canis than in healthy dogs. Moreover, in azotaemic dogs infected with B. canis the UCr/SCr ratio was significantly lower and the RFI was significantly higher than in non-azotaemic dogs infected with B. canis. The calculated correlation between RFI and duration of the disease before diagnosis and treatment was high, positive and statistically significant (r = 0.89, p < 0.001). The results of this study showed that during the course of canine babesiosis caused by B. canis in Poland acute tubular necrosis may develop.
KeywordsAcute tubular necrosis azotaemia Babesia canis canine babesiosis renal failure index urinary creatinine to serum creatinine ratio
Unable to display preview. Download preview PDF.
- Cowgill L.D., Langston C. 2011. Acute kidney insufficiency. In: (Eds. Bartges J., Polzin D.J.) Nephrology and Urology of Small Animals. Wiley-Blackwell, Ames, 472–523.Google Scholar
- Hanson J., Hasan M.M.U., Royakkers A.A., Alam S., Charunwatthana P., Maude R.J., Douthwaite S.T., Yunus E.B., Mantha M.L., Schultz M.J., Faiz M.A., White N.J., Day N.P., Dondorp A.M. 2011. Laboratory prediction of the requirement for renal replacement in acute falciparum malaria. Malaria Journal, 10, 217. DOI: 10.1186/1475-2875-10-217.PubMedCrossRefGoogle Scholar
- Zygner W., Gójska-Zygner O., Długosz E., Wędrychowicz H. 2011. Liver enzyme activity in dogs infected with Babesia canis. Bulletin of the Veterinary Institute in Pulawy, 55, 423–427.Google Scholar
- Zygner W., Gójska-Zygner O., Wędrychowicz H. 2012. Changes in the SUSPPUP ratio and fractional excretion of strong monovalent electrolytes in hospitalized dogs with canine babesiosis caused by Babesia canis. Polish Journal of Veterinary Sciences, 15, 791–792. DOI: 10.2478/v10181-012-0119-y.PubMedCrossRefGoogle Scholar