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Assessment of Akodon cursor (Rodentia, Sigmodontinae) as permissive host to Schistosoma mansoni infection: morphology of adult worms

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Abstract

The natural infection with parasitic helminths is common in wild rodent populations. Once such interactions are better understood in the laboratory, it will be more feasible to extend the findings to infected hosts in nature. The flukes recovered from laboratory-infected Akodon cursor at 63 days post-infection were stained with hydrochloric carmine and individually mounted on glass slide as whole-mounts. Light and laser scanning confocal microscopy studies of adult male and female Schistosoma mansoni are reported. The parasites were examined morphologically and biometrically, which was obtained in a digital system for image analysis. Parameters used were: tegument thickness, digestive, excretory and reproductive systems. The overall conclusion of this experiment is that the morphological features of adult worm were similar to laboratory mice. It has been confirmed that the grass mouse is a permissive host to S. mansoni infection.

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References

  • Almeida C.R., Almeida A.M., Brasil D.P., Dantas Sobrinho J., Leal M.A. 1986. The rodent Akodon arviculoides Wagner, 1842 (Cricetidae) — importance in plague foci in Brazil. Memórias do Instituto Oswaldo Cruz, 81, 409–416. DOI: 10.1590/S0074-02761986000400008.

    Article  PubMed  Google Scholar 

  • Cheever A.W., Lenzi J.A., Lenzi H.L., Andrade Z.A. 2002. Experimental models of Schistosoma mansoni infection. Memórias do Instituto Oswaldo Cruz, 97, 917–940. DOI: 10.1590/S0074-02762002000700002.

    Article  PubMed  Google Scholar 

  • Cioli D., Knopf P.M., Senft A.W. 1977. A study of Schistosoma mansoni transferred into permissive and non-permissive hosts. International Journal for Parasitology, 7, 293–297. DOI:10.1016/0020-7519(77)90038-8.

    Article  PubMed  CAS  Google Scholar 

  • D’Andrea P.S., Horta C., Cerqueira R., Rey L. 1996. Breeding of the water rat (Nectomys squamipes) in the laboratory. Laboratory Animals, 30, 369–376. DOI: 10.1258/002367796780739835.

    Article  PubMed  Google Scholar 

  • D’Andrea P.S., Maroja L.S., Gentile R., Cerqueira R., Maldonado A., Rey L. 2000. The parasitism of Schistosoma mansoni (Digenea-Trematoda) in a naturally infected population of water rats, Nectomys squamipes (Rodentia: Cricetidae) in Brazil. Parasitology, 120, 573–582. DOI: 10.1017/S0031182099005892.

    Article  PubMed  Google Scholar 

  • D’Andrea P.S, Gentile R., Maroja L.S., Fernandes F.A., Coura R., Cerqueira R. 2007. Small mammal populations of an agroecosystem in the Atlantic forest domain, southeastern Brazil. Brazilian Journal of Biology, 67, 179–186. DOI: 10.1590/S1519-69842007000100025.

    Article  Google Scholar 

  • Freire N., Rodrigues-Silva R., Machado-Silva J.R., Rey L. 2003. A comparative parasitologic study on Biomphalaria glabrata snail and C3H/He mice infected with human and murine isolates of Schistosoma mansoni derived from Sumidouro, Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, 98, 783–787. DOI: 10.1590/S0074-02762003000600013.

    Article  PubMed  Google Scholar 

  • Gomes D.C., Vicente J.J. 1984. Helmintos parasitos de Nectomys squamipes (Brants) no município de Sumidouro, RJ. Memórias do Instituto Oswaldo Cruz, 79, 67–72. DOI: 10.1590/S0074-02761984000100008.

    Article  Google Scholar 

  • Gomes D.C., Lanfredi R.M., Pinto R.M., Souza W. 1992. Description of Trichuris travassosi nov. sp. (Nematoda: Trichurinae) from a brazilian rodent, by light and scanning electron microscopy. Memórias do Instituto Oswaldo Cruz, 87, 1–10. DOI: 10.1590/S0074-02761992000500004.

    Article  PubMed  Google Scholar 

  • Gomes D.C., Cruz R.P., Vicente J.J., Pinto R.M. 2003. Nematode parasites of marsupials and small rodents from the brazilian Atlantic forest in the state of Rio de Janeiro, Brazil. Revista Brasileira de Zoologia, 20, 699–707. DOI: 10.1590/S0101-81752003000400024.

    Article  Google Scholar 

  • Hulstijn M., Barros L.A., Neves R.H., Moura E.G., Gomes D.C., Machado-Silva J.R. 2006. Hermaphrodites and supernumerary testicular lobes in Schistosoma mansoni (Trematoda: Schistosomatidae) analyzed by brightfield and confocal microscopy. Journal of Parasitology, 92, 496–500. DOI: 10.1645/GE-3552.1.

    Article  PubMed  CAS  Google Scholar 

  • Lenzi J.A., Mota E.M., Pelajo-Machado M., Paiva R.A., Lenzi H.L. 1995. Calomys callosus: an alternative model to study fibrosis in schistosomiasis mansoni. The pathology of the acute phase. Memórias do Instituto Oswaldo Cruz, 90, 311–318. DOI: 10.1590/S0074-02761995000200034.

    Article  PubMed  CAS  Google Scholar 

  • Machado e Silva J.R., Oliveira R.M.F., Rodrigues-Silva R., Maldonado Jr. A., Rey L. 1991. Roedores silvestres como modelos experimentais da esquistossomose mansônica: Akodon arviculoides (Rodentia: Cricetidae). Revista do Instituto de Medicina Tropical de São Paulo, 33, 257–261. DOI: 10.1590/S0036-46651991000400003.

    Article  PubMed  Google Scholar 

  • Machado-Silva J.R., Galvão C., Presgrave O.A.F., Rey L., Gomes D.C. 1994. Host-induced morphological changes of Schistosoma mansoni Sambon, 1907 male worms. Memórias do Instituto Oswaldo Cruz, 89, 411–414. DOI: 10.1590/S0074-02761994000300021.

    Article  PubMed  CAS  Google Scholar 

  • Machado-Silva J.R., Galvão C., Oliveira R.M., Presgrave O.A., Gomes D.C. 1995. Schistosoma mansoni Sambon, 1907: comparative morphological studies of some brazilian strains. Revista do Instituto de Medicina Tropical de São Paulo, 37, 441–447. DOI: 10.1590/S0036-46651995000500010.

    Article  PubMed  CAS  Google Scholar 

  • Machado-Silva J.R., Lanfredi R.M., Gomes D.C. 1997. Morphological study of adult male worms of Schistosoma mansoni by scanning electron microscopy. Memórias do Instituto Oswaldo Cruz, 92, 647–653. DOI: 10.1590/S0074-02761997000500016.

    Article  PubMed  CAS  Google Scholar 

  • Machado-Silva J.R., Pelajo-Machado M., Lenzi H.L., Gomes D.C. 1998. Morphological study of adult male worms of Schistosoma mansoni Sambon, 1907 by confocal laser scanning microscopy. Memórias do Instituto Oswaldo Cruz, 93, 303–307. DOI: 10.1590/S0074-02761998000700060.

    Article  PubMed  Google Scholar 

  • Maldonado Jr. A., Machado-Silva J.R., Rodrigues-Silva R., Lenzi H.L., Rey L. 1994. Evaluation of the resistance to Schistosoma mansoni infection in Nectomys squamipes (Rodentia: Cricetidae) a natural host of infection in Brazil. Revista do Instituto de Medicina Tropical de São Paulo, 36, 193–198. DOI: 10.1590/S0036-46651994000300001.

    PubMed  Google Scholar 

  • Maldonado Jr. A., Gentile R., Fernandes-Moraes C.C., D’Andrea P.S., Lanfredi R.M., Rey L. 2006. Helminth communities of Nectomys squamipes naturally infected by the exotic trematode Schistosoma mansoni in southeastern Brazil. Journal of Helminthology, 80, 369–375. DOI: 10.1017/JOH2006366.

    Article  PubMed  Google Scholar 

  • Martinez E.M., Neves R.H., Oliveira R.M.F., Machado-Silva J.R., Rey L. 2003. Características biológicas e morfológicas de cepas brasileiras de Schistosoma mansoni em Mus musculus. Revista da Sociedade Brasileira de Medicina Tropical, 36, 557–564. DOI: 10.1590/S0037-86822003000500003.

    Article  PubMed  Google Scholar 

  • Mouhaid G., Casanova J.C., Moné H. 1997. Plasticidad fenotípica y determinacion sistemática de parásitos: el caso de Echinoparyphium elegans. Acta Parasitologica Portuguesa, 4, 127.

    Google Scholar 

  • Najim A.T. 1951. A male Schistosoma mansoni with two sets of testes. Journal of Parasitology, 37, 545–546. DOI: 10.2307/3273345.

    Article  PubMed  CAS  Google Scholar 

  • Neves R.H., Costa-Silva M., Martinez E.M., Branquinho T.B., Oliveira R.M.F., Lenzi H.L., Gomes D.C., Machado-Silva J.R. 2004. Phenotypic plasticity in adult worms of Schistosoma mansoni (Trematoda: Schistosomatidae) evidenced by brightfield and confocal laser scanning microscopies. Memórias do Instituto Oswaldo Cruz, 99, 131–136. DOI: 10.1590/S0074-02762004000200003.

    Article  PubMed  Google Scholar 

  • Neves R.H., Lamare C.B., Machado-Silva J.R., Carvalho J.J., Branquinho T.B., Lenzi H.L., Hulstijn M., Gomes D.C. 2005. A new description of the reproductive system of Schistosoma mansoni (Trematoda: Schistosomatidae) analyzed by confocal laser scanning microscopy. Parasitology Research, 95, 43–49. DOI: 10.1007/s00436-004-1241-2.

    Article  PubMed  Google Scholar 

  • Neves R.H., Pereira M.J.S., Gomes D.C., Oliveira R.M.F., Machado-Silva J.R. 1998. Morphometric differences of adult worms from sympatric samples of Schistosoma mansoni Sambon, 1907 isolated from rodents and humans. Memórias do Instituto Oswaldo Cruz, 93, 309–312. DOI: 10.1590/S0074-02761998000700061.

    Article  PubMed  Google Scholar 

  • Rey L. 1993. Non-human vertebrate hosts of Schistosoma mansoni and schistosomiasis transmission in Brazil. Research and Reviews in Parasitology, 53, 13–25.

    Google Scholar 

  • Ribeiro A.C., Maldonado Jr A., D’Andrea P.S., Vieira G.O., Rey L. 1998. Susceptibility of Nectomys rattus (Pelzen, 1883) to experimental infection with Schistosoma mansoni (Sambon, 1907): a potential reservoir in Brazil. Memórias do Instituto Oswaldo Cruz, 93, 295–299. DOI: 10.1590/S0074-02761998000700058.

    Article  PubMed  Google Scholar 

  • Rodrigues-Silva R., Machado-Silva J.R., Faerstein N.F, Rey L. 1992. Natural infection of wild rodents by Schistosoma mansoni. Parasitological aspects. Memórias do Instituto Oswaldo Cruz, 87, 271–276. DOI: 10.1590/S0074-02761992000500051.

    Article  Google Scholar 

  • Souza J., Digiani M.C., Simões R., Luque J.L., Rodrigues-Silva R., Maldonado Jr. A. 2008. A new Heligmonellidae (Nematoda) from Oligoryzomys nigripes (Rodentia: Sigmodontinae) in the atlantic forest, Brazil. Journal of Parasitology, 95, 734–738. DOI: 10.1645/GE-1836.1.

    Article  Google Scholar 

  • Souza V.A., Rodrigues-Silva R., Maldonado Jr. A., Machado-Silva J.R., Rey L. 1992. Nectomys squamipes (Rodentia: Cricetidae) as an experimental model for schistosomiasis mansoni. Memórias do Instituto Oswaldo Cruz, 87, 277–280. DOI: 10.1590/S0074-02761992000500052.

    Article  PubMed  Google Scholar 

  • Toledo R., Carpena I., Espert A., Sotillo J., Muñoz-Antoli C., Esteban J.G. 2006. A quantitative approach to the experimental transmission success of Echinostoma friedi (Trematoda: Echinostomatidae) in rats. Journal of Parasitology, 92, 16–20. DOI: 10.1645/GE-574R1.1.

    Article  PubMed  Google Scholar 

  • Valero A.M., Perez-Crespo I., Periago V.M., Khoubbane M., Mas-Coma S. 2009. Fluke egg characteristics for the diagnosis of human and animal fascioliasis by Fasciola hepatica and F. gigantica. Acta Tropica, 111, 150–159. DOI: 10.1016/j.actatropica.2009.04.005.

    Article  PubMed  Google Scholar 

  • Watson J.J., Pike A.W. 1993. Variation in the morphology of adult Apatemon gracilis Rudolphi, 1819 (Digenea: Strigeidae) reared in different avian hosts. Systematic Parasitology, 26, 33–38. DOI: 10.1007/BF00009645.

    Article  Google Scholar 

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Authors and Affiliations

  1. Laboratório Romero Lascasas Porto, Departamento de Microbiologia, Imunologia e Parasitologia, Faculdade de Ciências Médicas, UERJ, Av. Prof. Manoel de Abreu 444 - Vila Isabel, 20551-170, Rio de Janeiro, RJ, Brasil

    José Roberto Machado-Silva & Regina Maria Figueiredo de Oliveira

  2. Laboratório de Helmintos Parasitos de Vertebrados, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil

    Renata Heisler Neves & Rosângela Rodrigues-Silva

  3. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil

    Arnaldo Maldonado Júnior

Authors
  1. José Roberto Machado-Silva
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  2. Renata Heisler Neves
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  3. Rosângela Rodrigues-Silva
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  4. Regina Maria Figueiredo de Oliveira
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  5. Arnaldo Maldonado Júnior
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Correspondence to José Roberto Machado-Silva.

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CNPq research fellow

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Machado-Silva, J.R., Neves, R.H., Rodrigues-Silva, R. et al. Assessment of Akodon cursor (Rodentia, Sigmodontinae) as permissive host to Schistosoma mansoni infection: morphology of adult worms. Acta Parasit. 56, 147–153 (2011). https://doi.org/10.2478/s11686-011-0018-x

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  • DOI: https://doi.org/10.2478/s11686-011-0018-x

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