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Central European Journal of Medicine

, Volume 9, Issue 4, pp 550–555 | Cite as

Biological markers of severity in acute pancreatitis

  • Anna Pallisera
  • Rosa Jorba
  • Jose Manuel Ramia
  • Jose Antonio Rodriguez
  • Helena Subirana
  • Luis Ortiz de Zárate
  • Jose Antonio Gonzalez
  • Salvador Navarro
Research Article
  • 87 Downloads

Abstract

Abstract

None of the definitions of severity used in acute pancreatitis (AP) is ideal. Many of the scoring systems used to predict and measure its severity are complex, cumbersome and inaccurate.

Aim

to evaluate the usefulness of the most commonly used early markers for predicting severity, necrosis and mortality in patients with AP, and the need for surgery or Intensive Care Unit (ICU) admission.

Material&methods

Prospective study was performed from March 2009 to August 2010 based on patients diagnosed with AP seen consecutively at a secondary hospital. The early prognostic markers used were Apache II score ≥8 and Ranson’s score ≥3, RCP>120mg/l and Ht>44% in the first 24 hours.

Results

131 patients were prospectively enrolled. Median age was 63 years, 60% were men. The most frequent etiology of AP was biliary (68%). Fifteen patients were admitted to the ICU (11.6%) and five (3.9%) required surgery. Twelve patients (9.2%) had necrosis on CT. Four patients (3%) died, all of them in the Severe AP group. Only hematocrit>44 was predictor of mortality in univariate analysis.

Conclusion

hematocrit ≥ 44% was a significant predictor of mortality. The other indicators present limitations for predicting severity, necrosis and mortality, especially in the first 24 hours.

Keywords

Pancreatitis Organ failure Markers Surgery Review 

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Copyright information

© Versita Warsaw and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Anna Pallisera
    • 1
  • Rosa Jorba
    • 2
  • Jose Manuel Ramia
    • 3
  • Jose Antonio Rodriguez
    • 2
  • Helena Subirana
    • 2
  • Luis Ortiz de Zárate
    • 2
  • Jose Antonio Gonzalez
    • 4
  • Salvador Navarro
    • 1
  1. 1.Department of SurgeryHospital Parc Taulí SabadellSabadellSpain
  2. 2.Department of Surgery, Hospital General de l’HospitaletHospitalet de LlobregatBarcelonaSpain
  3. 3.Department of SurgeryHospital Universitario de GuadalajaraGuadalajaraSpain
  4. 4.Department of SurgeryHospital de la Santa Creu i Sant Pau BarcelonaBarcelonaSpain

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