Letter to the editor — inconsistency on frequencies of the human apolipoprotein E Gene expression
In this letter, we share our concerns regarding fluctuations of homozygosity for ApoE/ɛ4 allele. It appeared that over time, expression of this gene raised the felled as reported by various researchers. Considering the diversity of phenotypic characteristics assigned to expression of ApoE/ɛ4, seems to be a potentially useful to direct practitioner on concrete figures related to the genetic propensity of many conditions, from circulatory to mental disorders.
KeywordsAlzheimer’s disease ApoE/ɛ4 Chronic traumatic encephalopathy
- A.C. McKee, R.C. Cantu, C.J. Nowinski, E.T. Hedley-Whyte, B.E. Gavett, A.E. Budson, V.E. Santini, H.S. Lee, C.A. Kubilus, R.A. Stern. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol. 68 (2009) 709–735PubMedCentralPubMedCrossRefGoogle Scholar
- S. Yoshida, Y. Iwabuchi, Y Numachi, H. Saito, H. Yamazaki, H. Sakai, M. Kimura, H. Matsuoka, M Sato. Clinical features and alterations in the inferior horn sizes in lateral ventricle in Alzheimer’s patients with different ApoE genotype in Japanese population. Prog Neuropsychopharmacol Biol Psychiatry. 25 (2001) 1377–1384PubMedCrossRefGoogle Scholar