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Central European Journal of Medicine

, Volume 9, Issue 1, pp 40–44 | Cite as

Increased aortic stiffness in ulcerative colitis

  • Attila Nemes
  • Henriette Gavallér
  • Ferenc Nagy
  • József Náfrády
  • Tibor Wittmann
  • Tamás Forster
Research Article

Abstract

Introduction

Ulcerative colitis (UC) is a chronic inflammatory disease of the colon. Currently, there is an increased scientific interest in the evaluation of early functional vascular alterations, especially in inflammatory disorders. The present study was aimed to examine whether UC is associated with abnormalities in aortic elasticity.

Methods

The study was comprised of 11 UC patients (mean age 39 ± 12 years, 7 males), their results were compared to 22 age- and gender-matched controls. All subjects underwent a complete two-dimensional transthoracic Doppler echocardiography including evaluation of aortic elastic properties. The oscillometry-based Arteriograph device was used in all cases to measure aortic pulse-wave velocity (PWV) and augmentation index (Aix).

Results

Despite similar blood pressure values, aortic stiffness index, PWV and Aix were significantly increased, while pulsatile change in aortic diameter, aortic strain and aortic distensibility were significantly decreased in UC patients compared to controls.

Conclusion

Abnormal echocardiographic aortic elastic properties and Arteriograph-derived pulse-wave velocity could be demonstrated in patients with ulcerative colitis.

Keywords

Aortic Stiffness Distensibility Ulcerative colitis 

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References

  1. [1]
    Torres J, Billioud V, Sachar DB, et al. Ulcerative colitis as a progressive disease: The forgotten evidence. Inflamm Bowel Dis 2012; 18: 1356–1363PubMedCrossRefGoogle Scholar
  2. [2]
    Rellecke P, Strauer BE. Chronic inflammatory bowel disease and cardiovascular complications. Med Klin (Munich) 2006; 101Suppl 1): 56–60Google Scholar
  3. [3]
    McEniery CM, Wilkinson IB. Large artery stiffness and inflammation. J Hum Hypertens 2005; 19: 507–509PubMedCrossRefGoogle Scholar
  4. [4]
    Nemes A, Takács R, Gavallér H, et al. Correlations between Arteriograph-derived pulse wave velocity and aortic elastic properties by echocardiography. Clin Physiol Funct Imaging 2011; 31: 61–65PubMedCrossRefGoogle Scholar
  5. [5]
    Mowat C, Cole A, Windsor A, et al; IBD Section of the British Society of Gastroenterology. Guidelines for the management of inflammatory bowel disease in adults. Gut 2011; 60: 571–607PubMedCrossRefGoogle Scholar
  6. [6]
    ESH-ESC Guidelines Committee. Guidelines for the Management of Hypertension. 2003: 8–9Google Scholar
  7. [7]
    Stefanadis C, Stratos C, Boudoulas H, et al. Distensibility of the ascending aorta: comparison of invasive and non-invasive techniques in healthy men and in men with coronary artery disease. Eur Heart J 1990; 11: 990–996PubMedGoogle Scholar
  8. [8]
    Baulmann J, Schillings U, Rickert S, et al. A new oscillometric method for assessment of arterial stiffness: comparison with tonometric and piezoelectronic methods. J Hypertens 2008; 26: 523–528PubMedCrossRefGoogle Scholar
  9. [9]
    Horváth IG, Németh A, Lenkey Z, et al. Invasive validation of a new oscillometric device (Arteriograph) for measuring augmentation index, central blood pressure and aortic pulse wave velocity. J Hypertens 2010; 28: 2068–2075PubMedCrossRefGoogle Scholar
  10. [10]
    Gaszner B, Lenkey Z, Illyés M, et al. Comparison of aortic and carotid arterial stiffness parameters in patients with verified coronary artery disease. Clin Cardiol 2012; 35: 26–31PubMedCrossRefGoogle Scholar
  11. [11]
    Nemes A, Soliman OI, Geleijnse ML, et al. Increased aortic stiffness in glycogenosis type (Pompe’s disease). Int J Cardiol 2007; 120: 138–141PubMedCrossRefGoogle Scholar
  12. [12]
    Park S, Lakatta EG. Role of inflammation in the pathogenesis of arterial stiffness. Yonsei Med J 2012; 53: 258–261PubMedCentralPubMedCrossRefGoogle Scholar
  13. [13]
    Yildiz M. Arterial distensibility in chronic inflammatory rheumatic disorders. Open Cardiovasc Med J 2010; 4: 83–88PubMedCentralPubMedGoogle Scholar
  14. [14]
    Crilly MA, Kumar V, Clark HJ, et al. Arterial stiffness and cumulative inflammatory burden in rheumatoid arthritis: a dose-response relationship independent of established cardiovascular risk factors. Rheumatology (Oxford) 2009; 48: 1606–1612CrossRefGoogle Scholar
  15. [15]
    Akdogan RA, Durakoglugil ME, Kocaman SA, et al. Increased pulse wave velocity and carotid intimamedia thickness in patients with ulcerative colitis. Dig Dis Sci 2013; 58: 2293–2300PubMedCrossRefGoogle Scholar
  16. [16]
    Ito Y, Kume H, Goto K. Aortitis syndrome associated with ulcerative colitis, preceded by pulmonary infarction involvement. Nihon Kokyuki Gakkai Zasshi 2001; 39: 287–292PubMedGoogle Scholar
  17. [17]
    Hong JS, Jin SP, Choi M, et al.. Annular leukocytoclastic vasculitis in a patient with ulcerative colitis. Ann Dermatol 2011; 23 (Suppl 3): S338–S340CrossRefGoogle Scholar
  18. [18]
    Civan JM, Gilbert CR, Kastenberg DM. Pulmonary capillaritis: a rare extra-intestinal manifestation of inflammatory bowel disease. Am J Gastroenterol 2011; 106: 804–805PubMedCrossRefGoogle Scholar
  19. [19]
    Beccastrini E, Emmi G, Squatrito D, et al.. Lobular panniculitis with small vessel vasculitis associated with ulcerative colitis. Mod Rheumatol 2011; 21: 528–531PubMedGoogle Scholar
  20. [20]
    Sato R, Sato Y, Ishikawa H, et al. Takayasu’s disease associated with ulcerative colitis. Intern Med 1994; 33: 759–763PubMedCrossRefGoogle Scholar
  21. [21]
    Hokama A, Kinjo F, Arakaki T. Pulseless hematochezia: Takayasu’s arteritis associated with ulcerative colitis. Intern Med 2003; 42: 897–898PubMedCrossRefGoogle Scholar
  22. [22]
    Novacek G, Haumer M, Schima W, et al. Aortic mural thrombi in patients with inflammatory bowel disease: report of two cases and review of the literature. Inflamm Bowel Dis 2004; 10: 430–435PubMedCrossRefGoogle Scholar
  23. [23]
    Elder K, Hawi R, Al Solaiman F. Inflammatory bowel disease-related thoracic aortic thrombosis. South Med J 2010; 103: 172–174PubMedCrossRefGoogle Scholar
  24. [24]
    Sinapi I, Hammer F, Hainaut P. Aortic mural thrombi associated with ulcerative colitis. Acta Clin Belg 2010; 65: 54–55PubMedGoogle Scholar
  25. [25]
    Szychta P, Reix T, Sevestre MA, et al. Aortic thrombosis and ulcerative colitis. Ann Vasc Surg 2001; 15: 402–404PubMedCrossRefGoogle Scholar
  26. [26]
    Yela C, Manzano ML, Garfia C, et al.. Thrombosis of the superior temporal artery of the retina in a female patient with ulcerative colitis. Gastroenterol Hepatol 1996; 19: 281PubMedGoogle Scholar
  27. [27]
    Di Fabio F, Obrand D, Satin R, et al. Successful treatment of extensive splanchnic arterial and portal vein thrombosis associated with ulcerative colitis. Colorectal Dis 2009; 11: 653–655PubMedCrossRefGoogle Scholar
  28. [28]
    Elikowski W, Małek M, Lewandowska M, et al. Massive pulmonary embolism in a patient with ulcerative colitis and hyperhomocysteinaemia — a case report. Kardiol Pol 2006; 64: 405–409PubMedGoogle Scholar
  29. [29]
    Osato K, Takeda S, Takaki A, et al. Occurrence of disseminated intravascular coagulation (DIC) in an acute ulcerative colitis case. Rinsho Ketsueki. 1973; 14: 1182–1188PubMedGoogle Scholar
  30. [30]
    Karakurt C, Koçak G, Selimoğlu A, et al. Aortic aneurysm: a rare complication of ulcerative colitis. Anadolu Kardiyol Derg 2007; 7: 461–462PubMedGoogle Scholar

Copyright information

© Versita Warsaw and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Attila Nemes
    • 1
  • Henriette Gavallér
    • 1
  • Ferenc Nagy
    • 2
  • József Náfrády
    • 2
  • Tibor Wittmann
    • 2
  • Tamás Forster
    • 1
  1. 1.2nd Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical CentreUniversity of SzegedSzegedHungary
  2. 2.1st Department of Medicine, Medical Faculty, Albert Szent-Györgyi Clinical CentreUniversity of SzegedSzegedHungary

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