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Central European Journal of Medicine

, Volume 8, Issue 5, pp 571–576 | Cite as

Fracture risk prediction with FRAX in Slovak postmenopausal women

  • Eva Némethová
  • Zdenko Killinger
  • Juraj Payer
Research Article
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Abstract

Introduction

Current Slovak treatment thresholds in osteoporosis are based on bone mineral density (BMD) or a previous fracture. Some patients at high risk for fractures may not be identified. FRAX (Fracture Risk Assessment Tool) is based on patient risk profile assessment and calculates 10-year fracture risks. Using FRAX, treatment initiation could be more patient-specific.

Aim of study

To evaluate the risk profile with FRAX in slovak postmenopausal women, to identify those at high risk of fracture according to NOF (National Osteporosis Foundation) intervention thresholds based on FRAX and to compare this approach to current treatment thresholds.

Methods

We measured BMD at lumbar spine, femoral neck, total hip and calculated 10-year absolute fracture risks with the slovak version of FRAX in 365 patients.

Results

Average risk of major osteoporotic fracture was 10,39% and hip fracture 3,00%. 109 patients were eligible for treatment according to actual treatment criteria (88 based on BMD and 21 with previous fracture). In addition, 57 high risk osteopenic patients were identified by NOF thresholds using FRAX, who should be also considered for treatment.

Conclusion

Using FRAX and NOF thresholds it’s possible to identify high risk patients who don’t fulfill current treatment criteria but may profit from treatment.

Keywords

Osteoporosis Fracture risk FRAX Treatment thresholds 

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Copyright information

© Versita Warsaw and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Eva Némethová
    • 1
  • Zdenko Killinger
    • 1
  • Juraj Payer
    • 1
  1. 1.5th Department of Internal MedicineFaculty of Medicine Comenius University and University Hospital RužinovBratislavaSlovakia

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