Skip to main content

Advertisement

SpringerLink
Log in

Anti-granulocyte scintigraphy in early rheumatoid arthritis — does it work?

  • Research Article
  • Published:
Central European Journal of Medicine

Abstract

Objective

To compare the performance of anti-granulocyte scintigraphy with those of widely used prognostic indices (such as DAS28, anti-CCP, early MRI imaging).

Methods

Twenty-five patients with early arthritis were enrolled into the study. Following the review of clinical data and the evaluation of disease activity, we performed MRI imaging of the hands, anti-granulocyte scintigraphy, and determined anti-CCP positivity. The relationship between the changes of MRI scores and the above prognostic factors were analyzed statistically.

Results

At baseline, values were as follows: DAS28 3.86±1.19, CRI 0.15±0.12, MRI erosions and synovitis scores 25.11±12.82 and 4.32±4.02 (respectively), the ratio of anti-CCP positivity was 7/12 (58%). After the follow-up period of 13.6±2.52 months, erosion and synovitis scores were 43.11±22.23, and 5.32±6.16, respectively (p=0,001 and p=0,015). The occurrence of new erosions was correlated with baseline erosion score (k=0.523, p=0.022) and anti-CCP positivity (p=0.021). The relationship between CRI and baseline synovitis score was strong (=0.518, p=0.023), whereas it was weak only between the former and baseline erosion score (=0.402, p=0.08).

Conclusion

As shown by this study, potential markers for predicting subsequent destructiveness in early RA include MRI and anti-CCP testing, primarily. 99mTc labeled anti-granulocyte joint scintigraphy is appropriate for the objective and quantitative appraisal of disease activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Explore related subjects

Discover the latest articles, news and stories from top researchers in related subjects.

References

  1. Kellgren J.H., O’Brien W.M. On the natural history of rheumatoid arthritis in relation to the sheep cell agglutination test (SCAT), Arthritis. Rheum., 1962, 5, 115

    Google Scholar 

  2. Withrington R.H., Teitsson I., Valdimarsson H., Seifert M.H. Prospective study of early rheumatoid arthritis. II. Association of rheumatoid factor isotypes with fluctuations in disease activity, Ann. Rheum. Dis., 1984, 43(5), 679–685

    Article  PubMed  CAS  Google Scholar 

  3. Sharp J.T., Calkins E., Cohen A.S., Schubart A.F., Calabro J.J. Observations on the clinical, chemical, and serological manifestations of rheumatoid arthritis, based on the course of 154 cases, Medicine (Baltimore), 1964, 43, 41–58

    CAS  Google Scholar 

  4. Geborek P., Saxne T., Pettersson H., Wollheim F.A. Syno.vial fluid acidosis correlates with radiological joint destruction in rheumatoid arthritis knee joints, J. Rheumatol., 1989, 16(4), 468–472

    PubMed  CAS  Google Scholar 

  5. Tseng S., Reddi A.H., Di Cesare P.E. Cartilage Oligomeric Matrix Protein (COMP): A Biomarker of Arthritis, Biomark. Insights. 2009, 17(4), 33–44

    Google Scholar 

  6. Fujikawa K., Kawakami A., Tamai M., Uetani M., Takao S., Arima K., et al., High serum cartilage oligomeric matrix protein determines the subset of patients with early-stage rheumatoid arthritis with high serum C-reactive protein, matrix metalloproteinase-3, and MRI-proven bone erosion, J. Rheumatol., 2009, 36(6), 1126–1129

    Article  PubMed  CAS  Google Scholar 

  7. Syversen S.W., Goll G.L., van der Heijde D., Landewé R., Gaarder P.I., Odegård S., et al., Cartilage and bone biomarkers in rheumatoid arthritis: prediction of 10-year radiographic progression, J. Rheumatol. 2009, 36(2), 266–272

    Article  PubMed  CAS  Google Scholar 

  8. Rousseau J.C., Sumer E.U., Hein G., Sondergaard B.C., Madsen S.H., Pedersen C., et al., Patients with rheumatoid arthritis have an altered circulatory aggrecan profile, BMC Musculoskelet. Disord., 2008, 28,9:74

    Article  Google Scholar 

  9. Syversen S.W., Goll G.L., van der Heijde D., Landewé R., Lie B.A., Odegard, S., et al., Prediction of radiographic progression in rheumatoid arthritis and the role of antibodies against mutated citrullinated vimentin: results from a ten-year prospective study, Ann. Rheum. Dis., 2010. 69(2), 345–351

    Article  PubMed  CAS  Google Scholar 

  10. Firestein G.S., Etiology and pathogenesis of rheumatoid arthritis, In: Kelly’s Texbook of Rherumatology (Harris E.D.Jr, Budd R.C., Genovese M.C., Firestein G.S., Sargent J.S., Sledge B.C. eds) 7th ed. Oxford 2004, 996–1042

    Google Scholar 

  11. Gaál J., Mézes A., Síró B., Varga J., Galuska L., Jánoky G., et al., Tc99m HMPAO labeled leukocyte scintigraphy in patients with rheumatoid arthritis: a comparison with disease activity, Nucl. Med. Commun., 2002, 23:39–46

    Article  PubMed  Google Scholar 

  12. Arnett F.C., Edworthy S.M., Bloch D.A., McShane D.J., Fries J.F., Cooper N.S., et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis, Arthritis. Rheum., 1988, 31,:315–324

    Article  PubMed  CAS  Google Scholar 

  13. Klarlund M., Ostergaard M., Jensen K.E., Madsen J.L., Skjødt H., Lorenzen I., et al., Magnetic resonance imaging, radiography, and scintigraphy of the finger joints: one year follow up of patients with early arthritis. The TIRA Group, Ann. Rheum. Dis. 2000, 59(7), 521–528

    Article  CAS  Google Scholar 

  14. Fransen J., van Riel P.L., The Disease Activity Score and the EULAR response criteria, Rheum. Dis. Clin. North. Am., 2009, 35(4), 745–757

    Article  PubMed  Google Scholar 

  15. Hetland M.L., Ejbjerg B., Hørslev-Petersen K., Jacobsen S., Vestergaard A., Jurik A.G., et al. CIMESTRA study group., MRI bone oedema is the strongest predictor of subsequent radiographic progression in early rheumatoid arthritis. Results from a 2-year randomised controlled trial (CIMESTRA), Ann. Rheum. Dis., 2009, 68(3), 384–390

    Article  PubMed  CAS  Google Scholar 

  16. Palosaari K., Vuotila J., Takalo R., Jartti A., Niemelä R.K., Karjalainen A., et al. Bone oedema predicts erosive progression on wrist MRI in early RA-a 2-yr observational MRI and NC scintigraphy study, Rheumatology, 2006, 45(12), 1542–1548

    Article  PubMed  Google Scholar 

  17. Ostendorf B., Schneider M., [Imaging beyond conventional radiography: mini arthroscopy, duplex ultrasonography and positron emission tomography] Z. Rheumatol., 2003, 62(Suppl 2), II 37–40

    Google Scholar 

  18. van der Laken C.J., Elzinga E.H., Kropholler M.A., Molthoff C.F., van der Heijden J.W., Maruyama K., et al., Noninvasive imaging of macrophages in rheumatoid synovitis using 11C-(R)-PK11195 and positron emission tomography, Arthritis. Rheum., 2008, 58(11), 3350–3355

    Article  PubMed  Google Scholar 

  19. Möttönen T.T., Hannonen P., Toivanan J., Rekonen A., Oka M. M., Value of joint scintigraphy in the prediction of erosiveness in early rheumatoid arthritis, Ann. Rheum. Dis., 1988, 47, 183–189

    Article  PubMed  Google Scholar 

  20. de Bois M.H., Westedt M.L., Arndt J.W., Wiarda K.S., van der Velde E.A., Pauwels EK., et al., Value of 99mTc-IgG scintigraphy in the prediction of joint destruction in patients with rheumatoid arthritis of recent onset, Rheumatol. Int., 1995, 15(4), 155–158

    Article  PubMed  Google Scholar 

  21. Takalo R., Niemelä R., Karjalainen A., Leisti E.L., Kautiainen H., Hakala M., (99m)Technetium nanocolloid scintigraphy in prognostication of early RA Scand. J. Rheumatol. 2011, 40(2), 152–153

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, University of Debrecen, Medical & Health Sciences Centre, H-4032, Debrecen, Nagyerdei krt. 98., Hungary

    Edit Horkay

  2. Department of Rheumatology, ’Kenézy Gyula’ Hospital, H-4043, Debrecen, Bartók Béla u. 2-26., Hungary

    Gyöngyvér Kincse & János Gaál

  3. Department of Nuclear Medicine, University of Debrecen, Medical & Health Sciences Centre, H-4032, Debrecen, Nagyerdei krt. 98, Hungary

    József Varga

  4. Medical & Health Sciences Centre, PET-CT Medical Diagnostics Ltd., University of Debrecen, H-4032, Debrecen, Nagyerdei krt. 98, Hungary

    Lajos Szabados & Ildikó Garai

Authors
  1. Edit Horkay
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gyöngyvér Kincse
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. József Varga
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lajos Szabados
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ildikó Garai
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. János Gaál
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to János Gaál.

About this article

Cite this article

Horkay, E., Kincse, G., Varga, J. et al. Anti-granulocyte scintigraphy in early rheumatoid arthritis — does it work?. cent.eur.j.med 8, 558–564 (2013). https://doi.org/10.2478/s11536-013-0203-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2478/s11536-013-0203-4

Keywords

Search

Navigation