Differences on the prevalence of cervical HPV between Lithuania and Belarus
- 71 Downloads
In some countries the cervical cancer incidence and mortality rates are much higher compared to the European average. The differences of HPV and its type prevalence between countries and regions influence cervical cancer incidence and mortality. Regarding the differences in cervical cancer incidence and mortality in Lithuania and Belarus, the aim of this study was to describe HPV infection level and HPVs type distribution among two study groups of patients with moderate or severe cervical intraepithelial neoplasia (CIN2-3) and cervical cancer. Our data shows that 74.2% [95% CI: 63.64÷84.76] of Lithuanian patients with cervical cancer and 85.6% [95% CI: 85.53÷92.85] of the study group with CIN2-3 were HPV positive, while in the study groups of Belarusian patients HPV infection was detected in 92.6% [95% CI, 74.25÷98.71] and 65.4% [95% CI, 44.36÷82.06] cases respectively. HPV 16 was the most prevalent type in Lithuanian as well as in Belarusian patients of the study groups. HPV 18 in Lithuanian patients of the study group with cervical cancer was identified in 10.2% [95% CI: 1.73÷18.67] and in the study group with CIN2-3 — in 2.6% [95% CI: 0.95÷6.15] of cases. HPV 18 was not detected in Belarusian patients of both groups.
KeywordsHPV infection Cervical intraepithelial neoplasia Cervical cancer
Unable to display preview. Download preview PDF.
- Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. Lyon, France: International Agency for Research on Cancer, 2010. Available from: http://globocan.iarc.fr, accessed on day/month/yearGoogle Scholar
- WHO/Europe, European HFA Database, January 2012Google Scholar
- Popendikyte V, Gulbinovic I, Paulauskiene V, Paulauskas D. High risk human papilloma virus detection and genotyping by multiplex PCR. Lietuvos akuserija ir ginekologija (Lithuanian Obstetrics and Gynecology) 2000;11:348–352Google Scholar
- Gudlevicienė Z, Didziapetriene J, Suziedelis K, Lapkauskaite L. Investigation of human papillomavisur its types and variants. Medicina (Lithuania) 2005;41(11):910–915Google Scholar
- Wężowska M, Giedrys-Kalemba S, Szymaniak L, Borowiec-Chłopek Ż, Konstanty-Kurkiewicz V, Menkiszak J. Risk factors for cervical cancer among young women. Central European Journal of Medicine. Central European Journal of Medicine 2012, DOI: 10.2478/s11536-012-0063-3Google Scholar
- IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Vol. 90, Human Papillomaviruses, IARC Monographs 2007Google Scholar