Central European Journal of Medicine

, Volume 8, Issue 4, pp 392–397 | Cite as

Therapy with acetylsalicylic acid does not interfere with oral surgery

  • Damian M. Dudek
  • Krzysztof J. Helewski
  • Grzegorz Wyrobiec
  • Marzena J. Harabin-Słowińska
  • Grażyna I. Kowalczyk-Ziomek
  • Małgorzata M. Żaba
  • Piotr Wesołowski
  • Tomasz Stawski
  • Romuald J. Wojnicz
Research Article

Abstract

The acetylsalicylic acid (ASA) treatment is widespread therapeutic strategy in cardiology clinics. On the other hand, patients with heart diseases represent a significant group of cases in dental clinics. Accordingly, we studied the local hemostatic thrombus formation after dental tooth extractions (n=47) and other oral surgery treatment (n=13) in 60 patients with heart disease being on ASA therapy without drug discontinuation. In the control group free of ASA therapy it was: (n=24) and (n=6), respectively. In all studied patients, the aggregative activity of blood platelets by PFA-100 analyzer was assessed. It was found that 61.7% patients treated with ASA presented inhibition of platelets aggregation. Unexpectedly, in 35% of such patients, platelet aggregation function remained unchanged. In the control group, normal platelet aggregation was found in all subjects. It has been shown that ASA therapy has neutral effects on both thrombus formation and pain complications in patients with heart disease underwent tooth extraction and other oral surgery. Thus discontinuation of ASA therapy before surgery seems to be weakly validated.

Keywords

Platelets Acetylsalicylic acid Oral surgery Dental tooth extraction 

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Copyright information

© Versita Warsaw and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Damian M. Dudek
    • 1
    • 2
  • Krzysztof J. Helewski
    • 2
  • Grzegorz Wyrobiec
    • 2
  • Marzena J. Harabin-Słowińska
    • 2
  • Grażyna I. Kowalczyk-Ziomek
    • 2
  • Małgorzata M. Żaba
    • 2
  • Piotr Wesołowski
    • 3
  • Tomasz Stawski
    • 4
  • Romuald J. Wojnicz
    • 2
  1. 1.Private Department of Oral Surgery and ImplantologyToruńPoland
  2. 2.Department of Histology and EmbryologyMedical University of Silesia in KatowiceZabrzePoland
  3. 3.Department of Dental SurgeryMedical University of WarsawWarszawaPoland
  4. 4.Department of SurgeryMunicipal HospitalJaworznoPoland

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