An education-behavioural intervention improves adherence to statins
- 109 Downloads
Effective treatment of hyperlipidemia is an important precondition for cardiovascular diseases. Unfortunately, adherence to lipid-lowering treatment is unsatisfactory. In order to improve adherence to statins, an intervention combining educational and behavioural components was tested in general practice settings.
A total of 198 outpatients with untreated hyperlipidemia were enrolled in this open-label, prospective, randomised study. Patients were prescribed simvastatin, in initial dosage of 20 mg daily, and followed for 48 weeks. Intervention group received educational counseling at each visit (that is every 8 weeks); and were also asked to adopt a routine evening activity of their choice for a reminder. Control group obtained usual care. Primary outcome measure was patient adherence, expressed as medication possession ratio (MPR).
Patients’ mean age was 59.6 +/- 9.1 years. Study arms differed in their level of adherence: mean ± SD MPR was 95.4±53.7% and 81.7±31.0%, for intervention and control group, respectively (P<0.05). Patients from intervention group found a reminder activity useful in over 90% of cases.
Simple inexpensive educational-behavioural intervention proved to be effective in enhancing adherence to statins in hyperlipidemia. Given the health and economic consequences of non-adherence, these results may have high clinical, and practical usefulness.
KeywordsPatient adherence Statins Hyperlipidemia Education-behavioural intervention Primary prevention Secondary prevention
Unable to display preview. Download preview PDF.
- Sabate E (red). Adherence to long-term therapies: evidence for action. Geneva, World Health Organization, 2003Google Scholar
- Kardas P. Prevalence and reasons for non-adherence to hyperlipidemia treatment. Submitted to Centr Eur J Med, 2013Google Scholar
- Kardas P, Lewek P, Matyjaszczyk M. Determinants of patient adherence: a review of systematic reviews. Submitted to Front Pharmacol. 2013Google Scholar
- Konduracka E, Jozwiak J, Mastej M et al. Rozpowszechnienie i niska skutecznosc leczenia dyslipidemii w prewencji pierwotnej i wtornej choroby niedokrwiennej serca na poziomie lekarzy medycyny rodzinnej — wyniki ogolnopolskiego badania epidemiologicznego LIPIDOGRAM 2004. Przegl Lek 2008;65(12): 834–837PubMedGoogle Scholar
- Grzelak-Hodor J. Brak compliance w leczeniu statynami. Puls Medycyny 19(202), 2009Google Scholar
- Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2008; (2): CD000011Google Scholar
- Nieuwkerk PT, Nierman MC, Vissers MN, Locadia M, Greggers-Peusch P, Knape LP, Kastelein JJ, Sprangers MA, de Haes HC, Stroes ES. Intervention to Improve Adherence to Lipid-Lowering Medication and Lipid-Levels in Patients With an Increased Cardiovascular Risk. Am J Cardiol. 2012 Sep 1;110(5):666–672CrossRefGoogle Scholar