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CEACAM5 is correlated with Angio/Lymphangiogenesis of Prostatic Lesions

  • Research Article
  • Published:
Central European Journal of Medicine

Abstract

Objective

The aim of this study was to examine the expression patterns of CEACAM5 in prostatic non-neoplastic and neoplastic lesions and further investigate its relationship with tumor microvessel density(MVD) and lymphatic vessel density(LVD).

Methods

CEACAM5 expression was detected using immunohistochemical staining in a serial sections of the benign prostatic hyperplasia (BPH), prostate intraepithelial neoplasia (PIN) and prostate carcinoma (PCa) lesions. MVD and LVD were quantified in CEACAM5 positive areas by dual-labelling with CD34 and D2-40 respectively.

Results

Both PIN and PCa had significantly higher expression for CEACAM5 than BPH which has no positive expression for CEACAM5(P<0.05). In PIN and PCa, CEACAM5 staining showed different expression patterns in terms the of most of membranous staining for PIN, less membranous staining and more cytoplasmic staining for PCa. MVD results showed that PCa and PIN had more angiogenesis than BPH tissue. The value of MVD in PCa tissue was correlated with tumor Gleason grading (P<0.05). LVD results showed that neoplastic lesions had more lymphangiogenesis than non-neoplastic lesion.

Conclusion

CEACAM5 had different expression patterns in prostatic non-neoplastic and neoplastic lesions, and these various expression patterns may be correlated with tumor progression through promoting tumorous angiogenesis or lymphangiogenesis.

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Authors and Affiliations

  1. Department of Renal transplantation, The Second Hospital, Shandong University, 247#, BeiYuan Street, Jinan, Shandong, 250033, P. R. China

    Jie-ke Yan, Chuan Tian, Shuang-de Liu, Xiao-li Liu, Dong-sheng Xu, Rong-mei Zhang, Hong-wei Wang & Shengtian Zhao

  2. Clinical Department, Jinan Nursing Vocational College, 3636#, GangXi Road, Jinan, Shandong, 250102, P. R. China

    Yu-zhen Wang

  3. Department of Pathology, The Second Hospital, Shandong University, 247#, BeiYuan Street, Jinan, Shandong, 250033, P. R. China

    Cheng-jun Zhou

  4. Department of Blood Component, Blood Center of Shandong Province, Jinan, Shandong, 250014, P. R. China

    Wei-dong He

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  1. Jie-ke Yan
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  2. Yu-zhen Wang
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  3. Chuan Tian
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  4. Shuang-de Liu
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  10. Hong-wei Wang
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  11. Shengtian Zhao
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Correspondence to Shengtian Zhao.

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Yan, Jk., Wang, Yz., Tian, C. et al. CEACAM5 is correlated with Angio/Lymphangiogenesis of Prostatic Lesions. cent.eur.j.med 9, 264–271 (2014). https://doi.org/10.2478/s11536-013-0153-x

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  • DOI: https://doi.org/10.2478/s11536-013-0153-x

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