Effects of Rhodiola rosea extract on passive avoidance tests in rats
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The purpose was to evaluate the effects of extract of Rhodiola rosea on learning and memory processes on rats. The two series of experiments were carried out — on naïve rats and on rats with scopolamine-impaired memory. The passive avoidance tests were performed — step-down and step-through. The latency of reactions in seconds was observed in both tests. Naïve rats treated with the extract in showed the prolongation of latency of reaction of both step-down and step-through passive avoidances compared to the controls. Rats with scopolamine-impaired memory showed shorter latency of reaction in both passive avoidance tests compared to the controls. Rats treated with the extract of Rh. Rosea with scopolamine-impaired memory prolonged the latency in both passive avoidance tests compared to scopolamine group. It was found that the extract of Rh. Rosea improved performance during learning session, short and long memory retrieval tests in naïve rats. Scopolamine impaired the learning and memory retrieval of rats, but Rh. Rosea pretreatment improved performance and turned off the deterioration effect of scopolamine on these brain functions probably by non-specific mechanisms on cholinergic neurons. The studied plant extract can be a candidate for treatment of dementia and other memory disturbances.
KeywordsExtract of Rhodiola rosea Learning and memory processes Passive avoindance tests Step-down Step-through Scopolamine-impaired memory
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- Qu ZQ., Zhou Y., Zeng YS., Li Y., Cheng Pl., Pretreatment with Rhodiola rosea extract reduces cognitive impairment induced by intracerebrovascular streptozotocin in rats: implication of anti-oxidative and neuroprotective effects, Biomedical and Enviromental Science, 2009, 22, 318–326CrossRefGoogle Scholar
- Elamen A., Dragland S., Klemsdal SS., Bioactive compounds produced by clones of Rhodiola rosea maintained in the Norwegian germplasm collection, Pharmazie, 2010, 65, 618–23Google Scholar
- Evstatieva L., Todorova M., Antonova D., Quality control of extracts of Rhodiola rosea L. based on the content of salidroside and rosavines, Proc, 5 CMAPSEEC, 2011, 208, 2–5Google Scholar
- Tulsawani B., Meena DK., Shukla H., Sharma P., Meena RV., Gupta V., et al., Ninety days of repeated gavage administration of Rhodiola extract in rats, J Appl Toxicology, 2011, 10, 1009–1015Google Scholar
- Petkov VD., Yonkov D., Mosharoff A., Kambourova T., Alova L., Petkov VV., et al, Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory, Acta Physiol Pharmacol Bulg, 1986, 12, 3–16Google Scholar
- Wiedenfield H., Dumaa M., Malinowski M., Furmanowa M., Naratuya S., Phytochemical and analytical studies of extracts from Rhodiola rosea and Rhodiola quadrifolia, Pharmazie, 2007, 64, 308–11.Google Scholar
- Edwards D., Heufelder A., Zimmermann A., Therapeutic effects and safety of Rhodiola rosea extract WS 1375 in subjects with life-stress symptoms-results of an open-label study, Phythother Res, 2012, doi:10.1002/ptr.3712.Google Scholar