Advertisement

Central European Journal of Medicine

, Volume 8, Issue 2, pp 208–212 | Cite as

Prevalence of Legionella antibodies in immunocompromised patients

  • Agnieszka Sikora
  • Maria Kozioł-Montewka
  • Andrzej Książek
  • Agnieszka Grzebalska
  • Anna Bednarek-Skublewska
  • Anna Steć
  • Sławomir Rudzki
  • Jacek Furmaga
  • Jolanta Paluch-Oleś
  • Agnieszka Magryś
  • Magdalena Karaś
Research Article
  • 119 Downloads

Abstract

Introduction

Dialysis patients and patients post-renal transplantation can be predisposed to Legionella infections. The aim of this work was to investigate the prevalence of L. pneumophila serogroups 1–7 (SG 1–7) antibodies in dialysis patients and in patients following renal transplantation, in order to analyse the potential risk factors for infections.

Material and Methods

Commercial ELISA kits were used for detection of serum IgG (SG 1–7, SG 1) and IgM (SG 1–7) present in patients and the control group. Results: In the studied group of patients, positive results (IgM and/or IgG SG 1–7) were obtained in 20 patients (7.12%). One patient only had two classes of antibodies. From the total study group, the antibodies against L. pneumophila SG 1 were detected in only one patient on dialysis. Patients with L. pneumophila antibodies who are on dialysis or post-renal transplantation did not differ significantly in any of the usually evaluated risk factors of clinical infection.

Conclusions

The reported outbreaks of Legionnaires’ disease in chronic dialysis patients and those with renal transplants, as well as our results of IgG and IgM antibodies, merit further identification of the sources of this infection but also the ways in which cellular immune system can be managed in the immunocompromised patients with Legionella infection.

Keywords

Legionella pneumophila antibodies Risk factors Dialysis patients Patients post-renal transplantation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    Nichol K.L., Parenti C.M., Jonhson J.E. High prevalence of positive antibodies to Legionella pneumophila among outpatients, Chest, 1991, 100(3):663–666PubMedCrossRefGoogle Scholar
  2. [2]
    Friedman H., Yamamoto Y., Klein T.W. Legionella pneumophila pathogenesis and immunity, Semin. Pediatr. Infect. Dis., 2002, 13(4):273–279PubMedCrossRefGoogle Scholar
  3. [3]
    Diederen B.M.W. Legionella spp. and legionnaires’disease, J Infect, 2008, 56(1):1–12PubMedCrossRefGoogle Scholar
  4. [4]
    Javed S., Chaudhry R., Passi K., Sharma S., Dhawan B., Dey A.B. Sero diagnosis of Legionella infection in community acquired pneumonia, Indian J. Med. Res., 2010, 131:92–96PubMedGoogle Scholar
  5. [5]
    Fields B.S., Benson F., Besser R.E. Legionella nad legionnaires’disease: 25 years of investigation, Clin. Microbiol. Rev., 2002, 15(3):506–526PubMedCrossRefGoogle Scholar
  6. [6]
    Shimizu Y., Nagase K., Kadono K.N., Funayama Y., Tsurushima Y., Hibino T., et al. The haemodialysis patient who developed acute respiratory distress syndrome after a trip to a hot spring spa, Nephrol. Dial. Transplant., 1999, 14(2):455–457PubMedCrossRefGoogle Scholar
  7. [7]
    Ongut G., Yavuz A., Ogunc D., Tuncer M., Ozturk F., Mutlu D., et al. Seroprevalence of antibodies to Legionella pneumophila on hemodialysis patients, Transplant. Proc., 2004, 36(1):44–46PubMedCrossRefGoogle Scholar
  8. [8]
    Matuszewska R., Krogulska B. Problem występowania pałeczek Legionella w instalacjach i urządzeniach wytwarzających aerozol wodnopowietrzny w obiektach służby zdrowia w Polsce, Nowa Med., 2009, 1:56–60Google Scholar
  9. [9]
    Friedman H., Yamamoto Y., Newton C., Klein T. Immunologic response and pathophysiology of Legionella infection, Semin. Respir. Infect., 1998, 13(2):100–108PubMedGoogle Scholar
  10. [10]
    Lettinga K.D., Verbon A., Weverling J.G., Schellekens FP, Den Boer J.W., Yzerman P.F., et al. Legionnaires’disease at a dutch flower show: prognostic factors and impact of therapy, Emerg. Infect. Dis., 2002, 8(12):1448–1454PubMedCrossRefGoogle Scholar
  11. [11]
    Ampel N.M., Wing E.J. Legionella infection in transplant patients, Semin. Respir. Infect., 1990, 5(1):30–37PubMedGoogle Scholar
  12. [12]
    Berman S.J. Infections in patients with end-stage renal disease: an overview, Infect. Dis. Clin. North. Am., 2001, 15(3):709–720PubMedCrossRefGoogle Scholar
  13. [13]
    Chow J.W. Legionella: a major opportunictic pathogen in transplant recipients. Semin. Respir. Infect., 1998, 13(2):132–139.PubMedGoogle Scholar
  14. [14]
    Foley R.N. Infections in patients with chronic kidney disease, Infect. Dis. Clin. North. Am., 2007, 21(3):659–672PubMedCrossRefGoogle Scholar
  15. [15]
    Girndt M., Sester M., Sester U., Kaul H., Kohler H. Molecular aspects of T- and B-cell function in uremia, Kidney Int. Suppl., 2001, 78:S206–211PubMedGoogle Scholar
  16. [16]
    Minnaganti V.R., Cunha BA. Infections associated with uremia and dialysis, Infect. Dis. Clin. North. Am., 2001, 15(2):385–306PubMedCrossRefGoogle Scholar
  17. [17]
    Boldur I., Modai D., Iaine A., Boner G., Sompolinsky D. Legionnaires’disease in Israel: a serological study of hemodialysis patients, Isr. J. Med. Sci., 1982, 18(6):667–670PubMedGoogle Scholar
  18. [18]
    Pesanti E.L. Immunologic defects and vaccination in patients with renal failure, Infect. Dis. Clin. North. Am. 2001, 15(3):813–832PubMedCrossRefGoogle Scholar
  19. [19]
    Kool J.L., Fiore A.E., Kioski C.M., Brown E.W., Benson R.F., Pruckler J.M., et al. More than 10 years of unrecognized nosocomial transmission of legionnaires’disease among transplant patients, Infect. Control Hosp. Epidemiol., 1998, 19(12):898–904PubMedCrossRefGoogle Scholar
  20. [20]
    Marshall W., Foster R.S., Winn W. Legionnaires’disease in renal transplant patients, Am. J. Surg., 1981, 141(4):423–429PubMedCrossRefGoogle Scholar
  21. [21]
    Mazierii N.A., Godoy C.V., Alves S.F., Andrade D.R., Levin A.S., Hablitzel A.C. Legionnaires’disease in the renal transplant unit of “Hospital das Clinicas, FMUSP”, During a five year period (1988–1993), Rev. Inst. Med. Trop. Sao Paulo 1994, 36(3):231–236CrossRefGoogle Scholar
  22. [22]
    Morimoto T. Serum antibodies to Legionella pneumohila by indirect immunofluorescent antibody test in 269 hemodialysis patients and 353 healthy subjects, Rinsho Byori., 1991, 39(1):71–75PubMedGoogle Scholar

Copyright information

© Versita Warsaw and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Agnieszka Sikora
    • 1
  • Maria Kozioł-Montewka
    • 1
  • Andrzej Książek
    • 2
  • Agnieszka Grzebalska
    • 2
  • Anna Bednarek-Skublewska
    • 2
  • Anna Steć
    • 2
  • Sławomir Rudzki
    • 3
  • Jacek Furmaga
    • 3
  • Jolanta Paluch-Oleś
    • 1
  • Agnieszka Magryś
    • 1
  • Magdalena Karaś
    • 4
  1. 1.Department of Medical MicrobiologyMedical University of LublinLublinPoland
  2. 2.Department of NephrologyMedical University of LublinLublinPoland
  3. 3.I Chair and Department of General and Transplant Surgery and Nutritional TreatmentMedical University of LublinLublinPoland
  4. 4.Department of Genetics and MicrobiologyMaria Curie-Skłodowska UniversityLublinPoland

Personalised recommendations