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Urine saturation and promoter/inhibitor parameters and ratios in renal stone disease caused by ceftriaxone

Central European Journal of Medicine volume 8, pages 354–357 (2013)Cite this article

Abstract

During ceftriaxone treatment of subdural empyema caused by Streptococcus intermedius urinary and biliary stones were noticed. Increased levels of urinary calcium excretion were detected during ongoing treatment in comparison with 2 months check-up. There were no significant changes in the promoter/inhibitor urolithiasis parameters, oxalate, citrate, urate, cistine, glycosaminoglycans or their ratios. Urine saturation was calculated using EQUIL 2 computer programme (calcium oxalate, brushite) and it was normal. Probable trigger for the ceftriaxone/calcium hydroxy carbonate phosphate mixture of stones was a critical boost of solubility products caused by ceftriaxone treatment and phospnate urine content with a subsequent large-scale spontaneous precipitation of crystals.

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Authors and Affiliations

  1. Department for Pediatric Nephrology, University Children’s Hospital Zagreb, Zagreb School of Medicine, Kišpatićeva 12, 10000, Zagreb, Croatia

    Danko Milošević, Danica Batinić, Anja Tea Golubić & Daniel Turudić

  2. Department for Pediatric Infectious diseases, School of Medicine, Zagreb University, Zagreb, Croatia

    Branko Miše

  3. Department for Physical chemistry, Institute „Ruđer Bošković“, Bijenička cesta 54, 10000, Zagreb, Croatia

    Ivan Habuš

  4. Department of Anesthesiology and Intesive Care, University Clinical Centre Zagreb, Zagreb, Croatia

    Marija Topalović-Grković

Authors
  1. Danko Milošević
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  2. Branko Miše
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  3. Ivan Habuš
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  4. Marija Topalović-Grković
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  5. Danica Batinić
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  6. Anja Tea Golubić
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  7. Daniel Turudić
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Correspondence to Danko Milošević.

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Milošević, D., Miše, B., Habuš, I. et al. Urine saturation and promoter/inhibitor parameters and ratios in renal stone disease caused by ceftriaxone. cent.eur.j.med 8, 354–357 (2013). https://doi.org/10.2478/s11536-012-0091-z

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  • DOI: https://doi.org/10.2478/s11536-012-0091-z

Keywords

  • Ceftriaxone
  • Urolythiasis
  • Urine saturation
  • Stone promoters/inhibitors