Central European Journal of Medicine

, Volume 8, Issue 3, pp 354–357 | Cite as

Urine saturation and promoter/inhibitor parameters and ratios in renal stone disease caused by ceftriaxone

  • Danko Milošević
  • Branko Miše
  • Ivan Habuš
  • Marija Topalović-Grković
  • Danica Batinić
  • Anja Tea Golubić
  • Daniel Turudić
Case Report


During ceftriaxone treatment of subdural empyema caused by Streptococcus intermedius urinary and biliary stones were noticed. Increased levels of urinary calcium excretion were detected during ongoing treatment in comparison with 2 months check-up. There were no significant changes in the promoter/inhibitor urolithiasis parameters, oxalate, citrate, urate, cistine, glycosaminoglycans or their ratios. Urine saturation was calculated using EQUIL 2 computer programme (calcium oxalate, brushite) and it was normal. Probable trigger for the ceftriaxone/calcium hydroxy carbonate phosphate mixture of stones was a critical boost of solubility products caused by ceftriaxone treatment and phospnate urine content with a subsequent large-scale spontaneous precipitation of crystals.


Ceftriaxone Urolythiasis Urine saturation Stone promoters/inhibitors 


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Copyright information

© Versita Warsaw and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Danko Milošević
    • 1
  • Branko Miše
    • 2
  • Ivan Habuš
    • 3
  • Marija Topalović-Grković
    • 4
  • Danica Batinić
    • 1
  • Anja Tea Golubić
    • 1
  • Daniel Turudić
    • 1
  1. 1.Department for Pediatric NephrologyUniversity Children’s Hospital Zagreb, Zagreb School of MedicineZagrebCroatia
  2. 2.Department for Pediatric Infectious diseases, School of MedicineZagreb UniversityZagrebCroatia
  3. 3.Department for Physical chemistryInstitute „Ruđer Bošković“ZagrebCroatia
  4. 4.Department of Anesthesiology and Intesive CareUniversity Clinical Centre ZagrebZagrebCroatia

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