Detection of presensitization in recipients of kidney transplants
- 44 Downloads
The preformed antibodies detection in potential kidney recipients is necessary in pretransplant evaluation. The aim of this study was to determine the correlation between the application of blood transfusions and sensitization level in potential kidney transplants.
The study included 268 potential kidney transplants from the region of Vojvodina. The presence of preformed antibodies was tested by microlymphocitotoxicity test. Pearson’s correlation coefficient was applied to determine the influence of three variables on sensitization level: number and volume of transfused blood units and time elapsed from last transfused unit.
Of 268 eligible patients, 206 patients had a history of blood transfusion. Results of the study showed that the application of great number and volume of transfused units increased the sensitization level (correlation coefficients were r = +0,283 and r = +0,235, respectively) with statistical significance as well as the negative correlation between the time elapsed from the last transfusion and the degree of sensitization (r = −0,082) with no statistical significance.
Our study revealed that there is a stronger positive correlation between the number of received blood units than the volume of received blood products and the level of preformed antibodies.
KeywordsAnti-HLA antibodies Preformed antibodies Kidney transplantation Sensitization
Unable to display preview. Download preview PDF.
- Cecka JM., The OPTN/UNOS renal transplant registry, Clin. Transplant., 2005, 1–16Google Scholar
- Cecka JM., The OPTN/UNOS Renal Transplant Registry, Clin. Transplant., 2004, 1–16Google Scholar
- Amico P., Evolution of graft survival in kidney transplantation: an analysis of the OPTN/UNOS Renal Transplant Registry, Clin. Transplant., 2010, 1–15Google Scholar
- Persijn GG., Allocation of organs, particularly kidneys, within Eurotransplant, Hum. Immunol., 2006, 67, 419–423Google Scholar
- Hardy S., Lee SH., Terasaki PI., Sensitization 2001, Clin. Transplant., 2001, 271Google Scholar
- Eikmans M., Waanders MM., Roelen DL., van Miert PP., Anholts JD., de Fijter HW., et al., Differential effect of pretransplant blood transfusions on immune effector and regulatory compartments in HLA-sensitized and nonsensitized recipients, Transplantation., 2010, 90, 1192–1199PubMedCrossRefGoogle Scholar
- Petz B., Osnovne statističke metode, Zagreb: Izdanja škole narodnog zdravlja “Andrija Štampar”, 1964, 111–133Google Scholar
- Katznelson S., Bhaduri S., Cecka JM., Clinical aspects of sensitization, Clin. Transplant., 1997, 285–296Google Scholar