Microvascular angina in diabetic patients with uninjured coronary arteries
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The study aims at the evaluation, of patients with chest pain and uninjured coronary arteries, and the impact of diabetes mellitus on coronary microcirculation. Moreover we want to verify whether a correlation between myocardial scintigraphy results and coronary angiography or not.
The study population included 316 patients (173 males,143 females) with uninjured coronary arteries. Patients with chest pain (208) were divided into two populations: diabetics (72) and non-diabetics (136).We compared 66 patients with a myocardial scintigraphy with results of angiographic indexes. On angiographic images we evaluated, on the three major epicardial, Gibson’s indexes (TFC, MBG), the Yusuf’s index(TMBS) and a new index: Total Timi Frame Count (TTFC).
Patients with positive scintigraphy had a worse TMBS than patients with negative scintigraphy (p=0.003) and a lower TFC of healthy vessels than diseased vessels (p=0.0001). We found a worse coronary microcirculation in diabetic patients with lower values of MBG and TMBS (p=0.02),compared with non- diabetics. New index TTFC is usually higher in diabetics than non-diabetic patients.
The study of microcirculation by coronary angiography and myocardial scintigraphy shows a good correlation between two methods. The analysis of diabetic patients and non-diabetic with chest pain and uninjured coronary arteries has led to assess that diabetic population has a major microcirculation disease.
KeywordsChest pain Coronary angiography Diabetes mellitus Microcirculation Myocardial scintigraphy
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- Rosano G, Lindsey D, Kaski JC et al. Syndrome X in women: The importance of ovarian hormones. J Am CollCardiol 1992; 19: 225AGoogle Scholar
- Milio G., Novo G, Novo S et al. Changes of arterial hemodynamics in patients with type 2 diabetes mellitus or impaired glucose tolerance. IntAngiol. 2006 Mar;25(1):73–77.Google Scholar