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The role of selected risk factors for development of oesophageal cancer

  • Research Article
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Central European Journal of Medicine

Abstract

A hospital-based analytical observational case-control study of 88 oesophageal cancer cases and 200 controls was conducted in the University Hospital Olomouc. A standardized questionnaire was used. The adjusted odds ratio (OR) are calculated by logistic regression. The adjusted odds ratios for tobacco smoking were 6.20 (95% CI 2.78–13.83), 10.64 (95% CI 3.46–32.72) and 3.53 (95% CI 1.26–9.88) for oesophageal cancer, for oesophageal squamous cell carcinoma, and oesophageal adenocarcinoma, respectively. An inverse association with overweight and obesity was found in both histological types. In adenocarcinoma, there was a relatively strong positive association with a statistically significant result for alcohol consumption only in a group consuming more than 300 g of alcohol weekly; the OR was 5.81 (95% CI 1.17–28.84). The strong, statistically significant association was found in alcohol consumption regardless of histological type: the OR was 4.41 (95% CI 1.09–17.84). In a group with 20 or more X-ray exposures, there was a very strong statistically significant positive association. In vegetable consumption, an inverse association was found that was statistically significant only if more than 8 portions of vegetables were eaten weekly, ORs were 0.02–0.11.

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Authors and Affiliations

  1. Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hněvotínská 3, Olomouc, 775 15, Czech Republic

    Helena Kollárová, Kateřina Azeem, Silvie Magnusková, Jarmila Ševčíková, Dagmar Horáková & Vladimír Janout

  2. Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Syllabova 19, Ostrava, 703 00, Czech Republic

    Hana Tomášková

  3. Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Ostrava, Syllabova 19, Ostrava, 703 00, Czech Republic

    Vojtěch Kamarád

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  1. Helena Kollárová
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  2. Kateřina Azeem
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  3. Silvie Magnusková
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  4. Hana Tomášková
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Correspondence to Kateřina Azeem.

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Kollárová, H., Azeem, K., Magnusková, S. et al. The role of selected risk factors for development of oesophageal cancer. cent.eur.j.med 8, 30–40 (2013). https://doi.org/10.2478/s11536-012-0054-4

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