Central European Journal of Medicine

, Volume 8, Issue 1, pp 30–40 | Cite as

The role of selected risk factors for development of oesophageal cancer

  • Helena Kollárová
  • Kateřina AzeemEmail author
  • Silvie Magnusková
  • Hana Tomášková
  • Jarmila Ševčíková
  • Dagmar Horáková
  • Vojtěch Kamarád
  • Vladimír Janout
Research Article


A hospital-based analytical observational case-control study of 88 oesophageal cancer cases and 200 controls was conducted in the University Hospital Olomouc. A standardized questionnaire was used. The adjusted odds ratio (OR) are calculated by logistic regression. The adjusted odds ratios for tobacco smoking were 6.20 (95% CI 2.78–13.83), 10.64 (95% CI 3.46–32.72) and 3.53 (95% CI 1.26–9.88) for oesophageal cancer, for oesophageal squamous cell carcinoma, and oesophageal adenocarcinoma, respectively. An inverse association with overweight and obesity was found in both histological types. In adenocarcinoma, there was a relatively strong positive association with a statistically significant result for alcohol consumption only in a group consuming more than 300 g of alcohol weekly; the OR was 5.81 (95% CI 1.17–28.84). The strong, statistically significant association was found in alcohol consumption regardless of histological type: the OR was 4.41 (95% CI 1.09–17.84). In a group with 20 or more X-ray exposures, there was a very strong statistically significant positive association. In vegetable consumption, an inverse association was found that was statistically significant only if more than 8 portions of vegetables were eaten weekly, ORs were 0.02–0.11.


Oesophageal adenocarcinoma Oesophageal squamous cell carcinoma Risk factor Protective factor Case-control study Analysis 


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Copyright information

© Versita Warsaw and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Helena Kollárová
    • 1
  • Kateřina Azeem
    • 1
    Email author
  • Silvie Magnusková
    • 1
  • Hana Tomášková
    • 2
  • Jarmila Ševčíková
    • 1
  • Dagmar Horáková
    • 1
  • Vojtěch Kamarád
    • 3
  • Vladimír Janout
    • 1
  1. 1.Department of Preventive Medicine, Faculty of Medicine and DentistryPalacky University OlomoucOlomoucCzech Republic
  2. 2.Department of Epidemiology and Public Health, Faculty of MedicineUniversity of OstravaOstravaCzech Republic
  3. 3.Department of Anatomy, Histology and Embryology, Faculty of MedicineUniversity of OstravaOstravaCzech Republic

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