Evidences for oxidative stress in essential hypertension
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This study explores the degree of oxidative stress in essential arterial hypertension (EAH). Even oxidative stress appears as one of several metabolic abnormalities involved in essential hypertension, it remains uncertain whether is primary or secondary. However measurement of the main oxidant may be useful in order to recognize and monitor oxidative stress.
Lipid peroxidation products (TBA reac tive substances) were determined in red blood cells (RBC) and serum together with markers of antioxidant status: total antioxidative capacity (AOC), catalase activity (CAT) and RBC glutathione (GSH) content in four investigated groups. The first group consisted of regularly and adequately treated hyper tensive patients without complication (regulated), patients with hyper tension and complication of some organs and organic systems were the non-regulated group. Third group were patients at the beginning of EAH (non-treated) and controls were normotensive individuals.
Compared with controls, regulated and non-treated group, non-regulated hyper tensive pati ents had higher TBARS concen tration in plasma (p<0.001) and lower AOC, CAT activity without differences in GSH content.
Recent findings suggest that hyper tension is a condition followed by intensive oxidative stress and reduced antioxidant factors. Adequate and strictly controlled therapy, hygienic and diet regime and possible use of antioxidants can signi fi cantly reduce blood pressure and prevent possible complications.
KeywordsBlood pressure Hypertension Oxidative stress
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- Keaney JF, Larson MG, Vasan RS, Wilson WF, Lipinska I, Corey D, Massaro MJ, Sutherland P, Vita JA, Benjamin EJ (2003) Obesity and systemic oxidative stres. Clinical corelates of oxidative stress in the Framingham study. Hypertension 23(3): 432–449Google Scholar
- Koraćević D, Koraćević G, ĐorĐević V, Andrejević S (1997) Simple method for the estimation of antioxidant activity in serum and other biological fluids. Balk J Clin Lab 3–4: 23–28Google Scholar
- Koroljuk AM, Ivanova IL, Majorova GI, Tokarev IB (1988) Metod opredeljenja aktivnosti katalazi. Lab Delo 1: 16–18Google Scholar
- Ménard J, Chatellier G (1995) Limiting factors in the control of BP: why is there a gap between theory and practice? J Hum Hypertens 2: 19–23Google Scholar
- Tamer L, Sucu N, Polat G, Ercan B, Aytacoglu B, Yücebilgiç G, Unlü A, Dikmengil M, Atik U (2002) De creased serum total antioxidant status and erythrocyte-reduced glutathione levels are associated with increased serum malondialdehyde in atherosclerotic patients. Arch Med Res 33(3): 257–260PubMedCrossRefGoogle Scholar
- D’souza A, Kurien BT, Rodgers R, Shenoi J, Kurono S, Matsumoto H, Hensley K, Nath SK, Scofield HR (2008) Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE. BMC Medical Genetics 9: 62PubMedCrossRefGoogle Scholar
- Zhou XF, Cui J, DeStefano AL, Chazaro I, Farrer LA, Manolis AJ, Gavras H, Baldwin CT (2005) Polymorphisms in the promoter region of catalase gene and essential hypertension. Dis Mar kers 21(1): 3–7Google Scholar