Central European Journal of Medicine

, Volume 7, Issue 2, pp 258–261 | Cite as

Neutrophil to lymphocyte count ratio as a biomarker of bacterial infections

  • Michal Holub
  • Ondřej Beran
  • Nikola Kaspříková
  • Pavel Chalupa
Research Article


The implementation of new markers of bacterial infection into clinical practice is hindered by their costs. We assessed the potential use of the neutrophil to lymphocyte count ratio (NLCR) to discriminate between bacterial and viral infections. NLCR was evaluated in 45 patients with bacterial infections: 24 patients with viral infections and 18 healthy adults. The medians of NLCR were 11.73 in bacterial infections, 2.86 in viral infections and 1.86 in controls. The NLCR cut-off value of 6.2 exhibited a sensitivity value of 0.91 and a specificity value of 0.96 for bacterial infection. These results suggest a diagnostic potential for NLCR.


Bacterial infection Viral infection Laboratory diagnosis Marker Neutrophil to lymphocyte ratio 


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Copyright information

© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Michal Holub
    • 1
  • Ondřej Beran
    • 1
  • Nikola Kaspříková
    • 2
  • Pavel Chalupa
    • 1
  1. 1.Department of Infectious and Tropical Diseases, First Faculty of MedicineCharles University in Prague and University Hospital BulovkaPragueCzech Republic
  2. 2.Institute of Biophysics and Informatics, First Faculty of MedicineCharles University in PraguePragueCzech Republic

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