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Coffee consumption and risk of stroke: a meta-analysis of cohort studies

Central European Journal of Medicine volume 7, pages 310–316 (2012)Cite this article

Abstract

Aims

Several studies have been done to investigate the correlation between coffee consumption and risk of stroke. The results are inconsistent. This meta-analysis is to evaluate the pooled effect of coffee consumption on risk of stroke.

Methods

We searched PubMed and Embase for all cohort studies on stroke and coffee consumption in humans with original data. Data from 13 studies involving 12414 stroke cases among 492760 individuals were pooled. The outcome considered was the occurrence of any type of stroke. Fixed effect model was used for the analysis of pooled relative risk. Heterogeneity was tested. If any existed, randomized effect model was used.

Results

Comparing with non coffee drinking, all coffee consumption could reduce total stroke by 11% (95%CI: 0.81, 0.97). In women, coffee consumption could reduce stroke risk by 17% (95%CI: 0.79, 0.87). Although there is no statistical difference in men, coffee consumption showed the tendency of decreasing stroke risk. Light, moderate and heavy coffee consumption could reduce the all type stroke risk by 10% (95%CI: 0.85, 0.96), 14% (95%CI: 0.76, 0.97), and 17% (95%CI: 0.78, 0.89) respectively.

Conclusions

This meta-analysis is strongly supportive of the hypothesis that coffee consumption at different level, reduces the risk of stroke.

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Authors and Affiliations

  1. Department of Neurology, The first affiliated hospital of Zhengzhou University, No.1 Jianshe East Road, 450000, Zhengzhou, China

    Rui Zhang, Bo Song & Yuming Xu

  2. The MR Research Centre, Aarhus University Hospital, No.100 Brendstrupgaardsvej, DK - 8200, Aarhus N, Denmark

    Rui Zhang & Hans Stødkilde Jørgensen

  3. Department of Urology, The first affiliated hospital of Zhengzhou University, No.1 Jianshe East Road, 450000, Zhengzhou, China

    Yan Wang

Authors
  1. Rui Zhang
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  2. Yan Wang
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  3. Bo Song
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  4. Hans Stødkilde Jørgensen
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  5. Yuming Xu
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Corresponding author

Correspondence to Yuming Xu.

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Zhang, R., Wang, Y., Song, B. et al. Coffee consumption and risk of stroke: a meta-analysis of cohort studies. cent.eur.j.med 7, 310–316 (2012). https://doi.org/10.2478/s11536-011-0154-6

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  • DOI: https://doi.org/10.2478/s11536-011-0154-6

Keywords

  • Stroke
  • Risk
  • Coffee
  • Caffeine
  • Meta analysis
  • Cohort studies