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The relationships between depression and life activities and well-being of multiple sclerosis patients

  • Research Article
  • Published:
Central European Journal of Medicine

Abstract

Multiple sclerosis (MS) is one of the most disabling neurodegenerative disorders. Depression is the most frequent psychiatric disorder accompanying MS. Although much attention is given to correlations between depression and MS clinical factors, analysis of correlations between depression and life activities (social, household, professional activities and family life) and the well-being of MS patients’ is insufficient. However, improvement of these functions could positively influence the outcomes of MS treatment. The aim of this study was to evaluate relationships between depression, life activities of MS patients, and their proposals how to improve the well-being. Materials and methods. The study lasted three years with 270 adult MS patients involved in it. ICD-10 criteria were used to diagnose depression. Original questionnaire was used to measure life activities and the well-being of the patients. Results. Prevalence of depression was 20.7% with no difference regarding the gender. Almost 84% of depressed respondents indicated, that MS disturbs their family life, 71.4% recommended to assign more attention to MS in general and 64.3% — to include more medications into reimbursement list. Conclusions. MS patients diagnosed with depression significantly more often than non-depressed indicate that MS disturbs their family life; recommend to assign more attention to MS in general and to include more medications into reimbursement list.

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References

  1. Pugliatti M., Sotgiu S., Rosati G., The worldwide prevalence of multiple sclerosis, Clin. Neurol. Neurosurg., 2002, 104(3), 182–191

    Article  PubMed  Google Scholar 

  2. Pugliatti M., Rosati G., Carton H., Riise T., Drulovic J., Vecsei L., et al., The epidemiology of multiple sclerosis in Europe, Eur. J. Neurol., 2006, 13(7), 700–722

    Article  PubMed  CAS  Google Scholar 

  3. Frohman E.M., Racke M.K., Raine C.S., Multiple sclerosis — the plaque and its pathogenesis, N. Engl. J. Med., 2006, 354(9), 942–955

    Article  PubMed  CAS  Google Scholar 

  4. Bar-Or A., Immunology of multiple sclerosis, Neurol. Clin., 2005, 23, 149–175

    Article  PubMed  Google Scholar 

  5. Janardhan V., Bakshi R., Quality of life in patients with multiple sclerosis: the impact of fatigue and depression, J. Neurol. Sci.., 2002, 205(1), 51–58

    Article  PubMed  Google Scholar 

  6. Giannini M.J., Bergmark B., Kreshover S., Elias E., Plummer C., O’Keefe E., Understanding suicide and disability through three major disabling conditions: Intellectual disability, spinal cord injury, and multiple sclerosis, Disabil. Health J., 2010, 3(2), 74–78

    Article  PubMed  Google Scholar 

  7. Fragoso Y.D., Frota E.R., Lopes J.S., Noal J.S., Giacomo M.C., Gomes S., et al., Severe depression, suicide attempts, and ideation during the use of interferon beta by patients with multiple sclerosis, Clin. Neuropharmacol., 2010, 33(6), 312–316

    Article  PubMed  CAS  Google Scholar 

  8. Patten S.B., Beck C.A., Williams J.V., Barbui C., Metz L.M., Major depression in multiple sclerosis: a population-based perspective, Neurology, 2003, 61(11), 1524–1527

    PubMed  CAS  Google Scholar 

  9. Siegert R.J., Abernethy D.A., Depression in multiple sclerosis: a review, J. Neurol. Neurosurg. Psychiatry, 2005, 76(4), 469–475

    Article  PubMed  CAS  Google Scholar 

  10. Chwastiak L., Ehde D.M., Gibbons L.E., Sullivan M., Bowen J.D., Kraft G.H., Depressive symptoms and severity of illness in multiple sclerosis: epidemiological study of a large community sample, Am. J. Psychiatry, 2002, 159(11), 1862–1868

    Article  PubMed  Google Scholar 

  11. Wynia K., Middel B., van Dijk J.P., De Keyser J.H., Reijneveld S.A., The impact of disabilities on quality of life in people with multiple sclerosis, Mult. Scler., 2008, 14, 972–980

    Article  PubMed  CAS  Google Scholar 

  12. Putzki N., Fischer J., Gottwald K., Reifschneider G., Ries S., Siever A., et al., Quality of life in 1000 patients with early relapsing-remitting multiple sclerosis, Eur. J. Neurol., 2009, 16, 713–720

    Article  PubMed  CAS  Google Scholar 

  13. Hermann B.P., Vickrey B., Hays R.D., Cramer J., Devinsky O., Meador K., et al., A comparison of health-related quality of life in patients with epilepsy, diabetes, and multiple sclerosis, Epilepsy Res. 1996, 25(2), 113–118

    Article  PubMed  CAS  Google Scholar 

  14. Hart S., Fonareva I., Merluzzi N., Mohr D.C., Treatment for depression and its relationship to improvement in quality of life and psychological well-being in multiple sclerosis patients, Quality of Life Res., 2005, 14(3), 695–703

    Article  Google Scholar 

  15. Sobocki P., Pugliatti M., Lauer K., Kobelt G., Estimation of the cost of MS in Europe: extrapolations from a multinational cost study, Mult. Scler., 2007, 13(8), 1054–1064

    Article  PubMed  CAS  Google Scholar 

  16. Riazi A., Hobart J., Lamping D., Fitzpatrick R., Freeman J., Jenkinson C., at al., Using the SF-36 measure to compare the health impact of multiple sclerosis and Parkinson’s disease with normal population health profiles, J. Neurol. Neurosurg. Psychiatry, 2003, June, 74(6), 710–714

    Article  PubMed  CAS  Google Scholar 

  17. Kurtzke J.F., Rating neurological impairment in multiple sclerosis: an expanded disability status scale (EDSS), Neurology, 1983, 33(11), 1444–1452

    PubMed  CAS  Google Scholar 

  18. Moran P.J., Mohr D.C., The validity of Beck Depression Inventory and Hamilton Rating Scale for Depression items in the assessment of depression among patients with multiple sclerosis, J. Behav. Med., 2005, 28(1), 35–41

    Article  PubMed  Google Scholar 

  19. Zung W.W.K., A self-rating depression scale, Arch. Gen. Psychiatry, 1965, 12, 63–70

    PubMed  CAS  Google Scholar 

  20. Friedman S., Even C., Samuelian J.C., Guelfi J.D., Factor structure of the Hospital Anxiety and Depression (HAD) Scale, B. J. Psychiatry, 2002, 181(8), 165–166

    CAS  Google Scholar 

  21. The ICD-10 Classification of Mental and Behavioural Disorders, Diagnostic criteria for research, World Health Organization, Geneva, 1993

    Google Scholar 

  22. Arnett P.A., Randolph J.J., Longitudinal course of depression symptoms in multiple sclerosis, J. Neurol. Neurosurg. Psychiatry, 2006, 77(5), 606–610

    Article  PubMed  CAS  Google Scholar 

  23. Galeazzi G.M., Ferrari S., Giaroli G., Mackinnon A., Merelli E., Motti L., et al., Psychiatric disorders and depression in multiple sclerosis outpatients: impact of disability and interferon beta therapy, Neurol. Sci., 2005, 26(4), 255–262

    Article  PubMed  CAS  Google Scholar 

  24. McGuigan C., Hutchinson M., Unrecognized symptoms of depression in a community-based population with multiple sclerosis, J. Neurol., 2006, 253(2), 219–232

    Article  PubMed  CAS  Google Scholar 

  25. Kessler R.C., Berglund P., Demler O., Jin R., Koretz D., Merikangas K.R., et al., The epidemiology of major depressive disorder. Results from the National Comorbidity Survey Replication (NCS-R), JAMA, 2003, 289(23), 3095–3105

    Article  PubMed  Google Scholar 

  26. Rihmer Z., Angst J., Mood disorders: epidemiology, In: Kaplan & Sadock’s Comprehensive Textbook of Psychiatry, 8th ed. (1), Lippincott Williams & Wilkins, Philadelphia, 2005, 1575–1582

    Google Scholar 

  27. Piccinelli M., Wilkinson G., Gender differences in depression. Critical review, Br. J. Psychiatry, 2000, 177, 486–492

    Article  PubMed  CAS  Google Scholar 

  28. Buchanan R.J., Wang S., Tai-Seale M., Ju H., Analyses of nursing home residents with multiple sclerosis and depression using the Minimum Data Set, Mult. Scler., 2003, March, 9(2), 171–188

    Article  PubMed  Google Scholar 

  29. Chwastiak L.A., Ehde D.M., Psychiatric Issues in Multiple Sclerosis, Psychiatr. Clin. North. Am., 2007, 30(4), 803–817

    Article  PubMed  Google Scholar 

  30. Sollom A.C., Kneebone I.I., Treatment of depression in people who have multiple sclerosis. Mult. Scler., 2007, Jun, 13(5), 632–635

    Article  PubMed  CAS  Google Scholar 

  31. Blazer D.G., Depression in late life: review and commentary, J. Geront.: Med. Sci., 2003, 58A(3), 249–265

    Article  Google Scholar 

  32. Tandberg E., Larsen J.P., Aarsland D., Cummings J.L, The occurrence of depression in Parkinson’s disease. A community-based study, Arch. Neurol., 1996, 53(2), 175–179

    PubMed  CAS  Google Scholar 

  33. Reijnders J. S., Ehrt U., Weber W. E., Aarsland D. and Leentjens A. F., A systematic review of prevalence studies of depression in Parkinson’s disease. Mov. Disord., 2008, 23(2), 183–189

    Article  PubMed  Google Scholar 

  34. Massie M.J., Prevalence of depression in patients with cancer, J. Natl. Cancer Inst. Monogr., 2004, 32, 57–71

    Article  PubMed  Google Scholar 

  35. Ciaramella A., Poli P., Assessment of depression among cancer patients: the role of pain, cancer type and treatment, Psychooncology, 2001, 10(2), 156–165

    Article  PubMed  CAS  Google Scholar 

  36. Anderson R.J., Freedland K.E., Clouse R.E., Lustman P.J., The prevalence of comorbid depression in adults with diabetes. A meta-analysis, Diabetes Care, 2001, 24(6), 1069–1078

    Article  PubMed  CAS  Google Scholar 

  37. Goldney R.D., Phillips P.J., Fisher L.J., Wilson D.H., Diabetes, depression, and quality of life: a population study, Diabetes Care, 2004, 27(5), 1066–1070

    Article  PubMed  Google Scholar 

  38. Thombs B.D., Bass E.B., Ford D.E., Stewart K.J., Tsilidis K.K., Patel U., et al., Prevalence of depression in survivors of acute myocardial infarction, J. Gen. Int. Med., 2006, 21, 30–38

    Article  Google Scholar 

  39. Beal C., Stuifbergen A.K., Sands D.V., Brown A., Depression in multiple sclerosis: a longitudinal analysis, Arch. Psychiatr. Nurs., 2007, 21, 181–191

    Article  PubMed  Google Scholar 

  40. Minden S.L., Mood disorders in multiple sclerosis: diagnosis and treatment, J. Neurovirol., 2000, 6(2), 160–167

    Google Scholar 

  41. Pfleger C.C., Flachs E.M., Koch-Henriksen N., Social consequences of multiple sclerosis (1): early pension and temporary unemployment—a historical prospective cohort study, Mult. Scler., 2010, Jan, 16(1), 121–126

    Article  PubMed  Google Scholar 

  42. Pfleger C.C., Flachs E.M., Koch-Henriksen N., Social consequences of multiple sclerosis: clinical and demographic predictors — a historical prospective cohort study, Eur. J. Neurol., 2010, 17(11), 1346–1351

    PubMed  CAS  Google Scholar 

  43. Julian L.J., Vella L., Vollmer T., Hadjimichael O., Mohr D.C., Employment in multiple sclerosis. Exiting and re-entering the work force, J. Neurol., 2008, 255(9), 1354–1360

    Article  PubMed  Google Scholar 

  44. Busche K.D., Fisk J.D., Murray T.J., Metz L.M., Short term predictors of unemployment in multiple sclerosis patients. Can. J. Neurol. Sci., 2003, 30(2), 137–142

    PubMed  CAS  Google Scholar 

  45. Putzki M., Fischer J., Gottwald K., Reifschneider G., Ries S., Siever A. et al., Quality of life in 1000 patients with early relapsing-remitting multiple sclerosis, Eur. J. Neurol., 2009, 16(6), 713–720

    Article  PubMed  CAS  Google Scholar 

  46. Jongen P.J., Sindic C., Carton H., Zwanikken C., Lemmens W., Borm G., Improvement of health-related quality of life in relapsing remitting multiple sclerosis patients after 2 years of treatment with intramuscular interferon beta — 1a. J. Neurol., 2010, Apr, 257(4), 584–589

    Article  PubMed  CAS  Google Scholar 

  47. Einarsson U., Gottberg K., Fredrikson S., von Koch L., Holmqvist L.W., Activities of daily living and social activities in people with multiple sclerosis in Stockholm County, Clin. Rehabil., 2006, 20(6), 543–551

    Article  PubMed  CAS  Google Scholar 

  48. Buhse M., Assessment of caregiver burden in families of persons with multiple sclerosis, J. Neurosci. Nurs., 2008, 40(1), 25–31

    Article  PubMed  Google Scholar 

  49. Pfleger C.C., Flachs E.M., Koch-Henriksen N., Social consequences of multiple sclerosis. Part 2. Divorce and separation: a historical prospective cohort study, Mult. Scler., 2010, 16(7), 878–882

    Article  PubMed  CAS  Google Scholar 

  50. MacLurg K., Reilly P., Hawkins S., Grav O., Evason E., Whittington D., A primary care-based needs assessment of people with multiple sclerosis, Br. J. Gen. Pract., 2005, 55(514), 378–383

    PubMed  CAS  Google Scholar 

  51. Vazirinejad R., Lilley J., Ward C., A health profile of adults with multiple sclerosis living in the community, Mult. Scler., 2008, 14(8), 1099–1105

    Article  PubMed  CAS  Google Scholar 

  52. Koopman W.J., Benbow C.L., Vandervoort M., Top 10 needs of people with multiple sclerosis and their significant others. J. Neurosci. Nurs., 2006, 38(5), 369–373

    Article  PubMed  Google Scholar 

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Correspondence to Rytis Leonavičius.

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Leonavičius, R., Adomaitienė, V. & Leskauskas, D. The relationships between depression and life activities and well-being of multiple sclerosis patients. cent.eur.j.med 6, 652–661 (2011). https://doi.org/10.2478/s11536-011-0059-4

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  • DOI: https://doi.org/10.2478/s11536-011-0059-4

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