Trimester dependent preterm births in pregnancy with genital herpes

  • Ferenc Bánhidy
  • István Dudás
  • Andrew E. Czeizel
Research Article


Previous studies reported controversial results regarding the possible association of recurrent genital herpes during pregnancy with a higher risk of preterm birth/low birth weight in newborns. Thus, birth outcomes of mothers with prospective and medically recorded symptomatic recurrent genital herpes confirmed by serological examination and of mothers without genital herpes were compared in the population-based large data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities. Our results showed that of 38,151 newborn infants, 86 (0.23%) had mothers with symptomatic recurrent genital herpes confirmed by serological examination during pregnancy. The rate of preterm births (14.0% vs. 9.2%) was higher in babies born to mothers with symptomatic recurrent genital herpes (OR with 95% CI: 1.7, 1.0–3.1) and this increase showed a trimester dependence with the highest rate in the third trimester (23.5%; OR with 95% CI: 2.6, 1.5–4.5). In conclusion, clinically diagnosed recurrent genital herpes during the third trimester of pregnancy associated with high risk for preterm birth.


Recurrent genital herpes Gestational age at delivery Preterm birth 


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Copyright information

© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Ferenc Bánhidy
    • 1
  • István Dudás
    • 2
  • Andrew E. Czeizel
    • 2
  1. 1.Second Department of Obstetrics and GynecologySemmelweis University, School of MedicineBudapestHungary
  2. 2.Foundation for the Community Control of Hereditary DiseasesBudapestHungary

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