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Prevalence of nephrolithiasis in polycystic kidney disease

  • Alma Idrizi
  • Myftar Barbullushi
  • Margarita Gjata
  • Alketa Koroshi
  • Enver Roshi
  • Teuta Backa
  • Sulejman Kodra
  • Nestor Thereska
Research Article

Abstract

We aim to define the prevalence of nephrolithiasis, the impact of anatomic and metabolic factors to stone formation and prognosis of patients with autosomal dominant polycystic kidney disease in Albania. We included 200 patients with autosomal dominant polycystic kidney from 2002 to 2009. The patients underwent X-ray, renal ultrasonography. We performed the metabolic evaluation of blood and urine. Survival times were calculated as the time to dialysis, transplantation, or death. Kaplan-Meier product-limit survival curves were constructed. Log rank test was used to compare the survival curves. Nephrolithiasis was present in 116 of our patients with autosomal dominant polycystic kidney disease (58%), with a mean age 46.4±5.7 years. Sixty five patients with kidney stones (56%) were women. The stones were composed primarily of urate (47%) and calcium oxalate (39%), and other compounds 14%. In 40% of patients the presence of stones was associated with a history of urinary tract infections and flank pain. In our study the prevalence of nephrolithiasis is 58%, higher than it reported in literature. Except anatomic and metabolic factors, there are other contributor factors to stone formation in our patients such socioeconomic status of patients, geographic zones and dietary habits.

Keywords

Autosomal dominant polycystic kidney disease Gross hematuria Metabolic factors Nephrolithiasis Urinary tract infections 

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Copyright information

© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Alma Idrizi
    • 1
  • Myftar Barbullushi
    • 1
  • Margarita Gjata
    • 2
  • Alketa Koroshi
    • 1
  • Enver Roshi
    • 3
  • Teuta Backa
    • 4
  • Sulejman Kodra
    • 1
  • Nestor Thereska
    • 1
  1. 1.Service of NephrologyUHC “Mother Teresa”TiranaAlbania
  2. 2.Service of Internal MedicineUHC “Mother Teresa”TiranaAlbania
  3. 3.Department of Public HealthUHC “Mother Teresa”TiranaAlbania
  4. 4.Department of Internal MedicineUHC “Mother Teresa”TiranaAlbania

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