Central European Journal of Medicine

, Volume 6, Issue 4, pp 475–479 | Cite as

Diabetes insipidus due to pituitary metastasis in a woman with lung adenocarcinoma: a case report

  • Chen-Hao Hsiao
  • Chung-Yih Wang
  • Ming-Teng Chung
  • Ming-Sung Yang
Case Report


Metastatic tumors of the pituitary are uncommon and usually asymptomatic. They are often incidental findings from imaging workups for other medical issues or from the assessment of primary tumors in other locations. Diabetes insipidus is the most common symptom resulting from pituitary tumors, including pituitary metastases. A 56-year-old woman with primary lung adenocarcinoma underwent video-assisted thoracic bilobectomy. Regular follow-up was unremarkable until 15 months after surgery, when she presented with polyuria and polydipsia suggestive of diabetes insipidus. A pituitary mass was found on brain magnetic resonance imaging; the diagnosis of lung adenocarcinoma metastasized to the pituitary was confirmed by trans-sphenoidal surgery and biopsy of the pituitary mass. Diabetes insipidus and hormonal profiles are the key to recognize the existence of pituitary metastases, and patients with primary lung cancers presenting with diabetes insipidus should be evaluated for pituitary metastases.


Pituitary tumor Metastasis Lung cancer Diabetes insipidus 


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  1. [1]
    McCormick P.C., Post K.D., Kandji A.D., Hays A.P., Metastatic carcinoma to the pituitary gland, Br J Neurosurg., 1989, 3, 71–80PubMedCrossRefGoogle Scholar
  2. [2]
    Komninos J., Vlassopoulou V., Protopapa D., Korfias S., Kontogeorgos G., Sakas D.E., et al., Tumors metastatic to the pituitary gland: case report and literature review, J Clin Endocrinol Metab., 2004, 89, 574–580PubMedCrossRefGoogle Scholar
  3. [3]
    Rajput R., Bhansali A., Dutta P., Gupta S.K., Radotra B.D., Bhadada S., Pituitary metastasis masquerading as non-functioning pituitary adenoma in a woman with adenocarcinoma lung, Pituitary., 2006, 9, 155–157PubMedCrossRefGoogle Scholar
  4. [4]
    Sioutos P., Yen V., Arbit E., Pituitary gland metastases, Ann Surg Oncol., 1996, 3, 94–99PubMedCrossRefGoogle Scholar
  5. [5]
    Nelson P.B., Robinson A.G., Martinez A.J., Metastatic tumor of the pituitary gland, Neurosurgery., 1987, 21, 941–944PubMedCrossRefGoogle Scholar
  6. [6]
    Krol T.C., Wood W.S., Bronchogenic carcinoma and diabetes insipidus: case report and review, Cancer., 1982, 49, 596–599PubMedCrossRefGoogle Scholar
  7. [7]
    Morita A., Meyer F.B., Laws E.R. Jr., Symptomatic pituitary metastases, J Neurosurg., 1998, 89, 69–73PubMedCrossRefGoogle Scholar
  8. [8]
    Marin F., Kovacs K.T., Scheithauer B.W., Young W.F. Jr., The pituitary gland in patients with breast carcinoma: a histologic and immunocytochemical study of 125 cases, Mayo Clin Proc., 1992, 67, 949–956PubMedGoogle Scholar
  9. [9]
    Teears R.J., Silverman E.M., Clinicopathologic review of 88 cases of carcinoma metastatic to the pituitary gland, Cancer., 1965, 36, 216–220CrossRefGoogle Scholar
  10. [10]
    Branch C.L. Jr., Laws E.R. Jr., Metastatic tumors of the sella tunica masquerading as primary pituitary tumors, J Clin Endocrinol Metab., 1987, 65, 469–474PubMedCrossRefGoogle Scholar
  11. [11]
    Chandra V., McDonald L.W., Anderson R.J., Metastatic small cell carcinoma of the lung presenting as pituitary apoplexy and Cushing’s syndrome, J Neurooncol., 1984, 2, 59–66PubMedCrossRefGoogle Scholar
  12. [12]
    Sanno N., Teramoto A., Osamura R.Y., Genka S., Katakami H., Jin L., et al., A growth hormonereleasing hormone-producing pancreatic islet cell tumor metastasized to the pituitary is associated with pituitary somatotroph hyperplasia and acromegaly, J Clin Endocrinol Metab., 1997, 82, 2731–2737PubMedCrossRefGoogle Scholar
  13. [13]
    Jerome Marson V., Mazieres J., Groussard O., Garcia O., Berjaud J., Dahan M., et al., Expression of TTF-1 and cytokeratins in primary and secondary epithelial lung tumours: correlation with histological type and grade, Histopathology., 2004, 45, 125–134PubMedCrossRefGoogle Scholar
  14. [14]
    Coons S.W., Estrada S.I., Gamez R., White W.L., Cytokeratin CK 7 and CK 20 expression in pituitary adenomas, Endocr Pathol., 2005, 16, 201–210PubMedCrossRefGoogle Scholar

Copyright information

© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Chen-Hao Hsiao
    • 1
  • Chung-Yih Wang
    • 2
  • Ming-Teng Chung
    • 3
  • Ming-Sung Yang
    • 4
  1. 1.Department of SurgeryCheng Hsin General HospitalTaipeiTaiwan
  2. 2.Department of Radiation OncologyCheng Hsin General HospitalTaipeiTaiwan
  3. 3.Department of PathologyCheng Hsin General HospitalTaipeiTaiwan
  4. 4.Department of SurgeryCheng Hsin General HospitalTaipeiTaiwan

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