Central European Journal of Medicine

, Volume 5, Issue 5, pp 588–592 | Cite as

The effects of one-year simvastatin therapy on women’s bone mineral density

  • Aleksandar Dimic
  • Dimitrije Jankovic
  • Irena Jankovic
  • Todorka Savic
  • Nevena Karanovic
Research Article


Only few studies have reported that bone fracture risk is decreased in hypercholesterolemic postmenopausal women treated with statin therapy. Because of a lack of longitudinal studies on the effect of statins on bones, the aim of our investigation was to estimate the simvastatin therapy effects on bone mineral density in hypercholesterolemic postmenopausal women. Our investigation was carried out on 53 postmenopausal women with hypercholesterolemia. The women included in the study were divided into two groups. Group 1 was comprised of women with two or more (n=32) atherosclerosis risk factors, whereas group 2 had women with less than two (n=21) of these risk factors. All the women included in the study were placed on a hypocholesterolemic diet and the women in group 1 were additionally treated with 20 mg of simvastatin daily. The parameters of lipid status, body mass index, and L2–L4 densitometry were determined at baseline and then after one year. The simvastatin-treated group showed significant improvement of lipid parameters and increased bone mineral density. Finally, changes in bone mineral density between the groups showed significant differences (p<0.05). Although our investigation was carried out on a small group, our results showed a positive effect of the simvastatin therapy on the bone mineral density of postmenopausal women.


Bone mineral density Postmenopausal women Hypercholesterolemia Statins 


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Copyright information

© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Aleksandar Dimic
    • 1
    • 2
  • Dimitrije Jankovic
    • 2
  • Irena Jankovic
    • 2
  • Todorka Savic
    • 1
    • 2
  • Nevena Karanovic
    • 3
  1. 1.Treatment and Rehabilitation of Rheumatic and Cardiovascular Diseases “Niska Banja,”Institute for PreventionNiska BanjaSerbia
  2. 2.Medical FacultyUniversity in NisNisSerbia
  3. 3.Megatrend UniversityBelgradeSerbia

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