Central European Journal of Medicine

, Volume 6, Issue 1, pp 1–10 | Cite as

A short overview of vitamin C and selected cells of the immune system

  • Voja PavlovicEmail author
  • M. Sarac
Review Article


Vitamin C (ascorbic acid) is an essential water-soluble nutrient that primarily exerts its effect on a host defense mechanisms and immune homeostasis and is the most important physiological antioxidant. Stable intake of vitamin C is essential for life in humans because the body does not synthesize it. Even the numerous studies have demonstrated that vitamin C supplementation stimulates the immune system, prevents DNA damage and significantly decreases the risk of a wide range of pathologies; the potential protective mechanisms are still largely unknown. This review summarizes the recently known facts about the role of vitamin C on the selected cells of the immune system and potential molecular mechanisms involved. Further, in this review, many new data about the positive effects of vitamin C on the immune system, potential toxicological effects, vitamin C supplementation in disease development, as well as some proposed mechanisms of vitamin C activity, are discussed.


Vitamin C Immune system T-cells Neutrophils Dendritic cells 


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© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Institute of Physiology, Medical FacultyUniversity in NisNisSerbia
  2. 2.Medical FacultyUniversity in NisNisSerbia

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