Skip to main content
Log in

Prognosis of thyroid function after hemithyroidectomy

  • Research Article
  • Published:
Central European Journal of Medicine

Abstract

Identify criteria and create a risk scoring system to predict hypothyroidism after hemithyroidectomy. We have retrospectively studied 216 cases of patients with goiter who had undergone hemithyroidectomy from January 2002 to December 2007 at Vilnius University Hospital Santariškių Klinikos. Patients were divided into two groups according to their thyroid function after hemithyroidectomy: 168 (77.8%) patients’ thyroid function was normal (group A), 48 (22.2%) patients had symptoms of hypothyroidism (group B). The relationship between groups and parameters such as patients’ sex, age, patient’s weight, preoperative serum thyroid-stimulating hormone (TSH) level, weight of the remnant gland, ratio of the remaining thyroid gland weight to patient’s weight was statistically analysed. The patients’ mean age was 41.6 ± 14.1 years in group A and 52.9 ± 13.9 years in group B (p=0.0002). The mean preoperative TSH level was 0.79 ± 0.5 mU/L in group A, compared with 1.42 ± 1.00 mU/L in group B (p= 0.005). The mean ratio of the remaining thyroid gland weight to patient’s weight was 0.102 ± 0.053 g/kg in group A and 0.063 ± 0.027 g/kg in group B (p=0.04). The groups did not establish a significant difference between patients’ sex, patient’s weight or weight of the remaining gland. Patient’s age, preoperative serum TSH level, ratio of the remaining thyroid gland weight to patient’s weight is the main factors of hypothyroidism after hemithyroidectomy. A risk scoring system was created to predict hypothyroidism after hemithyroidectomy before the operation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Hegedus L. Clinical practice: the thyroid nodule, N Engl J Med. — 2004, vol. 351, no. 17, p. 1764–1771

    Article  PubMed  Google Scholar 

  2. Ross D.S. Nonpalpable thyroid nodules: managing an epidemic, J Clin Endocrinol Metab. — 2002, vol. 87, no. 5, p. 1938–1940

    Article  CAS  PubMed  Google Scholar 

  3. Cooper D.S., Doherty G.M., Haugen B.R. et al. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer, Thyroid. — 2006, vol. 16, no. 2, p.109–142

    Article  PubMed  Google Scholar 

  4. Gharib H., Papini E., Valcavi R. … et al. American Assosiation of Clinical Endocrinologists and Associazione Medici Endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules, Endocr Pract. — 2006, vol. 12, no. 1, p. 63–102

    PubMed  Google Scholar 

  5. Gharib H., Mazzaferri E.L. Thyroxine suppressive therapy in patients with nodular thyroid disease, Ann Intern Med. — 1998, vol. 128, no. 5, p. 386–394

    CAS  PubMed  Google Scholar 

  6. Moon H.G., Jung E.J., Park S.T. et al. Thyrotropin level and thyroid volume for prediction of hypothyroidism following hemithyroidectomy in an Asian patient cohort, World J Surg. — 2008, vol. 32, no. 11, p. 2503–2508

    Article  PubMed  Google Scholar 

  7. Sawin C.T. Subclinical hyperthyroidism and atrial fibrillation, Thyroid. — 2002, vol. 12, no. 6, p. 501–503

    Article  PubMed  Google Scholar 

  8. Al-Abadi A.C. Subclinical thyrotoxicosis, Postgrad Med J. — 2001, vol. 77, no. 903, p. 29–32

    Article  CAS  PubMed  Google Scholar 

  9. McHenry C.R., Slusarczyk S.J. Hypothyroidisim following hemithyroidectomy: incidence, risk factors, and management, Surgery. — 2000, vol. 128, no. 6, p. 994–998

    Article  CAS  PubMed  Google Scholar 

  10. Berglund J., Bondeson L., Christensen S.B., Tibblin S. The influence of different degrees of chronic lymphocytic thyroiditis on thyroid function after surgery for benign, non-toxic goitre, Eur J Surg. — 1991, vol. 157, no. 4, p. 257–260

    CAS  PubMed  Google Scholar 

  11. Koh Y.W., Lee S.W., Choi E.C. et al. Prediction of hypothyroidism after hemithyroidectomy: a biochemical and pathological analysis, Eur Arch Otorhinolaryngol. — 2008, vol. 265, no. 4, p. 453–457

    Article  PubMed  Google Scholar 

  12. Žeromskas P. Skydliaukės dydžio ir jos likučio po operacijos nustatymas: daktaro disertacija. — Vilnius, 2000. — 102 p

  13. Piper H.G., Bugis S.P., Wilkins G.E. et al. Detecting and defining hypothyroidism after hemithyroidectomy, Am J Surg. — 2005, vol. 189, no. 5, p. 587–591. (discussion 591)

    Article  PubMed  Google Scholar 

  14. Hedman I., Jansson S., Lindberg S. Need for thyroxine in patients lobectomised for benign thyroid disease as assessed by follow-up on average 15 years after surgery, Acta Chir Scand. — 1986, vol. 152, p. 481–486

    CAS  PubMed  Google Scholar 

  15. Mandel S.J. A 64-year-old woman with a thyroid nodule, JAMA. — 2004, vol. 292, no. 21, p. 2632–2642

    Article  CAS  PubMed  Google Scholar 

  16. Lombardi G., Panza N., Lupoli G. et al. Study of the pituitary-thyroid axis in euthyroid goiter after partial thyroidectomy, J Endocrinol Invest. — 1983, vol. 6, no. 6, p. 485–487

    CAS  PubMed  Google Scholar 

  17. Buchanan M.A., Lee D. Thyroid auto-antibodies, lymphocytic infiltration and the development of post-operative hypothyroidism following hemithyroidectomy for non-toxic nodular goitre, J R Coll Surg Edinb. — 2001, vol. 46, no. 2, p. 86–90

    CAS  PubMed  Google Scholar 

  18. Miller F.R., Paulson D., Prihoda T.J., Otto R.A. Risk factors for the development of hypothyroidism after hemithyroidectomy, Arch Otolaryngol Head Neck Surg. — 2006, vol. 132, no. 1, p. 36–38

    Article  PubMed  Google Scholar 

  19. Bang U., Blichert-Toft M., Petersen P.H. et al. Thyroid function after resection for nontoxic goitre with special reference to thyroid lymphocytic aggregation and circulating thyroid autoantibodies, Acta Endocrinol (Copenh). — 1985, vol. 109, p. 214–219

    CAS  Google Scholar 

  20. Seiberling K.A., Dutra J.C., Bajaramovic S. Hypothyroidism following hemithyroidectomy for benign nontoxic thyroid disease, Ear Nose Throat J. — 2007, vol. 86, no. 5, p. 295–299

    PubMed  Google Scholar 

  21. Su S.Y., Serpell J. Es16p hypothyroidism following hemithyroidectomy, ANZ J Surg. — 2007, vol. 77,suppl. 1, p. A24

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to D. Kazanavičius.

About this article

Cite this article

Beiša, V., Kazanavičius, D., Skrebūnas, A. et al. Prognosis of thyroid function after hemithyroidectomy. cent.eur.j.med 6, 152–157 (2011). https://doi.org/10.2478/s11536-010-0064-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2478/s11536-010-0064-z

Keywords

Navigation