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Central European Journal of Medicine

, Volume 5, Issue 6, pp 752–757 | Cite as

Hypovitaminosis D and cardiometabolic risk factors among non-obese youth

  • Nasser M. Al-Daghri
  • Omar S. Al-Attas
  • Majed S. Alokail
  • Khalid M Alkharfy
  • Mansour Yousef
  • Hesham M. Nadhrah
  • Abdulaziz Al-Othman
  • Yousef Al-Saleh
  • Shaun Sabico
  • George P. Chrousos
Research Article
  • 86 Downloads

Abstract

Hypovitaminosis D and increased cardiometabolic risk have been well established in adults. This study aims to determine whether or not vitamin D also influences cardiometabolic risk in children and adolescents. To test this hypothesis, we recruited 186 boys (mean age 12.4 ± 3.7 years) and 114 girls (11.6 ± 3.7) in a cross-sectional observational study. Anthropometrics were obtained and morning fasting blood samples were collected. Serum glucose and lipid profile were determined using routine methods. Serum 25-hydroxyvitamin D was quantified using an enzyme-linked immunosorbent assay. In our population, approximately 10% of subjects had severe 25-hydroxyvitamin D deficiency (< 12.5 nmol/L), while 50% of the boys and 40% of the girls had mild vitamin D deficiency (12.5–24.9 nmol/L). Circulating 25-hydroxyvitamin D concentrations were inversely correlated with age, body mass index (BMI), blood pressure, waist and hip circumferences and serum triglyceride concentrations, and positively associated with HDL-cholesterol. Age and systolic blood pressure were significant predictors of 25-hydroxyvitamin D, explaining about 30% of the variance (p = 0.0005). In conclusion, significant associations between serum 25-hydroxyvitamin D and cardiometabolic parameters support promising cardioprotective benefits from vitamin D sufficiency at an early age. Follow-up with prospective clinical intervention studies are needed to validate this hypothesis.

Keywords

25-Hydroxycholecalciferol Hypovitaminosis D Children 

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References

  1. [1]
    Molina J.A., Heng B.H., Global trends in cardiology and cardiothoracic surgery — an opportunity or a threat?, Ann. Acad. Med. Singapore 2009, 38, 541–545PubMedGoogle Scholar
  2. [2]
    Al-Nozha M.M., Abdullah M., Arafah M.R., Khalil M.Z., Khan N.B., Al-Mazrou Y.Y., et al., Hypertension in Saudi Arabia, Saudi Med. J. 2007, 28,77–84PubMedGoogle Scholar
  3. [3]
    Al-Nozha M.M., Arafah M.R., Al-Maatouq M.A., Khalil M.Z., Khan N.B., Al-Marzouki K., et al., Hyperlipidemia in Saudi Arabia, Saudi Med. J. 2008, 29, 282–287PubMedGoogle Scholar
  4. [4]
    Al-Nozha M., Al-Khadra A., Arafah M.R., Al-Maatouq M.A., Khalil M.Z., Khan N.B., et al., Metabolic syndrome in Saudi Arabia, Saudi Med. J. 2005, 26, 1918–1925PubMedGoogle Scholar
  5. [5]
    El-Mouzan M.I., Al-Herbish A., Al-Salloum A.A., Al-Omar A.A., Qurachi M.M., Trends in the nutritional status of Saudi children, Saudi Med. J. 2008, 29, 884–887PubMedGoogle Scholar
  6. [6]
    Al-Hazzaa H.M., Prevalence of physical inactivity in Saudi Arabia: a brief review, East Mediterr. Health J. 2004, 10, 663–670PubMedGoogle Scholar
  7. [7]
    Bawazeer N., Al-Daghri N., Valsamakis G., Al-Rubeaan K., Valsamakis G, Sabico S., et al., Sleep duration and quality associated with obesity among Arab children, Obesity 2009, 17, 2251–2253CrossRefPubMedGoogle Scholar
  8. [8]
    Camhi S.M., Katzmarzyk P.T., Tracking of cardiometabolic risk factor clustering from childhood to adulthood, Int. J. Pediatr. Obes. 2009, 1–8Google Scholar
  9. [9]
    Jiang S., Bao Y., Hou X., Fang O., Wang C., Pan J., et al., Serum C-reactive protein and risk of cardiovascular events in middle-aged and older Chinese population, Am. J. Cardiol. 2009, 103, 1727–1731CrossRefPubMedGoogle Scholar
  10. [10]
    Zhou J., Austin R.C., Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms, Biofactors 2009, 35, 120–129CrossRefPubMedGoogle Scholar
  11. [11]
    Mithal A., Wahl D.A., Bonjour J.P., Burckhardt P., Dawson-Hughes B., Eisman J.A., et al., Global vitamin D status and determinants of hypovitaminosis D, Osteoporosis Int. 2009, 20, 1807–1820CrossRefGoogle Scholar
  12. [12]
    Judd S.E., Tangpricha V., Vitamin D deficiency and risk of cardiovascular disease, Am. J. Med. Sci. 2009, 338, 40–44CrossRefPubMedGoogle Scholar
  13. [13]
    Forouhi N.G., Luan J., Cooper A., Boucher B.J., Wareham N.J., Baseline serum 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990–2000, Diabetes 2008, 57, 2619–2625CrossRefPubMedGoogle Scholar
  14. [14]
    Moradzadeh K., Larijani B., Keshtar A., Hossein-Nezhad A., Rajabian R., Nabipour I., et al., Normative values of vitamin D among Iranian population: a population based study, Int. J. Osteoporosis Metabolic Disorders 2008, 1, 8–15CrossRefGoogle Scholar
  15. [15]
    Rovner A.J., O’Brien K.O., Hypovitaminosis D among healthy children in the United States, Arch. Pediatr. Adolesc. Med. 2008, 162, 513–519CrossRefPubMedGoogle Scholar
  16. [16]
    Bener A., Al-Ali M., Hoffman G.F., High prevalence of vitamin D deficiency in young children in a highly sunny humid country: a global health problem, Minerva Pediatr. 2009, 61, 15–22PubMedGoogle Scholar
  17. [17]
    Sedrani S.H., Elidrissy A.W., El Arabi K.M., Sunlight and vitamin D status in normal Saudi subjects, Am. J. Clin. Nutr. 1983, 38, 129–132PubMedGoogle Scholar
  18. [18]
    Al-Atawi M.S., Al-Alwan I.A., Al-Mutair A.N., Tanim H.M., Al-Jurayyan N.A., Epidemiology of nutritional rickets in children, Saudi J. Kidney Dis. Transpl. 2009, 20, 260–265PubMedGoogle Scholar
  19. [19]
    McCarty M.F., Poor vitamin D status may contribute to high risk for insulin resistance, obesity and cardiovascular disease in Asian Indians, Med. Hypotheses 2009, 72, 647–651CrossRefPubMedGoogle Scholar
  20. [20]
    Nemerovski C.W., Dorsch M.P., Simpson R.U., Bone H.G., Aaronson K.D., Bleske B.E., Vitamin D and cardiovascular disease, Pharmacotherapy 2009, 29, 691–708CrossRefPubMedGoogle Scholar
  21. [21]
    Matias P.J., Ferreira C., Jorge C., Borges M., Aires I., Amaral T., 25-Hydroxyvitamin D3, arterial calcifications and cardiovascular risk markers in haemodialysis patients, Nephrol. Dial. Transplant 2009, 24, 611–618CrossRefPubMedGoogle Scholar
  22. [22]
    Alemzadeh R., Kichler J., Babar G., Calhoun M., Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity and season, Metabolism 2008, 57, 183–191CrossRefPubMedGoogle Scholar
  23. [23]
    Gannage-Yared M.H., Chedid R., Khalife S., Azzi E., Zoghbi F., Halaby G., Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population, Eur. J. Endocrinol. 2009, 160, 965–971CrossRefPubMedGoogle Scholar
  24. [24]
    Forman J.P., Giovannucci E., Holmes M.D., Bischoff-Ferrari H.A., Tworoger S.S., Willett W.C., et al., Plasma 25-hydroxyvitamin D levels and risk of incident hypertension, Hypertension 2007, 49, 1063–1069CrossRefPubMedGoogle Scholar
  25. [25]
    Hsia J., Heiss G., Ren H., Allison M., Dolan N.C., Greenland P., et al., Calcium/vitamin D supplementation and cardiovascular events, Circulation 2007, 115, 846–854CrossRefPubMedGoogle Scholar

Copyright information

© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Nasser M. Al-Daghri
    • 1
  • Omar S. Al-Attas
    • 1
  • Majed S. Alokail
    • 1
  • Khalid M Alkharfy
    • 2
  • Mansour Yousef
    • 3
  • Hesham M. Nadhrah
    • 3
  • Abdulaziz Al-Othman
    • 4
  • Yousef Al-Saleh
    • 5
  • Shaun Sabico
    • 1
  • George P. Chrousos
    • 1
    • 6
  1. 1.Biochemistry Department, College of ScienceKing Saud University, RiyadhRiyadhKingdom of Saudi Arabia
  2. 2.Clinical Pharmacy Department, College of PharmacyKing Saud UniversityRiyadhKingdom of Saudi Arabia
  3. 3.Health Affairs for Riyadh RegionMinistry of HealthRiyadhKingdom of Saudi Arabia
  4. 4.College of Applied Medical SciencesKing Saud UniversityRiyadhKingdom of Saudi Arabia
  5. 5.King Abdulaziz Medical CityRiyadhKingdom of Saudi Arabia
  6. 6.First Department of PediatricsAthens University Medical SchoolAthensGreece

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