Central European Journal of Medicine

, Volume 5, Issue 6, pp 752–757 | Cite as

Hypovitaminosis D and cardiometabolic risk factors among non-obese youth

  • Nasser M. Al-Daghri
  • Omar S. Al-Attas
  • Majed S. Alokail
  • Khalid M Alkharfy
  • Mansour Yousef
  • Hesham M. Nadhrah
  • Abdulaziz Al-Othman
  • Yousef Al-Saleh
  • Shaun Sabico
  • George P. Chrousos
Research Article


Hypovitaminosis D and increased cardiometabolic risk have been well established in adults. This study aims to determine whether or not vitamin D also influences cardiometabolic risk in children and adolescents. To test this hypothesis, we recruited 186 boys (mean age 12.4 ± 3.7 years) and 114 girls (11.6 ± 3.7) in a cross-sectional observational study. Anthropometrics were obtained and morning fasting blood samples were collected. Serum glucose and lipid profile were determined using routine methods. Serum 25-hydroxyvitamin D was quantified using an enzyme-linked immunosorbent assay. In our population, approximately 10% of subjects had severe 25-hydroxyvitamin D deficiency (< 12.5 nmol/L), while 50% of the boys and 40% of the girls had mild vitamin D deficiency (12.5–24.9 nmol/L). Circulating 25-hydroxyvitamin D concentrations were inversely correlated with age, body mass index (BMI), blood pressure, waist and hip circumferences and serum triglyceride concentrations, and positively associated with HDL-cholesterol. Age and systolic blood pressure were significant predictors of 25-hydroxyvitamin D, explaining about 30% of the variance (p = 0.0005). In conclusion, significant associations between serum 25-hydroxyvitamin D and cardiometabolic parameters support promising cardioprotective benefits from vitamin D sufficiency at an early age. Follow-up with prospective clinical intervention studies are needed to validate this hypothesis.


25-Hydroxycholecalciferol Hypovitaminosis D Children 


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Copyright information

© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Nasser M. Al-Daghri
    • 1
  • Omar S. Al-Attas
    • 1
  • Majed S. Alokail
    • 1
  • Khalid M Alkharfy
    • 2
  • Mansour Yousef
    • 3
  • Hesham M. Nadhrah
    • 3
  • Abdulaziz Al-Othman
    • 4
  • Yousef Al-Saleh
    • 5
  • Shaun Sabico
    • 1
  • George P. Chrousos
    • 1
    • 6
  1. 1.Biochemistry Department, College of ScienceKing Saud University, RiyadhRiyadhKingdom of Saudi Arabia
  2. 2.Clinical Pharmacy Department, College of PharmacyKing Saud UniversityRiyadhKingdom of Saudi Arabia
  3. 3.Health Affairs for Riyadh RegionMinistry of HealthRiyadhKingdom of Saudi Arabia
  4. 4.College of Applied Medical SciencesKing Saud UniversityRiyadhKingdom of Saudi Arabia
  5. 5.King Abdulaziz Medical CityRiyadhKingdom of Saudi Arabia
  6. 6.First Department of PediatricsAthens University Medical SchoolAthensGreece

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