Prevalence and recurrence rate of colonic lesions in acromegalic patients
Acromegaly is associated with an increased prevalence of colonic polyps. The aim of this study was to evaluate the prevalence and recurrence rate of colonic polyps in acromegalic patients. Ninety-six acromegalic patients and 100 irritable bowel syndrome patients (IBS) were enrolled in the study. Twenty patients who were cured exclusively by surgery, and 20 patients that could not be hormonally controlled were re-examined colonoscopically after 36 months. Twenty-nine of 96 acromegalic patients (30.2%) had colonic polyps. In the IBS group, 10 (10.0%) had colonic polyps. The prevalence of colonic polyps was significantly higher in acromegaly. The group of acromegalic patients with and without polyps did not differ significantly with regard to plasma GH, IGF-I, fasting insulin levels and glycemic status. The presence of colonic polyps was correlated with increased patient age and male gender. We did not observe a difference in terms of polyp recurrence frequencies in the patients cured by surgery compared to uncontrolled patients. Acromegalic patients have a higher prevalence of colonic polyps than that of control subjects. We could not identify any factors that could predict polyps within the acromegalic patients - but age and male sex.
KeywordsAcromegaly Colon polyp IGF-I GH Insulin
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- Bjork J., Nilsson J., Hultcrantz R., Johansson C., Growth-regulatory effects of sensory neuropeptides, epidermal growth factor, insulin, and somatostatin on the nontransformed intestinal epithelial cell line IEC-6 and the colon cancer cell line HT 29, Scand J Gastroenterol., 1993, 28, 879–884CrossRefPubMedGoogle Scholar
- Levin B., Lieberman DA., McFarland B., Andrews KS., Brooks D., Bond J., et al., American Cancer Society Colorectal Cancer Advisory Group; US Multi-Society Task Force; American College of Radiology Colon Cancer Committee. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology., 2008, 134, 1570–1595CrossRefPubMedGoogle Scholar
- Juul A., Pedersen SA., Sørensen S., Winkler K., Jørgensen JO., Christiansen JS., et al., Growth hormone (GH) treatment increases serum insulin-like growth factor binding protein-3, bone isoenzyme alkaline phosphatase and forearm bone mineral content in young adults with GH deficiency of childhood onset, Eur J Endocrinol., 1994, 131, 41–49CrossRefPubMedGoogle Scholar
- Cohen P., Fielder PJ., Hasegawa Y., Frisch H., Giudice LC., Rosenfeld RG., Clinical aspects of insulin-like growth factor binding proteins, Acta Endocrinol (Copenh)., 1991, 124, 74–85Google Scholar
- Nam SY., Lee EJ., Kim KR., Cha BS., Song YD., Lim SK., et al., Effect of obesity on total and free insulin-like growth factor (IGF)-I and their relationship to IGFbinding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone, Int J Obes Relat Metab Disord., 1997, 21, 355–359CrossRefPubMedGoogle Scholar
- Pawlikowski M., Lachowicz L., Kunert-Radek J., Winczyk K., Janiszewska G., Szkudlarek J., Differential effects of somatostatin and its analog on protein tyrosine kinases activity in the rat pituitary and the murine colonic tumors, Biochem Biophys Res Commun., 1998, 246, 375–377CrossRefPubMedGoogle Scholar