Association of osteoprotegerin and rankl levels with insulin resistance in pubertal obese children
- 56 Downloads
Osteoprotegerin (OPG)/“receptor activator of nuclear factor kappa B-ligand” (RANKL) system has an important role in the remodeling of bone through regulation of osteoclastogenesis. We aimed to detect OPG and RANKL levels, particularly in obese children in the pubertal period and to investigate whether these parameters correlate with insulin resistance in childhood. Our study included 66 obese children ranging in age from 9.1 to 16 years, and 22 non-obese children ranging in age from 10.5 to 16 years. Blood glucose, insulin, total cholesterol, HDL cholesterol, and LDL cholesterol levels were measured for all cases; HOMA-IR, Quicki index and atherogenic index were calculated. Serum OPG and RANKL levels were also measured. OPG and RANKL levels did not show any difference between obese and non-obese children (P>.05). No difference in these 2 parameters were observed among the children with and without insulin resistance (P>.05). No correlation could be established between the OPG, the HOMA-IR, Quick and atherogenic indices. Obesity and insulin resistance are believed to show their effect in the later period of life to become able to change some of the parameters.
KeywordsHenoch-Schönlein purpura Nephrotic syndrome Adulthood
Unable to display preview. Download preview PDF.
- Alemzadeh R., Rising R., Lifshitz F., Obesity in Children, In: Lifshitz F., Editor. Pediatric Endocrinology. New York: Healthcare, 2007, 1–36Google Scholar
- Güngör N., Arslanian S.A., Nutritional disorders, In: Sperling M.A., Editor. Pediatric Endocrinology. Philadelphia: Saunders, 2002, 689–724Google Scholar
- Min H., Morony S., Sarosi I., Dunstan C.R., Capparelli C., Scully S., et al., Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis., J. Exp. Med., 2000, 192, 463–474CrossRefPubMedGoogle Scholar
- Keskin M., Kurtoglu S., Kendirci M., Atabek M.E., Yazici C., Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents., Pediatrics, 2005, 115, e500–503CrossRefPubMedGoogle Scholar
- Buzi F., Maccarinelli G., Guaragni B., Ruggeri F., Radetti G., Meini A., et al., Serum osteoprotegerin and receptor activator of nuclear factors kB (RANKL) concentrations in normal children and in children with pubertal precocity, Turner’s syndrome and rheumatoid arthritis., Clin. Endocrinol. (Oxf)., 2004, 60, 87–91CrossRefGoogle Scholar
- Oh E.S., Rhee E.J., Oh K.W., Lee W.Y., Baek K.H., Yoon K.H., et al., Circulating osteoprotegerin levels are associated with age, waist-to-hip ratio, serum total cholesterol, and low-density lipoprotein cholesterol levels in healthy Korean women., Metabolism, 2005, 54, 49–54CrossRefPubMedGoogle Scholar
- Gannagé-Yared M.H., Yaghi C., Habre B., Khalife S., Noun R., Germanos-Haddad M., et al., Osteoprotegerin in relation to body weight, lipid parameters insulin sensitivity, adipocytokines, and C-reactive protein in obese and non-obese young individuals: results from both cross-sectional and interventional study., Eur. J. Endocrinol., 2008, 158, 353–359CrossRefPubMedGoogle Scholar
- Rhee E.J., Oh K.W., Jung C.H., Lee W.Y., Oh E.S., Yun E.J., et al., The relationship between four single nucleotide polymorphisms in the promoter region of the osteoprotegerin gene and aortic calcification or coronary artery disease in Koreans., Clin. Endocrinol. (Oxf)., 2006, 64, 689–697CrossRefGoogle Scholar