Central European Journal of Medicine

, Volume 4, Issue 3, pp 379–381 | Cite as

Primary prevention of nephropathy in obese type 2 diabetic patient

  • Plamen H. Yovchevski
  • Zhivka A. Boneva
Case Report


We report a case of a 36-year-old obese man who presented with newly onset diabetes mellitus type 2 and hypertension. The estimated value of glomerular filtration rate — 203.7 ml/min was associated with the patient being at high risk of developing progressive renal disease. In this case, in order to prevent nephropathy, the preferred therapy was a gradual bodyweight reduction. A low-calorie diet providing an 800 kcal/day deficit was recommended to the patient, as well as an increase in physical activity. After a total weight reduction of 50 kg (33% of initial bodyweight), the patient’s glomerular filtration, body mass index, and blood pressure normalized without any drug therapy. Glucose, blood pressure and lipid target levels can only be simultaneously achieved through body-weight reduction. In the presented case, we show the beneficial effects of bodyweight reduction, and dietary and physical activity changes on high glomerular filtration rate. Bodyweight reduction stops the cascade of events that are caused by glomerular hyperfiltration and the progression toward irreversible renal damage.


Diabetes mellitus type 2 Glomerular hyperfiltration Diabetic nephropathy Primary prevention 


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Copyright information

© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Department of NephrologyMedical Institute of Ministry of InteriorSofiaBulgaria
  2. 2.Department of EndocrinologyMedical Institute of Ministry of InteriorSofiaBulgaria

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