Central European Journal of Medicine

, Volume 4, Issue 3, pp 391–394 | Cite as

Unusual case of calciphylaxis associated with digital necrosis and penile necrosis

  • Fatih Uygur
  • Celalettin Sever
  • Nurettin Noyan
  • Zafer Küçükodaci
Case Report


Calciphylaxis is a relatively rare disorder associated with calcification of small- and medium-sized blood vessels, progressive ischemic skin necrosis, and ulcerations. This situation is a potentially life-threatening condition seen in patients with endstage renal disease (ESRD). A 64-year-old man with ESRD on dialysis for 6 years was admitted to our clinic with severe pain and partial necrosis of some fingers on his right hand. In addition, the patient had suffered from diabetes for 22 years and had been on insulin therapy for 17 years. His necrotic fingers were amputated. After two months, necrosis on his glans penis developed despite medical management. Penile amputation was performed. In this case report, the patient serves to illustrate the spectrum of complications with which calciphylaxis can be associated.


Calciphylaxis Penile necrosis Digital necrosis 


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  1. [1]
    Androgue J, Frazier MR, Zeluff B, Suki WN. Systemic calciphylaxis revisited. AmJ Nephrol 1: 177–183, 1981CrossRefGoogle Scholar
  2. [2]
    Fujioka H, Hashimoto K, Endou N, Asami K. A case of soft tissue necrosis by calcific uremic arteriopathy (calciphylaxis). Journal of Japan Society of Plastic and Reconstructive Surgery 22:837–842, 2002 (in Japanese)Google Scholar
  3. [3]
    Wilmer WA and Magro CM: Calciphylaxis: emerging concepts in prevention, diagnosis, and treatment. Semin Dial 2002,15:172–186PubMedCrossRefGoogle Scholar
  4. [4]
    Budisavljevic MN, Cheek D, Ploth DW. Calciphylaxis in chronic renal failure. J Am Soc Nephrol 7: 978–982, 1996PubMedGoogle Scholar
  5. [5]
    Fine A and Zacharias J: Calciphylaxis is usually non-ulcerating: risk factors, outcome and therapy. Kidney Int 2002, 61:2210–2217PubMedCrossRefGoogle Scholar
  6. [6]
    Stein M, Anderson C, Ricciardi R, Chamberlin JW, Lerner SE, Glicklich D. Penile gangrene associated with chronic renal failure: report of 7 cases and review of the literature. J Urol 152: 2014–2016, 1994PubMedGoogle Scholar
  7. [7]
    Seoane VMA, Terán HM, Presno BM, Vásquez DA. Calcifilaxis de Pene. Rev Mex Urol 64: 89–94, 2004Google Scholar
  8. [8]
    Mathew D. SORENSEN, Layron O. LONG, Hunter WESSELLS, James K. KUAN. Monckeberg’s calciphylaxis with necrosis of the glans penis: A case presentation. Hemodialysis International 2007; 11:300–302PubMedCrossRefGoogle Scholar
  9. [9]
    Naoya Igaki, Rintarou Moriguchi, Yusi Hirota, Makoto Sakai, Hiroyuki Akiyama, Fumihiko Tamada, Munetada Oimomiand Takeo Goto. Calciphylaxis in a Patient with End-Stage Renal Disease Secondary to Systemic Lupus Erythematosus Associated. Internal Medicine 40: 1232–1237Google Scholar
  10. [10]
    Griffith TD, Hartle JE, Quarles LD. Calciphylaxis. In UpTo- Date 12. 1, Rose BD (Ed), UpToDate, Wellesley, MA, 2004Google Scholar
  11. [11]
    Tamura M, Hiroshige K, Osajima A, Soejima M, Takasugi M, Kuroiwa A. Adialysis patient with systemic calciphylaxis exhibiting rapidly progressive visceral ischemia and acral gangrene. Intern Med 34: 908–912,1995PubMedCrossRefGoogle Scholar
  12. [12]
    Weiner DM, Lowe FC. Surgical management of ischemic penile gangrene in diabetics with endstage atherosclerosis. J Urol. 1996; 155:926–929PubMedCrossRefGoogle Scholar

Copyright information

© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Fatih Uygur
    • 1
  • Celalettin Sever
    • 1
  • Nurettin Noyan
    • 1
  • Zafer Küçükodaci
    • 2
  1. 1.Department of Plastic and Reconstructive Surgery and Burn Unit, Gülhane Military Medical Academy and Medical FacultyHaydarpaşa Training HospitalIstanbulTurkey
  2. 2.Department of Pathology, Gülhane Military Medical Academy and Medical FacultyHaydarpaşa Training HospitalIstanbulTurkey

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