Central European Journal of Medicine

, Volume 4, Issue 3, pp 331–336 | Cite as

How safe is the use of prosthetic materials in the repair of abdominal-wall defects in malnourished subjects?

  • Mehmet Ali Karahan
  • Hakan Kulacoglu
  • Duray Seker
  • Zafer Ergul
  • Aysel Kiziltay
  • Demet Yilmazer
  • Ozge Captug
  • Alper Yavuz
  • Kemal Serbetci
  • Hasan Bilgili
  • Nesrin Hasirci
Research Article


Incisional hernias and abdominal-wall defects consume large amounts of healthcare resources. Use of mesh is effective in treatment of these disorders and can decrease the rate of recurrence. This experimental study focused on the safety of mesh use in the setting of malnutrition, a condition that impairs wound healing. Rats were divided into two groups: normally fed and food-restricted. An abdominal-wall defect, 2 by 2 cm, was covered with polypropylene mesh, 2.5 by 2.5 cm. After sacrifice of the rats at the 21st and 60th days, tissue samples were sent for tensiometric and histopathological studies. No significant difference in infectious complications was observed between the two groups. Tensiometry revealed no significant differences between the groups. On histopathological examination, the only difference noted was in the vascularization scores of normally fed rats. For malnourished subjects that survived after surgery, the use of polypropylene mesh appeared safe in the closure of abdominal-wall defects, with no increase in infection rate and satisfactory wound healing.


Hernia repair Mesh Wound healing Tensile strength Malnutrition 


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Copyright information

© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Mehmet Ali Karahan
    • 1
  • Hakan Kulacoglu
    • 1
  • Duray Seker
    • 1
  • Zafer Ergul
    • 1
  • Aysel Kiziltay
    • 2
  • Demet Yilmazer
    • 3
  • Ozge Captug
    • 4
  • Alper Yavuz
    • 1
  • Kemal Serbetci
    • 5
  • Hasan Bilgili
    • 4
  • Nesrin Hasirci
    • 6
  1. 1.Deparment of SurgeryDiskapi Yildirim Beyazit Teaching and Research HospitalAnkaraTurkey
  2. 2.Grad. Dept. BiotechnologyMiddle East Technical UniversityAnkaraTurkey
  3. 3.Deparment of PathologyDiskapi Yildirim Beyazit Teaching and Research HospitalAnkaraTurkey
  4. 4.Department of SurgeryAnkara University Faculty of Veterinary MedicineAnkaraTurkey
  5. 5.Baskent University Faculty of Biomedical EngineeringAnkaraTurkey
  6. 6.Dept. Chemistry, Grad. Dept. Biotechnology, Grad Dept.Biomedical EngineeringMiddle East Technical UniversityAnkaraTurkey

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