Central European Journal of Medicine

, Volume 4, Issue 2, pp 164–170 | Cite as

Benefit of antibiotic therapy on pouchitis after ileal pouch anal anastomosis: A systematic review and meta-analysis of clinical trials

  • Behzad Elahi
  • Shekoufeh Nikfar
  • Saeed Derakhshani
  • Mohammad Vafaie
  • Mohammad Abdollahi
Research Article


The aim of the study was to evaluate and collect current evidence on the effect of antibiotics in pretreatment of pouchitis after restorative ileal pouch anal anastomosis (IPAA). Pubmed, Embase, Web of Science, Scopus, and Cochrane Library databases were searched between 1966 and July 2008; and relevant clinical trials extracted, reviewed, and validated according to the study protocol. The outcome of interest was clinical improvement after treatment. Nine randomized, placebo-controlled clinical trials were found relevant and studied but 3 of them with 70 patients were entered into meta-analysis. Pooling of the results from these trials yielded an odds ratio of 15.96 with a 95% CI of 4.20–60.70, indicating a significant OR (p<0.0001) in treatment group in comparison to the placebo group. In conclusion, the meta-analysis confirms benefit of antibiotics in management of pouchitis after IPAA operation.


Meta-analysis Ileal pouch anal anastomosis Antibiotic Pouchitis 


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Copyright information

© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Behzad Elahi
    • 1
  • Shekoufeh Nikfar
    • 2
  • Saeed Derakhshani
    • 3
  • Mohammad Vafaie
    • 3
  • Mohammad Abdollahi
    • 4
  1. 1.Division of Neurology, Institute of Medical SciencesUniversity of TorontoTorontoCanada
  2. 2.Food and Drug Affairs, and Food & Drug Laboratory Research CenterMinistry of Health & Medical EducationTehranIran
  3. 3.Baharan Coloproctology Surgical ClinicTehranIran
  4. 4.Faculty of Pharmacy, and Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehranIran

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