Successful management of mild atopic dermatitis in adults with probiotics and emollients

Abstract

Atopic dermatitis is characterized by impaired skin and mucous membrane barrier function. Measures improving barrier integrity decrease the influence of environmental factors that might exacerbate inflammation. Ten adult patients with mild-to-moderate atopic dermatitis consumed for three months fermented with potent antioxidative probiotic, L. fermentum ME-3 (DSM 14241) goat milk 200 mg/day. A control group consisted of six patients, not supplemented by probiotic. All patients used emollients regularly. Skin iron levels, glutathione redox ratios (GSSG/GSH), diene conjugate (DC) amounts, blood glutathione status, oxidized low-density lipoprotein (oxLDL), and total antioxidativity was measured at the baseline and after three months. A significant decrease in skin iron levels, DC amounts, and glutathione redox ratio occurred in the probiotic-supplemented group compared to the control group (P < 0.05 for all indices). In the same group, blood levels of oxLDL decreased (p < 0.05), and GSH levels increased (P < 0.001) with concomitant improvement in the GSSG/GSH ratio. Blood antioxidativity markers also showed an improvement. The results of our study demonstrate that regular use of probiotics with antioxidative properties coupled with the use of lipid-containing emollients considerably decreases inflammation and concomitant oxidative stress in adult patients with mild-to-moderate atopic dermatitis. This effect was observed both in the skin and in the blood.

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Abbreviations

AD:

atopic dermatitis

DC:

diene conjugates

GSH:

reduced glutathione

GSSG:

oxidized glutathione

GSSG/GSH:

glutathione redox ratio

OxS:

oxidative stress

TAA:

total antioxidative activity

TAC:

total antioxidant capacity

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Correspondence to Sirje Kaur.

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Kaur, S., Kullisaar, T., Mikelsaar, M. et al. Successful management of mild atopic dermatitis in adults with probiotics and emollients. cent.eur.j.med 3, 215–220 (2008). https://doi.org/10.2478/s11536-008-0022-1

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Keywords

  • Atopic dermatitis
  • Oxidative stress
  • Glutathione redox ratio
  • OxLDL
  • L. fermentum ME-3