Central European Journal of Medicine

, Volume 3, Issue 2, pp 215–220 | Cite as

Successful management of mild atopic dermatitis in adults with probiotics and emollients

  • Sirje KaurEmail author
  • Tiiu Kullisaar
  • Marika Mikelsaar
  • Maigi Eisen
  • Aune Rehema
  • Tiiu Vihalemm
  • Kersti Zilmer
  • Mihkel Zilmer
Research Article


Atopic dermatitis is characterized by impaired skin and mucous membrane barrier function. Measures improving barrier integrity decrease the influence of environmental factors that might exacerbate inflammation. Ten adult patients with mild-to-moderate atopic dermatitis consumed for three months fermented with potent antioxidative probiotic, L. fermentum ME-3 (DSM 14241) goat milk 200 mg/day. A control group consisted of six patients, not supplemented by probiotic. All patients used emollients regularly. Skin iron levels, glutathione redox ratios (GSSG/GSH), diene conjugate (DC) amounts, blood glutathione status, oxidized low-density lipoprotein (oxLDL), and total antioxidativity was measured at the baseline and after three months. A significant decrease in skin iron levels, DC amounts, and glutathione redox ratio occurred in the probiotic-supplemented group compared to the control group (P < 0.05 for all indices). In the same group, blood levels of oxLDL decreased (p < 0.05), and GSH levels increased (P < 0.001) with concomitant improvement in the GSSG/GSH ratio. Blood antioxidativity markers also showed an improvement. The results of our study demonstrate that regular use of probiotics with antioxidative properties coupled with the use of lipid-containing emollients considerably decreases inflammation and concomitant oxidative stress in adult patients with mild-to-moderate atopic dermatitis. This effect was observed both in the skin and in the blood.


Atopic dermatitis Oxidative stress Glutathione redox ratio OxLDL L. fermentum ME-3 



atopic dermatitis


diene conjugates


reduced glutathione


oxidized glutathione


glutathione redox ratio


oxidative stress


total antioxidative activity


total antioxidant capacity


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Copyright information

© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Sirje Kaur
    • 1
    Email author
  • Tiiu Kullisaar
    • 2
  • Marika Mikelsaar
    • 3
  • Maigi Eisen
    • 1
  • Aune Rehema
    • 2
  • Tiiu Vihalemm
    • 2
  • Kersti Zilmer
    • 2
  • Mihkel Zilmer
    • 2
  1. 1.Clinic of Dermatology, Faculty of MedicineUniversity of TartuTartuEstonia
  2. 2.Institute of Biochemistry, Faculty of MedicineUniversity of TartuTartuEstonia
  3. 3.Institute of Microbiology, Faculty of MedicineUniversity of TartuTartuEstonia

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