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Detection and identification of atypical quetiapine metabolite in urine

  • Research Article
  • Published:
Central European Journal of Medicine

Abstract

Quetiapine fumarate (Seroquel®) is an atypical antipsychotic dibenzothiazepine derivative. Due to its extensive hepatic metabolism and low level of unchanged excretion (< 1%) the routine toxicological drug-screening analyses of urine often leads to false negative results. In the present study, we report that a newly identified metabolite of quetiapine, N-desalkylquetiapine, can be used as an indicative marker of quetiapine-intake in urine using common GC-MS screening procedure. The structure of the mentioned metabolite was solved from the mass-spectrum obtained and the quetiapine presence was proved by consequent HPLC plasma analysis.

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Authors and Affiliations

  1. Clinic of Emergency Toxicology and Allergology, Military Medical Academy, 3 G. Sofiiski Str, 1603, Sofia, Bulgaria

    Vasil N. Atanasov & Kamen P. Kanev

  2. Laboratory of Bioinorganic and Bioanalytical Chemistry, Department of Analytical Chemistry, Faculty of Chemistry, Sofia University, 1 J. Bourchier Ave., 1164, Sofia, Bulgaria

    Vasil N. Atanasov & Mariana Io. Mitewa

Authors
  1. Vasil N. Atanasov
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  2. Kamen P. Kanev
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  3. Mariana Io. Mitewa
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Correspondence to Mariana Io. Mitewa.

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Atanasov, V.N., Kanev, K.P. & Mitewa, M.I. Detection and identification of atypical quetiapine metabolite in urine. cent.eur.j.med 3, 327–331 (2008). https://doi.org/10.2478/s11536-008-0015-0

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  • DOI: https://doi.org/10.2478/s11536-008-0015-0

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