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The cultural history of wine - theoretical background to wine therapy

Abstract

The knowledge of grape and wine is as old as the cultural history of mankind. Moderate consumption of wine can be beneficial in healthy individuals. It is also known from ancient times that it can cause acute and chronic damage when consumed in great quantities. The disinfectant effect of its use in ointments has been observed already in the antiquity. Polyphenols, among them resveratrol, have generated a great amount of scientific research due to their in vivo and in vitro antioxidant capabilities. For decades, red wine was thought to have beneficial effects on cardiovascular health. This relation was clearly established in the French Paradox phenomenon as well as in the Mediterranean diet. The French Paradox is defined as a low incidence of coronary heart disease, while consuming a diet rich in saturated fat. The cause of this phenomenon is the usually wine drinking in small quantity, supposingly in the consequence of polypenols in red wine. The use of ointments containing polyphenols of wine and the cosmetic treatments with them can be advantageous in the treatment and prevention of some diseases of the skin and the joints, due to its free radical scavenging effect. In healthy individuals the consumption of a moderate amount of 1 to 2 dl wine a day may reduce the mortality of cardiovascular diseases. However, also this quantity can be associated with detrimental effects in pregnant women, in children and in patients with various organic, particularly hepatic, diseases as well as in case of regular administration of certain medicines.

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References

  1. K. Berger, U.A. Ajani, C. S. Kase, J.M. Gaziano, J.E. Buring, R.J. Glynn, C.H. Hennekens: “Light-to-moderate alcohol consumption and the risk of stroke among U. S. Male phyicians”, New. Engl. J. Med., Vol. 341, (1999), pp. 1557–1567.

    PubMed  Article  CAS  Google Scholar 

  2. J. Feher and A. Lugasi: “Antioxidant characteristics of a newly developed vermouth wine (Hung.)”, Orv Hetil., Vol. 145, (2004), pp. 2623–2627.

    PubMed  Google Scholar 

  3. C. S. Fuchs, M. J. Stampfer, G.A. Colditz, E.L. Giovannucci, J.E. Manson, I. Kawachi, D.J. Hunter, S.E. Hankinson, C.H. Hennekens and B. Rosner: “Alcohol consumption and mortality among women”, New Engl. J. Med., Vol. 332, (1995), pp. 1245–1250.

    PubMed  Article  CAS  Google Scholar 

  4. J. M. Gaziano, J.E. Buring, J. L. Breslow, S.Z. Goldhaber, B. Rosner, M. VanDenburgh, W. Willett, C.H. Hennekens.: “Moderate alcohol intake increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction”, New Engl. J. Med., Vol. 329, (1993), pp. 1829–1834.

    PubMed  Article  CAS  Google Scholar 

  5. R. Doll, R. Peto, E. Hall, K. Wheatley, R. Gray.: “Mortality in relation to consumption of alcohol: 13 years’ observations on male British doctors”, Brit. Med. J., Vol. 309, (1994), pp. 911–918.

    PubMed  CAS  Google Scholar 

  6. C.L. Hart, G. D. Smith, D. J. Hole, V. M. Hawthorne: “Alcohol consumption and mortality from all causes, coronary heart disease, and stroke: results from a prospective cohort study of Scottsh men with 21 years of follow up”, Brit. Med. J., Vol. 318, (1999), pp. 1725–1729.

    PubMed  CAS  Google Scholar 

  7. R. D. Langer, M. H. Criqui, D. M. Reed: “Lipoproteins and blood pressure as biological pathways for effect of moderate alcohol consumption on coronary heart disease”, Circulation, Vol. 85, (1992), pp. 910–915.

    PubMed  CAS  Google Scholar 

  8. J.M. Leppälä, M. Paunio, J. Virtamo, R. Fogelholm, D. Albanes, P.R. Taylor, O.P. Heinonen: “Alcohol consumption and stroke incidence in male smokers”, Circulation, Vol. 100, (1999), pp. 1209–1214.

    PubMed  Google Scholar 

  9. M.J. Stampfer, G.A. Colditz, W.C. Willett, F.E. Speizer, C.H. Hennekens: “A propective study of moderate alcohol consumption and the risk of coronary disease and stroke in women”, New Engl. J. Med., Vol. 319, (1988), pp. 267–273.

    PubMed  CAS  Article  Google Scholar 

  10. L. Szollár: The wine (Hung). Táplálkozás-Anyagcsere-Diéta, Vol.1, (1995), pp. 37–42.

    Google Scholar 

  11. Magyar Gyógyszerkönyv (Hungarian Pharmacopeia) I. Pesti Könyvnyomda Rt. Budapest, (1871), pp. 465–473.

  12. A.S.St. Leger, A.L. Cochrane, F. Moore: “Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine”, Lancet, Vol. 1, (1979), pp. 1017–1020.

    Article  Google Scholar 

  13. M. Law, N. Wald: “Why heart disease mortality is low in France: the time lag explanation”, Brit. Med. J., Vol.318, (1999), pp. 1471–1476.

    PubMed  CAS  Google Scholar 

  14. M.J. Stampfer, J. H. Kang, J. Chen, R. Cherry, F. Grodstein: “Effects of moderate alcohol consumption on cognitive function in women”, N Engl J Med, Vol. 352, (2005), pp. 245–253.

    PubMed  Article  CAS  Google Scholar 

  15. M. H. Criqui, B. A. Golomb: “Should patients with diabetes drink to to their health?”, JAMA, Vol. 282, (1999), pp. 279–280.

    PubMed  Article  CAS  Google Scholar 

  16. S.S. Hall: “Longevity research. In vino vitalis? Compounds activate life-extending genes”, Science, Vol. 30. (2003), pp. 1165.

    Article  Google Scholar 

  17. M. Marmot, E. Brunner: “Alcohol and cardiovasc disease: the status of th U shaped curve”, Brit. Med. J., Vol. 303, (1991), pp. 565–568.

    PubMed  CAS  Article  Google Scholar 

  18. T.J. Regan: “Moderate alcohol consumption and risk of coronary heart disease among women with type 2 diabetes mellitus”, Circulation, Vol. 102, (2000), pp. 487–488.

    PubMed  CAS  Google Scholar 

  19. P. McElduff, A.J. Dobson: “How much alcohol and how often? Population based case-control study of alcohol consumption and risk of a major coronary event”, Brit. Med. J., Vol. 314, (1997), pp. 1159–1154.

    PubMed  CAS  Google Scholar 

  20. K. J. Mukamal, W.T. Longstreth, M.A. Mittleman R.M. Crum, D.S. Siscovick: “Alcohol consumption and subclinical findings on magnetic resonance imaging the brain in older adults: the cardiovascular health study”, Stroke, Vol. 32, (2001), pp. 1939–1946.

    PubMed  CAS  Google Scholar 

  21. S.W. Nigdikar, N. R. Williams, B. A. Griffin, A. N. Howard: “Consumption of red wine polyphenols reduces the susceptibility of low-density lipoproteins to oxidation in vivo”, Am. J. Clin. Nutr., Vol. 68. (1998), pp. 258–265.

    PubMed  CAS  Google Scholar 

  22. R. L. Sacco, M. Elkind, B. Boden-Albala, I. F. Lin, D. E. Kargman, W. A. Hauser, S. Shea, M.C. Paik: “The protective effect of moderate alcohol consumption on ischemic stroke”, JAMA, Vol. 281. (1999), pp. 53–60.

    PubMed  Article  CAS  Google Scholar 

  23. C. G. Solomon, F. B. Hu, M. J. Stampfer, G. A. Colditz, F. E. Speizer, E. B. Rimm, W. C. Willett, J.E. Manson: “Moderate alcohol consumption and risk of coronary heart disease among women with type 2 diabetes mellitus”, Circulation, Vol. 102. (2000), pp. 494–499.

    PubMed  CAS  Google Scholar 

  24. M. J. Stampfer, G. A. Colditz, W. C. Willett, J. E. Manson, R. A. Arky, C. H. Hennekens, F. E. Speizer: “A prospective study of moderate alcohol drinking and risk of diabetes in women”, Am J Epidemiol., Vol. 128, (1988), pp. 549–558.

    PubMed  CAS  Google Scholar 

  25. R.D. Langer, M.H. Criqui, D.M. Reed: “Lipoproteins and blood pressure as biological pathways for effect of moderate alcohol consumption on coronary heart disease”, Circulation, Vol. 85. (1992), pp. 910–915.

    PubMed  CAS  Google Scholar 

  26. A. A. Lorimier: “Alcohol, wine, and health”, Am. J. Surg., Vol. 180. (2000), pp. 357–361

    PubMed  Article  Google Scholar 

  27. A. Lugasi, A. Blázsovics, E. Dworschák, J. Fehér: “The cardioprotective effects of red wines according to the literature (Hung.)”, Orv. Hetil., Vol. 138. (1997), pp. 673–678

    PubMed  CAS  Google Scholar 

  28. E.B. Rimm, A. Klatsky, D. Grobbee, M.J Stampfer: “Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits?”, Brit. Med. J., Vol. 312. (1996), pp. 731–736.

    PubMed  CAS  Google Scholar 

  29. M. M. Thun, R. Peto, A. D. Lopez, J. H. Monaco, S. J. Henley, C. W. Jr. Heath, R.. Doll: “Alcohol consumption and mortality among middle-aged and elderly U.S. adults”, New Engl. J. Med., Vol. 337. (1997), pp. 1705–1714.

    PubMed  Article  CAS  Google Scholar 

  30. M. Trevisan, E. Schisterman, A. Mennotti, G. Farchi, S. Conti: “Drinkind pattern and mortality: the Italian Risk Factor and Life Expectancy pooling project”, Ann. Epidemiol., Vol. 11, (2001), pp. 312–319.

    PubMed  Article  CAS  Google Scholar 

  31. C. T. Valmadrid, R. Klein, S. E. Moss, B. E. Klein, K. J. Cruickshanks: “Alcohol intake and the risk of coronary heart disease mortality in persons with older-onset diabetes mellitus”, JAMA, Vol. 282. (1999), pp. 239–246.

    PubMed  Article  CAS  Google Scholar 

  32. M. H. Criqui, B. L. Ringel: “Does diet alcohol explain the French paradox?”, Lancet, Vol. 344, (1994), pp. 1719–1723.

    PubMed  Article  CAS  Google Scholar 

  33. A, Lugasi, A. Blazovics, J. Feher: “In vitro findings of antioxidant properties of Hungarian red wines (Hungarian)”, Orv Hetil., Vol. 140, (1999), 2051–2056.

    PubMed  CAS  Google Scholar 

  34. S. Renaud, M. de Lorgeril: “Wine, alcohol, platelets, and French paradox for coronary heart disease”, Lancet, Vol. 339, (1992), pp. 1523–1526.

    PubMed  Article  CAS  Google Scholar 

  35. J. Belleville: “The French paradox: possible involvement of ethanol in the protective effect against cardiovascular diseases”, Nutrition, Vol. 18, (2002), pp. 173–177.

    PubMed  Article  CAS  Google Scholar 

  36. L. Szollár: “Pathophysiology of Metabolism”, In: Kórélettan (Pathophysiology), Ed.: L. Szollár, Semmelweis Publishing House, Budapest, 1993. pp. 156–224.

    Google Scholar 

  37. A. A. Lorimier: “Alcohol, wine, and health”, Am. J. Surg., Vol. 180, (2000), pp. 357–361.

    PubMed  Article  Google Scholar 

  38. A. M. Malarcher, W. H. Giles, J. B. Croft, M. A.Wozniak, R. J. Wityk, P. D. Stolley, B. J. Stern, M. A. Sloan, R. Sherwin, T. R. Price, R. F. Macko, C. J. Johnson, C. J. Earley, D. W. Buchholz, S. J. Kittner: “Alcohol intake, type of beverage, and the risk of cerebral infarction in young women”, Stroke, Vol. 32 (2001), pp. 77–83.

    PubMed  CAS  Google Scholar 

  39. J. Vina, C. Borras, J. Gambini, J. Sastre, F. V. Pallardo: “Why females live longer than males: control of longevity by sex hormones”, Sci Aging Knowledge Environ., Vol. 23, (2005), pp. 2005–2022.

    Google Scholar 

  40. A. P. Whelan, W. H. Sutherland, M. P. McCormick, D. J. Yeoman, S. A. de Jong, M. J. Williams: “Effects of white and red wine on endothelial function in subjects with coronary artery disease”, Intern Med J., Vol. 34, (2004), pp. 224–228.

    PubMed  Article  CAS  Google Scholar 

  41. E. B. Rimm, J. Chan, M. J. Stampfer: “Prospective study of cigarette smoking, alcohol use, and the risk of diabetes in men”, Brit. Med. J., Vol. 310, (1995), pp. 555–559.

    PubMed  CAS  Google Scholar 

  42. M. de Lorgeril, P. Salen, F. Boucher, J. de Leiris, F. Paillard: “Effect of wine ethanol on serum iron and ferritin levels in patients with coronary heart disease”, Nutr. Metab.Cardiovasc. Dis., Vol. 11. (2001), pp. 176–180.

    PubMed  Google Scholar 

  43. Y. Miyagi, K. Miwa, H, Inoue: “Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice”, Am J Cardiol., Vol. 80. (1997), pp. 1627–1631

    PubMed  Article  CAS  Google Scholar 

  44. E. N. Frankel, A. L. Waterhouse, J. E. Kinsella: “Inhibition of human LDL oxidation by resveratrol”, Lancet, Vol. 341. (1993), pp. 1103–1104.

    PubMed  Article  CAS  Google Scholar 

  45. S. Maxwell, A. Cruickshank, G. Thorpe: “Red wine and antioxidant activity in serum”, Lancet, Vol. 344, (1994), pp. 193–194.

    PubMed  Article  CAS  Google Scholar 

  46. A. Par, E. Roth, Gy. Rumi, Z. Kovacs, J. Nemes, G. Mozsik: “Oxidative stress and antioxidant protection in alcoholic liver disease and in chronic hepatitis C (Hung.)”, Orvosi Hetilap, Vol. 144. (2000), pp. 1655–1660

    Google Scholar 

  47. S. C. Renaud, J-C. Ruf: “Effects of alcohol on platelet functions”, Clin. Chim. Acta, Vol. 246, (1996), pp. 77–89.

    PubMed  Article  CAS  Google Scholar 

  48. A. Blázovics, E. Fehér, J Fehér: “Role of free radical reactions in experimental hyperlipidemia in the pathomechanism of fatty liver”, In Free radicals and liver ed. Csomós, G., Fehér, J.: Springer Verlag, Berlin, 1992, pp. 96–123.

    Google Scholar 

  49. K. Hagymasi, A. Blazovics, J. Feher, A. Lugasi, S. T. Kristo, A Kery: “The in vitro effect of dandelions antioxidants on microsomal lipid peroxidation”, Phytother Res., Vol. 14, (2000), pp. 43–44.

    PubMed  Article  CAS  Google Scholar 

  50. C. A. Camargo, P. T. Jr., Williams, K. M. Vranizan, J. J. Albers, P. D. Wood: “The effect of moderate alcohol intake on serum apolipoprotein A-I and A-II”, JAMA, Vol. 253, (1985), pp. 2854–2857.

    PubMed  Article  Google Scholar 

  51. K. Hagymasi, A. Blazovics, G. Lengyel, I. Kocsis, J. Feher: “Oxidative damage in alcoholic liver disease”, Eur J Gastroenterol Hepatol., Vol. 13. (2001), pp. 49–53.

    PubMed  Article  CAS  Google Scholar 

  52. A. Lugasi: “Potencial health protective effects of food flavonoids (Hung.)”, Orvosi Hetilap, Vol. 241, (2000), pp. 1751–1760.

    Google Scholar 

  53. S. Renaud, D. Lanzmann-Petithory: “Coronary heart disease: dietary links and pathogenesis”, Publ. Health Nutr., Vol. 4, (2001), pp. 459–474.

    CAS  Google Scholar 

  54. J. Fehér, D. Drexler: “Polyphenols in wine (Hung.)”, Borbar?at (Friends of Wine), Vol. 6, (2001), pp. 56–58.

    Google Scholar 

  55. A. Lugasi, A. Blázovics, E. Dworschak J. Fehér: “Cardio-protective effect of red wine as reflected in the literature (Hungarian)”, Orv Hetil., Vol. 138, (1997), pp. 673–678.

    PubMed  CAS  Google Scholar 

  56. T. Nakayama: “Suppression of hydroperoxide-induced cytotoxicity by polyphenols”, Cancer Res., Vol. 54, (1994), pp. 1191–1193S.

    Google Scholar 

  57. C. R. Pace-Asciak, S. Hahn, E. P. Diamandis, G. Soleas, D. M. Goldberg: “The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease”, Clin. Chim. Acta, Vol. 235, (1995) pp. 207–219

    PubMed  Article  CAS  Google Scholar 

  58. L. H. Opie, S. Lecour: “The red wine hypothesis: from concepts to protective signalling molecules”, European. Heart Journal, Vol. 28, (2007), pp. 1683–1693

    PubMed  Article  CAS  Google Scholar 

  59. S. Das, A. Tosaki, D. Bagchi, N. Maulik, D. K. Das: “Resveratrol-mediated activation of cAMP response element-binding protein through adenosine A3 receptor by Aktdependent and-independent pathways”, J Pharmacol Exp Ther, Vol. 314, (2005), pp. 762–769.

    PubMed  Article  CAS  Google Scholar 

  60. U. G. Haider, T. U. Roos, M. I. Kontaridis, B. G. Neel, D. Sorescu, K. K. Griendling, A. M. Vollmar, V. M. Dirsch: “Resveratrol inhibits angiotensin II-and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2”, Mol Pharmacol, Vol. 68, (2005), pp. 41–48.

    PubMed  CAS  Google Scholar 

  61. G. Stef, A. Csiszar, K. Lerea, Z. Ungvari, G. Veress: “Resveratrol inhibits aggregation of platelets from high-risk cardiac patients with aspirin resistance”, J Cardiovasc Pharmacol, Vol. 48, (2006), pp. 1–5.

    PubMed  Article  CAS  Google Scholar 

  62. A. Csiszar, K. Smith, N. Labinskyy, Z. Orosz, A. Rivera, Z. Ungvari: “Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition”, Am J Physiol Heart Circ Physiol, Vol. 291, (2006), pp. H1694–H1699.

    PubMed  Article  CAS  Google Scholar 

  63. T.L. Zern and M.L. Fernandez: “Cardioprotective Effects of Dietary Polyphenols”, J. Nutr. Vol., Vol. 135, (2005), pp. 2291–2294.

    CAS  Google Scholar 

  64. O.H. Franco, L. Bonneux, C. de Laet, A. Peeters, E. W. Steyerberg and J.P. Mackenbach: “The Polymeal: a more natural, safer, and probably tastier (than the Polypill) strategy to reduce cardiovascular disease by more than 75%”, Brit. Med. J. Vol., Vol. 329, (2004), pp. 1447–1450.

    Article  Google Scholar 

  65. J. Feher and A. Lugasi: “Antioxidant characteristics of a newly developed vermouth wine? (Hung.)”, Orv Hetil., Vol. 145, (2004), pp. 2623–2627.

    PubMed  Google Scholar 

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Fehér, J., Lengyel, G. & Lugasi, A. The cultural history of wine - theoretical background to wine therapy. cent.eur.j.med 2, 379–391 (2007). https://doi.org/10.2478/s11536-007-0048-9

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Keywords

  • wine
  • polyphenol
  • French paradox
  • oxidative stress
  • wellness