Skip to main content
SpringerLink
Log in

The relationship between features of metabolic syndrome and blood adipocytokine concentrations in the morbid obese patients during dynamic weight loss

  • Research Article
  • Published:
Central European Journal of Medicine

Abstract

Bariatric surgery is the most effective method to achieve weight loss in obese subjects.

The aim of this study was to evaluate some adipocytokines and insulin, as well as parameters of metabolic syndrome of the obese patients, for three and six months after vertical banded gastroplasty, in the time of dynamic weight loss.

Seven males and two females aged 28 to 49 years, with long lasting simple obesity and the presence of metabolic syndrome, were studied. After surgical treatment the values of the body mass index, waist circumference, systolic and diastolic blood pressure, total cholesterol, LDL cholesterol, triglycerides, and blood concentrations of leptin decreased significantly.

Before surgical operation of all obese patients no statistically significant correlations between studied parameters were noted. Three and six months later a lot of correlations between studied parameters appeared.

In conclusion, (a) vertical-banded gastroplasty is a valuable method in treatment of obese subjects, leading to a significant decrease in body weight and improvement in some parameters of metabolic syndrome in a few months after surgery, (b) adipocytokines, together with an unknown gastric factor, may be key factors in the control of some features of the metabolic syndrome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. D.E. Cummings and M.W. Schwartz: “Genetics and pathophysiology of human obesity”, Ann. Rev. Med., Vol. 54, (2003), pp. 453–471.

    Article  PubMed  CAS  Google Scholar 

  2. B.E. Wisse and M.W. Schwartz: “The skinny of neurotrophins”, Nature Neurosci., Vol. 6, (2003), pp. 655–656.

    Article  PubMed  CAS  Google Scholar 

  3. S.M. Grundy: “Obesity, metabolic syndrome, and cardiovascular disease”, J. Clin. Endocrinol. Metabol., Vol. 89, (2004), pp. 2595–2600.

    Article  CAS  Google Scholar 

  4. C.C. Carr and J.D. Brunzell: “Abdominal obesity and dyslipidemia in the metabolic syndrome: Importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk”, J. Clin. Endocrinol. Metabol., Vol. 89, (2004), pp. 2601–2607.

    Article  CAS  Google Scholar 

  5. M. Lafontan and M. Berlan: “Do regional differences in adipocyte biology provide new pathopysiological insights?”, Trends Pharmacol. Sci., Vol. 24, (2003), pp. 276–283.

    Article  PubMed  CAS  Google Scholar 

  6. K.G. Alberti and P.Z. Zimmet: “Definition, diagnosis and classification of diabetes mellitus and its complications. I. Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation, Diabetes Med., Vol. 15, (1998), pp. 539–553.

    Article  CAS  Google Scholar 

  7. National Cholesterol Educational Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report on the National Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)”, JAMA, Vol. 285 (2001), pp. 2486–2497.

    Article  Google Scholar 

  8. W. Fujimoto, S. Abbate, S. Kahn, J. Hokanson and J. Brunzell: “The visceral adiposity syndrome in Japanese-American men”, Obes. Res., Vol. 2, (1994), pp. 364–371.

    PubMed  CAS  Google Scholar 

  9. N. Ruderman, D. Chisholm, X. Pi-Sunyer and S. Schneider: “The metabolically obese, normal-weight individuals revisited”, Diabetes, Vol. 47, (1998), pp. 699–713.

    PubMed  CAS  Google Scholar 

  10. N. Barzilai, L. She, B.Q. Liu, P. Vuguin, P. Cohen, J. Wang and L. Rosetti,:, “Surgical removal of visceral fat reverses hepatic insulin resistance”, Diabetes, Vol. 48, (1999), pp. 94–98.

    PubMed  CAS  Google Scholar 

  11. J. Harvey and M.L.J. Ashford: “Leptin in CNS: Much for than a satiety signal”, Neuropharmacology, Vol. 44, (2003), pp. 845–854.

    Article  PubMed  CAS  Google Scholar 

  12. J. Komorowski, J. Jankiewicz-Wika and H. Stępień: “Effects of Gn-RH, TRH, and CRF administration on plasma leptin levels ln lean and obese women”, Neuropeptides, Vol. 34, (2000), pp. 89–97.

    Article  PubMed  CAS  Google Scholar 

  13. S. Ten and N. MacLaren: “Insulin resistance in children”, J. Clin. Endocrinol. Metabol., Vol. 89, (2004), pp. 2526–2539.

    Article  CAS  Google Scholar 

  14. G.K. Shetty, P.A. Economides, E.S. Horton, Ch.S. Mantzoros and A. Veves: “Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes”, Diabetes Care, Vol. 27, (2004), pp. 2450–2457.

    PubMed  CAS  Google Scholar 

  15. Y. Arita, S. Kihara, N. Ouchi, M. Takahashi, K. Maeda, J. Miyagawa, K. Hotta, I. Shimomura, T. Nakamura, K. Miyaoka, H. Kuriyama, M. Nishida, S. Yamashita, K. Okubo, K. Matsubara, M. Muraguchi, Y. Ohmoto, T. Funahashi and Y. Matsuzawa: “Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity”, Biochem. Biophys. Res. Commun., Vol. 257, (1999), pp. 79–83.

    Article  PubMed  CAS  Google Scholar 

  16. Y. Yamamoto, Y. Hirose, I. Saito, M. Tomita, M. Taniyama, K. Matsubara, Y. Okazaki, T. Ishi, K. Nishikai and T. Saruta: “Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-choesterol, independent of body mass index, in the Japanese population”, Clin. Sci. (Lond.), Vol. 103, (2002), pp. 132–147.

    Google Scholar 

  17. M. Matsubara, S. Maruka and S. Katayose: “Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women”, Eur. J. Endocrinol., Vol. 147, (2002), pp. 173–180.

    Article  PubMed  CAS  Google Scholar 

  18. C.M. Steppan, S.T. Bailey, S. Bhat, E.J. Brown, R.R. Banerjee, C.M. Wright, H.M. Patel, R.S. Ahima and M.A. Lazar: “The hormone resistin links obesity to diabetes”, Nature, Vol. 409, (2001), pp. 307–312.

    Article  PubMed  CAS  Google Scholar 

  19. C.M. Steppan and M.A. Lazar: “Resistin and obesity-associated insulin resistance”, Trends Endocrinol. Metab., Vol. 13, (2002), pp. 18–23.

    Article  PubMed  CAS  Google Scholar 

  20. R. Ohmori, Y. Momiyama, R. Kato, H. Toniguchi, M. Ogura, M. Ayori, H. Nakamura and F. Ohsuzu: “Associations between serum resistin levels and insulin resistance, inflammation, and coronary artery disease”, J. Am. Coll. Cardiol., Vol. 45, (2005), pp. 379–380.

    Article  Google Scholar 

  21. R.E. Brolin: “Bariatric surgery and long-term control of morbid obesity”, JAMA, Vol. 288, (2002), pp. 2793–2796.

    Article  PubMed  Google Scholar 

  22. E.C. Mun, G.L Blackburn and J.B. Matthews: “Current status of medical and surgical therapy for obesity”, Gastroenterology, Vol. 120, (2001), pp. 669–681.

    Article  PubMed  CAS  Google Scholar 

  23. D.E. Cummings, J. Overduin and K.E. Foster-Schubert: “Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution”, J. Clin. Endocrinol. Metabol, Vol. 89, (2002), pp. 2608–2615.

    Article  Google Scholar 

  24. G.A. Bray and L.A. Tartaglia: “Medicinal strategies in the treatment of obesity”, Nature, Vol. 404, (2000), pp. 672–677.

    PubMed  CAS  Google Scholar 

  25. K.M. Mc Tigue, R. Harris, B. Hemphill, L. Lux, S. Sutton, A.J. Bunton and K.N. Lohr: “Screening and interventions for obesity in adults: summary of the evidence for the US Prevention Task Force”, Ann. Intern. Med., Vol. 139, (2003), pp. 933–949.

    Google Scholar 

  26. W.J. Pories, M.S. Swanson, K.G. Mac Donald, S.B. Long, P.G. Morris, B.M. Brown, H.A. Barakat, R.A. de Ramon, D. Israel and J.M. Dolezal: “Who would have thought it? An operation proves to be the most effective therapy for adult onset diabetes mellitus”, Ann. Surg., Vol. 222, (1995), pp. 339–352.

    PubMed  CAS  Google Scholar 

  27. L. Sjostrom, A-K. Lindroos, M. Peltonen, J. Torgrson, C. Bouchard, B. Carlsoon, S. Dahlgren, B. Larsen, K. Narbro, C.D. Siostrom, M. Sullivan and H. Wedel: “Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery”. N. Engl. J. Med., Vol. 351, (2004), pp. 2683–2693.

    Article  PubMed  Google Scholar 

  28. H. Buchwald, Y. Avidor, E. Braunwald, M.D. Jensen, W. Pories, K. Fahrbach and K. Schoelles: “Bariatric surgery”, JAMA, Vol. 292, (2004), pp. 1724–1737.

    Article  PubMed  CAS  Google Scholar 

  29. N. Kubota, Y. Terauchi, T. Yamauchi, T. Kubota, M. Moroi, J. Matsui, K. Eto, T. Yamashita, J. Kamon, H. Satoh, W. Yano, P. Frogeul, R. Nagai, S. Kimura, T. Kadowaki and T. Noda: “Disruption of adiponectin causes insulin resistance and neointimal formation”, J. Biol. Chem., Vol. 277, (2002), pp. 25863–25866.

    Article  PubMed  CAS  Google Scholar 

  30. T. Yamauchi, J. Kamon, H. Waki, Y. Terauchi, N. Kubota, K. Hara, Y. Mori, T. Ide, K. Murakami, N. Tsuboyama-Kasaoka, O. Ezaki, Y. Akanuma, O. Gavrilova, C. Vinson, M.L. Reitman, K. Kagechika, Y. Shudo, M. Yoda, Y. Nakano, K. Tobe, R. Nagai, S. Kimura, M. Tomita, P. Froguel and T. Kadowaki: “The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity”, Nat. Med, Vol. 7, (2001), pp. 941–946.

    Article  PubMed  CAS  Google Scholar 

  31. M. Blucher, M.D. Michael, O.D. Peroni, K. Ueki, N. Carter, B.B. Kahn and C.R. Kahn: “Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance”, Dev. Cell., Vol. 3, (2002), pp. 25–38.

    Article  Google Scholar 

  32. N. Stefan, B. Vozarova, T. Funahashi, Y. Matsuzawa, C. Weyer, S. Lindsay, J.F. Yongren, P.J. Havel, R.E. Pratley, C. Bogardus and P.A. Tataranni: “Plasma adiponectin concentrations in association with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans”, Diabetes, Vol. 51, (2002), pp. 1884–1888.

    PubMed  CAS  Google Scholar 

  33. R.S. Lindsay, T. Funahashi, L.R. Hanson, Y. Matsuzawa, S. Tanaka, P.A. Tataranni, W.C. Knowler and J. Krakoff: “Adiponectin and development of type 2 diabetes in the Pima Indian population”, Lancet, Vol. 360, (2002), pp. 57–58.

    Article  PubMed  CAS  Google Scholar 

  34. T. Yokota, K. Oritani, I. Takahashi, J. Ishikawa, A. Matsuyama, N. Ouchi, S. Kichara, T. Funahashi, A.J. Tenner, Y. Tomiyama and Y. Matsuzawa: “Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages”, Blood, Vol. 96, (2000), pp. 1723–1732.

    PubMed  CAS  Google Scholar 

  35. N. Ouchi, S. Kichara, Y. Arilsa, K. Maeda, H. Kuriyama, Y. Okamoto, K. Hotta, M. Nishida, M. Takahashi, T. Nakamura, S. Yamashita, T. Funahashi and Y. Matsuzawa: “Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin”, Circulation, Vol. 100, (1999), pp. 2473–2476.

    PubMed  CAS  Google Scholar 

  36. N. Ouchi, S. Kihara, Y. Ariata, M. Nishida, A. Matsuyama and Y Okamoto: “Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages”, Circulation, Vol. 103, (2001), pp. 1057–1063.

    PubMed  CAS  Google Scholar 

  37. M. Matsubara, S. Maruka and S. Katayose: “Inverse relationship between plasma adiponectin and leptin concentrations in normal weight and obese women. Eur. J. Endocrinol., Vol. 147, (2002), pp. 173–180.

    Article  PubMed  CAS  Google Scholar 

  38. C. Weyer, T. Funahashi, S. Tanaka, K. Hotta, Y. Matsuzawa, R.E. Pratley and P.A. Tataranni: “Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia”, J. Clin. Endocrinol. Metabol., Vol. 86, (2001), pp. 1930–1935.

    Article  CAS  Google Scholar 

  39. J.G. Yu, A.L. Javorschi Havener, Y.T. Kruszynska, R.A. Norman, M. Sinha and J.M. Olefsky: “The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetes subjects”, Diabetes, Vol. 51, (2002), pp. 2968–2974.

    PubMed  CAS  Google Scholar 

  40. N. Satoh, Y. Ogawa, T. Usui, T. Tagami, S. Kono, H. Uesugi, H. Sugiyama, A. Sugawara, K. Yamada, A. Shimatsu, H. Kuzuya and K. Nakao: “Antiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effect”, Diabetes Care, Vol. 26, (2003), pp. 2493–2499.

    PubMed  CAS  Google Scholar 

  41. I.A. Harsch, C. Koebnick, H. Wallaschofski, S.P. Schahin, E.G. Hahn, J.H. Ficker, T. Lohmann and P.C. Konturek: “Resistin levels in patients with obstructive sleep apnea syndrome-the link to subclinical inflammation?”, Med. Sci. Monitor, Vol. 10, (2004), pp. CR510–515.

    CAS  Google Scholar 

  42. N. Siswal, A.K Singh, B. Aruna, S. Mukhopadhyay, S. Ghosh and N.Z. Ehtesham: “Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway”, Biochem. Biophys. Res. Commun., Vol. 334, (2005), pp. 1092–1101.

    Article  Google Scholar 

  43. G.H. Ballantyne, A. Gumbs and I.M. Modlin: “Changes in insulin resistance following bariatric surgery and the adipoinsular axis: role of the adipocytokines, leptin, adiponectin and resistin”, Obes Surg, Vol. 15, (2005), pp. 692–699.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Endocrinology, Medical University of Łódź, 91-425 cŁódź, Poland

    Joanna Jankiewicz-Wika, Henryk Stępień & Jan Komorowski

  2. Department of General Surgery, Ministry of the Interior Hospital, 91-425, Łódź, Poland

    Krzysztof Kołomecki & Jacek Cywiński

  3. Department of Cardiology, Medical University of Łódź, 91-425, Łódź, Poland

    Katarzyna Piestrzeniewicz

Authors
  1. Joanna Jankiewicz-Wika
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Krzysztof Kołomecki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jacek Cywiński
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Katarzyna Piestrzeniewicz
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Henryk Stępień
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jan Komorowski
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Jankiewicz-Wika, J., Kołomecki, K., Cywiński, J. et al. The relationship between features of metabolic syndrome and blood adipocytokine concentrations in the morbid obese patients during dynamic weight loss. cent.eur.j.med 1, 136–147 (2006). https://doi.org/10.2478/s11536-006-0015-x

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.2478/s11536-006-0015-x

Keywords

Search

Navigation