Central European Journal of Medicine

, Volume 1, Issue 1, pp 99–102 | Cite as

Unusual case of double acute intoxication with tamoxifen complicated by miscarriage

  • Jacek Sein Anand
  • Zygmunt Chodorowski
  • Roman P. Korolkiewicz
  • Dorota Klimaszyk
  • Magdalena Łukasik-Głębocka
Case Report


Background: A 24-year-old female had attempted suicide twice, at the age of 20 and 24, using tamoxifen.

Case report: Subsequent to the first acute intoxication a development of bilateral ovarian cysts was observed. Cysts regressed spontaneously within 8 weeks. Five weeks after the second suicidal attempt, pregnant patient (15 weeks of gestation) was admitted to the hospital with vaginal bleeding and suspicion of miscarriage. The autopsy of the fetus did not reveal any gross abnormalities, whereas the microscopic examination demonstrated numerous foci of necrosis in the placental decidua. Other fetal membranes as well as the umbilical cord were normal.

  1. 1.

    Acute intoxication with tamoxifen may be connected with the formation of follicular ovarian cysts.

  2. 2.

    During pregnancy, intoxication with tamoxifen, may result in delayed miscarriage.



Tamoxifen acute intoxication pregnancy miscarriage 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    Q. Cai, M. Bensen, R. Greene and J. Kirchner: “Tamoxifen-induced transient multifocal hepatic fatty in.ltration”, Am. J. Gastroenterol., Vol. 95, (2000), pp. 277–279.PubMedCrossRefGoogle Scholar
  2. [2]
    A. Shushan, T. Peretz, B. Uziely et al.: “Ovarian cyst in premenopausal and postmenopausal tamoxifen — treated women with breast cancer”, Am. J. Obstet. Gynecol., Vol. 174, (1996), pp. 141–144.PubMedCrossRefGoogle Scholar
  3. [3]
    I. Cohen, A. Figer, R. Tepper et al.: “Ovarian overstimulation and cystic formation in premenopausal tamoxifen exposure: comparison between tamoxifen — treated and nontreated breast cancer patients”, Gynecol. Oncol., Vol. 72, (1999), pp. 202–207.PubMedCrossRefGoogle Scholar
  4. [4]
    M. Kazandi, F. Sendag and F. Akercan: “Ovarian cyst in postmenopausal tamoxifen — treated breast cancer patients with endometrial thickening detected by transvaginal sonography”, Eur. J. Gynecol. Oncol., Vol. 23, (2002), pp. 257–260.Google Scholar
  5. [5]
    S. Terada, K. Uchide, N. Suzuki and K.A. Akasofu: “Follicular cyst during tamoxifen therapy in a premenopausal breast cancer woman”, Gynecol. Obstet. Invest., Vol. 35, (1993), pp. 62–64.PubMedCrossRefGoogle Scholar
  6. [6]
    H. Changhai, G. Youlun, Y. Jie et al.: “A randomized comparative study on mifeproston alone and in combination with tamoxifen for emergency contraception”, Contraception, Vol. 66, (2002), pp. 221–224.PubMedCrossRefGoogle Scholar
  7. [7]
    S. Christine-Maitre, P. Bouchard and I.M. Spitz: “Medical termination of pregnancy”, N. Engl. J. Med., Vol. 342, (2000), pp. 946–956.CrossRefGoogle Scholar

Copyright information

© Central European Science Journals Warsaw and Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Jacek Sein Anand
    • 1
  • Zygmunt Chodorowski
    • 1
  • Roman P. Korolkiewicz
    • 2
  • Dorota Klimaszyk
    • 3
    • 4
  • Magdalena Łukasik-Głębocka
    • 3
  1. 1.Clinic of Internal Medicine and Acute PoisoningsMedical UniversityGdańskPoland
  2. 2.Department of PharmacologyMedical UniversityGdańskPoland
  3. 3.Department of Toxicology and Internal DiseasesF. Raszeja HospitalPoznańPoland
  4. 4.Department of Emergency Medicine and Disaster MedicineUniversity of Medical SciencesPoznańPoland

Personalised recommendations