Abstract
The therapy of radioresistant tumors remains an urgent problem in medicine. To solve this problem neutron capture therapy (NCT) and photon activation therapy (PAT) are used. The essential feature of this such technique is the uptake of tumor chemical elements, which interact with thermal neutrons (NCT) and X-rays (PAT). The aims of the investigation were to study a biodistribution of the complexes of hyaluronic acid with boron (3 mg B mL−1) and gold (20 mg Au mL−1) in mice with melanoma B-16 after intratumoral administration. An optimal time for NCT was 30 minutes after administration when boron concentration in the tumor was more than 30 μg g−1 and exceeded boron content in surrounding tissues. The maximal gold content in tumor (180–260 mg g−1) was obtained in 30 minutes after the preparation introduction. The highest ratios of gold in tumor and surrounding tissues (a necessary condition for forming of the local absorbed dose in tumor) was obtained in 0.5 and 1 h. On the basis of the data obtained, it is possible to assume the perspectives of the non-toxic boron compounds for use in NCT and the gold compounds for use primarily as contrast agents for diagnostic purposes.
Similar content being viewed by others
References
Sweet W.H., Early history of development of boron neutron capture therapy of tumors, J. Neuro- Oncology., 1997, 1-2, 19–26
Barth R.F., Soloway A.H., Brugger R.M., Boron neutron capture therapy of brain tumors: past history, current status, and future potential, Cancer Invest., 1996, 6, 534–550
Soloway A.H., Tjarks W., Barnum B.A., Rong F.G., Barth R.F., Codogni I.M. et al, The chemistry of neutron capture therapy, Chem. Rev., 1998, 4, 1515–1562
Koryakin S. N., Compounds for neutron capture therapy and their distribution in tumors and surrounding tissues of animals (a review), Pharmaceutical Chemistry Journal, 2006, 11, 583–587
Matsudaira H., Ueno A.M., Furuno I., Iodine contrast medium sensitizes cultured mammalian cells to x-rays but not to γ rays, Radiat. Res., 1980, 84, 144–148
Kobayashi K., Usami N., Porcel E., Lacombe S., Le Sech C., Enhancement of radiation effect by heavy elements, Mutation. Res., 2010, 704, 123–131
Choi G.H., Seo S.J., Kim K.H., Kim H.T., Park S.H., Lim J.H., Kim J.K., Photon activated therapy (PAT) using monochromatic synchrotron X-rays and iron oxide nanoparticles in a mouse tumor model: feasibility study of PAT for the treatment of superficial malignancy, Radiation Oncology, 2012, 184, 1–10
Hainfeld J.J., Slatkin D.N., Smilowitz H.M., The use of gold nanoparticles to enhance radiotherapy in mice, Phys. Med. Biol., 2004, 18, 309–315
Rahman W.N., Ackerly T., He C.F., Jackson P., Wong C., Davidson R. et al., Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy, Nanomedicine, 2009, 5, 136–142
Duncan R., The dawning era of polymer therapeutics, Nat. Rev. Drug Discov., 2003, 2, 347–360
Farokhzad O.C., Langer R., Nanomedicine: developing smarter therapeutic and diagnostic modalities, Adv. Drug Deliv. Rev., 2006, 58, 1456–1459
Meo C.D., Panza L., Capitani D., Mannina L., Banzato A., Rondina M. et al., Hyaluronan as carrier of carboranes for tumor targeting in boron neutron capture therapy, Biomacromolecules, 2007, 2, 552–559
Choia K.Y., Saravanakumarc G., Park J.H., Park K., Hyaluronic acid-based nanocarriers for intracellular targeting: Interfacial interactions with proteins in cancer, Colloids Surf. B. Biointerfaces, 2012, 99, 82–94
Stamenkovic I., Aruffo A., Amiot M., Seed B., The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells, EMBO J., 1991, 10, 343–348
Hien N.Q., Van Phu D., Duy N.N., Quoc L.A., Radiation synthesis and characterization of hyaluronan capped gold nanoparticles, Carbohydrate Polymers, 2012, 89, 537–541
Koryakin S. N., Ivanov P. L., Khabarov V. N., Yadrovskaya V.A., Isaeva E.V., Beketov E.E. et al. The synthesis and study of new compound hyaluronic acid-based and boron-10 for neutron capture therapy, Khimiko-Farmatsevticheskii Zhurnal, 2013, 47,6, 14–18 (in Russian)
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Koryakin, S.N., Yadrovskaya, V.A., Beketov, E.E. et al. The study of hyaluronic acid compounds for neutron capture and photon activation therapies. cent.eur.j.biol. 9, 922–930 (2014). https://doi.org/10.2478/s11535-014-0329-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.2478/s11535-014-0329-7