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Central European Journal of Biology

, Volume 8, Issue 8, pp 713–723 | Cite as

Effect of APOE polymorphism on obesity and lipid profile in women of differing reproductive status

  • Lenka Luptákova
  • Daniela Siváková
  • Marta Cvíčelová
Research Article

Abstract

The aim of this study was to investigate whether the effect of apolipoprotein E polymorphism (APOE) on somatic and lipid risk parameters varies in women of differing reproductive status. We analyzed 447 Slovak women aged between 39 and 90 years. APOE genotypes were determined by PCR-RFLP. Regression analysis confirmed the effect of the APOE genotype on the levels of LDL-cholesterol, apolipoprotein B (apoB), nonHDL-cholesterol and on the three atherogenic indices: apoB-to-apoA1, TC-to-HDLcholesterol, LDL-C-to-HDL-cholesterol. Here, lower mean levels were registered in the E2 carriers than in the E3 and E4 subgroups. However, the impact of menopausal status on lipid parameters was not confirmed. Bonferroni correction showed that systolic blood pressure was significantly lower in the E4 carriers compared to the E3 group (P=0.017). Univariate analysis of covariance revealed a significant interaction between the menopausal group and the APOE group, and their common effect on waist-to-hipratio (WHR). Bonferroni correction in early postmenopausal women showed that the mean WHR values were significantly different between E2 and E4 groups (P=0.008). This study demonstrates that the E*2 allele has a protective effect against higher blood lipid levels. Moreover, the results suggest that E*2 could have a partial negative effect on WHR in early postmenopausal Slovak women.

Keywords

Apolipoprotein E gene Menopause Anthropometric parameters Lipid levels 

Abbreviations

ANCOVA

univariate analysis of covariance

APOE

apolipoprotein E

apoB

apolipoprotein B

apoA1

apolipoprotein A1

BMI

body mass index

dBP

diastolic BP

DHEA

dehydroepiandrosterone

FMP

final menstrual period

HC

hip circumference

HDL-C

high density lipoprotein cholesterol

LDL-C

low density lipoprotein cholesterol

sBP

systolic blood pressure

TC

total cholesterol

TG

triglycerides

WC

waist circumference

WHR

waist to hip ratio

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Copyright information

© Versita Warsaw and Springer-Verlag Wien 2013

Authors and Affiliations

  • Lenka Luptákova
    • 1
  • Daniela Siváková
    • 1
  • Marta Cvíčelová
    • 1
  1. 1.Department of Anthropology, Faculty of Natural SciencesComenius UniversityBratislavaSlovakia

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