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Effect of APOE polymorphism on obesity and lipid profile in women of differing reproductive status

  • Research Article
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Central European Journal of Biology

Abstract

The aim of this study was to investigate whether the effect of apolipoprotein E polymorphism (APOE) on somatic and lipid risk parameters varies in women of differing reproductive status. We analyzed 447 Slovak women aged between 39 and 90 years. APOE genotypes were determined by PCR-RFLP. Regression analysis confirmed the effect of the APOE genotype on the levels of LDL-cholesterol, apolipoprotein B (apoB), nonHDL-cholesterol and on the three atherogenic indices: apoB-to-apoA1, TC-to-HDLcholesterol, LDL-C-to-HDL-cholesterol. Here, lower mean levels were registered in the E2 carriers than in the E3 and E4 subgroups. However, the impact of menopausal status on lipid parameters was not confirmed. Bonferroni correction showed that systolic blood pressure was significantly lower in the E4 carriers compared to the E3 group (P=0.017). Univariate analysis of covariance revealed a significant interaction between the menopausal group and the APOE group, and their common effect on waist-to-hipratio (WHR). Bonferroni correction in early postmenopausal women showed that the mean WHR values were significantly different between E2 and E4 groups (P=0.008). This study demonstrates that the E*2 allele has a protective effect against higher blood lipid levels. Moreover, the results suggest that E*2 could have a partial negative effect on WHR in early postmenopausal Slovak women.

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Abbreviations

ANCOVA:

univariate analysis of covariance

APOE:

apolipoprotein E

apoB:

apolipoprotein B

apoA1:

apolipoprotein A1

BMI:

body mass index

dBP:

diastolic BP

DHEA:

dehydroepiandrosterone

FMP:

final menstrual period

HC:

hip circumference

HDL-C:

high density lipoprotein cholesterol

LDL-C:

low density lipoprotein cholesterol

sBP:

systolic blood pressure

TC:

total cholesterol

TG:

triglycerides

WC:

waist circumference

WHR:

waist to hip ratio

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Authors and Affiliations

  1. Department of Anthropology, Faculty of Natural Sciences, Comenius University, 842 15, Bratislava, Slovakia

    Lenka Luptákova, Daniela Siváková & Marta Cvíčelová

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  1. Lenka Luptákova
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  2. Daniela Siváková
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  3. Marta Cvíčelová
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Correspondence to Lenka Luptákova.

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Luptákova, L., Siváková, D. & Cvíčelová, M. Effect of APOE polymorphism on obesity and lipid profile in women of differing reproductive status. cent.eur.j.biol. 8, 713–723 (2013). https://doi.org/10.2478/s11535-013-0192-3

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  • DOI: https://doi.org/10.2478/s11535-013-0192-3

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