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Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy

  • Research Article
  • Published:
Central European Journal of Biology

Abstract

A considerable variability in the incidence and prevalence of diabetic nephropathy (DN) coheres with an important contribution of multigenetic predisposition in the development of DN. Some genes, which probably participate in the pathogenesis of diabetic nephropathy, also play a role in the regulation of blood pressure, familial hyperlipidemia, familial hypertension and other diseases of the cardiovascular system. We have examined the association of diabetic nephropathy, nephropathy of non-diabetic origin, hypertension and of type 2 diabetes itself with several genetic polymorphisms (the insertion/deletion polymorphism in the gene for angiotensin-converting enzyme, the G/T polymorphism in the glucose transporter 1 gene, the G/T (894) polymorphism and the T/C (−786) polymorphism in the eNOS gene in three groups of patients with diabetes mellitus: 1) patients without diabetic nephropathy (DM); 2) patients with DN; 3) patients with nephropathy of non-diabetic origin (NDRD). Angiotensin-converting enzyme is an important factor in a development of arterial hypertension, but in our groups of Central European diabetic patients the I/D polymorphism was not associated with diabetic nephropathy. Furthermore, we have confirmed that the T/C (T786C) polymorphism in the eNOS gene is associated with metabolic syndrome including type 2 diabetes.

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Authors and Affiliations

  1. Department of General Biology and Genetics, 3rd Faculty of Medicine, Charles University, 100 00, Prague, Czech Republic

    Hana Demova, Jana Boleckova & Marie Cerna

  2. 5th Medical Department, Medical Faculty Mannheim, University Heidelberg, 69047, Mannheim, Germany

    Daniela Rose & Hannes Koeppel

  3. Department of Scientific Information and Biostatistics, National Institute of Public Health, 100 42, Prague, Czech Republic

    Bohumir Prochazka

  4. 2nd Department of Internal Medicine, 3rd Faculty of Medicine, Charles University, 100 00, Prague, Czech Republic

    Ludmila Brunerova & Ivan Rychlik

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  1. Hana Demova
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Demova, H., Boleckova, J., Rose, D. et al. Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy. cent.eur.j.biol. 7, 210–218 (2012). https://doi.org/10.2478/s11535-012-0003-x

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