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Inducing stem cell differentiation using low intensity laser irradiation: a possible novel therapeutic intervention

Abstract

Developments in adult stem cell (ASC) potentiation have contributed to excitement in the field of stem cell-based therapy. The use of ASCs not only increases therapeutic treatment possibilities but successful use of multipotent cells for gene therapy has been demonstrated in animal models [1]. Concurrent ability of stem cells (SCs) to either contribute to disease development, as identified in cancer stem cells (CSCs), or to replace diseased tissue by induced differentiation using selected growth factors, has highlighted the intricate molecular and cellular mechanisms. Adipose derived stem cells (ADSCs) are capable of self-renewal and respond well to induced differentiation [2]. Auto-immunity and transplant rejection may become minor limitations when selective induction of immunological nonresponsiveness to specific antigens or tissues become possible using autologous cell sources [3]. CSCs initiate tumorogenesis, can generate differentiated daughter cells or undergo self-renewal while thought to instigate tumour regeneration post-treatment. Therapy targeting CSCs has failed to provide feasible alternatives to conventional cancer treatment. Low intensity laser irradiation (LILI), induce a biostimulatory response in several tissue types in addition to a dose-response effect to the detriment of cellular degeneration. Potential of LILI to induce CSC differentiation and subsequent cytotoxic therapy to prevent tumour regeneration is explored in this mini-review.

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References

  1. Rizvi A.Z., Swain J.R., Davies P.S., Bailey A.S., Decker A.D., Willenbring M.G., et al., Bone marrow-derived cells fuse with normal and transformed intestinal stem cells, PNAS, 2006, 103, 6321–6325

    PubMed  Article  CAS  Google Scholar 

  2. Tarnok A., Ulrich H., Bocsi J., Phenotypes of Stem Cells from Diverse Origin, Cytometry, 2010, 77A, 6–10

    Article  Google Scholar 

  3. Ichim T.E., Harman R.J., Min W., Minev B., Solano F., Rodriguez J.P., et al., Autologous stromal vascular fraction cells: A tool for facilitating tolerance in rheumatic disease, Cell. Immunol., 2010, 264, 7–17

    PubMed  Article  CAS  Google Scholar 

  4. De Villiers J.A., Houreld N.N., Abrahamse H., Adipose Derived Stem Cells and Smooth muscle Cells: Implications for Regenerative Medicine, Stem Cell Rev and Rep, 2009, 5, 256–265

    Article  Google Scholar 

  5. Strem B. M., Hicok K. C., Zhu M., Wulur I., Alfonso Z., Schreiber R. E., et al., Multipotential differentiation of adipose tissue-derived stem cells, Keio J Med, 2005, 54, 132–141

    PubMed  Article  CAS  Google Scholar 

  6. Zuk P. A., Zhu M., Ashjian P., De Ugarte D. A., Huang J. I., Mizuno H., et al., Human adipose tissue is a source of multipotent stemcells, Mol Biol Cell, 2002, 13, 4279–4295

    PubMed  Article  CAS  Google Scholar 

  7. Fraser J. K., Wulur I., Alfonso Z., Hedrick M. H., Fat tissue: an underappreciated source of stem cells for biotechnology, Trends Biotech, 2006, 24, 150–154

    Article  CAS  Google Scholar 

  8. Schäffler A., Büchler C., Concise review: adipose tissue-derived stromal cells-basic and clinical implications for novel cell-based therapies, Stem Cells, 2008, 25, 818–827

    Article  Google Scholar 

  9. Alison M.R., Lim S.M.L., Nicholson L.J., Cancer stem cells: problems for therapy?, J Pathol, 2011, 223, 147–161

    PubMed  Article  CAS  Google Scholar 

  10. Tomasson M.H., Cancer Stem Cells: A Guide for Skeptics, J Cell Biochem, 2009, 106, 745–749

    PubMed  Article  CAS  Google Scholar 

  11. Hamburger A.W., Salmon S.E., Primary bioassay of human tumor stem cells, Science, 1977, 197, 461–463

    PubMed  Article  CAS  Google Scholar 

  12. Gao X., Xing D., Molecular mechanisms of cell proliferation induced by low power laser irradiation, J Biomed Sci, 2009, 16, 1–16

    Article  CAS  Google Scholar 

  13. Gasparyan L., Brill G., Makela A., Influence of low level laser radiation on migration of stem cells, Laser Florence, 2004, 1–7

  14. Mvula B., Moore T.J., Abrahamse H., Effect of lowlevel laser irradiation and epidermal growth factor on adult human adipose-derived stem cells, Lasers Med. Sci, 2010, 25, 33–39

    PubMed  Article  CAS  Google Scholar 

  15. Tuby H., Maltz L., Oron U., Low level laser irradiation (LLLI) promotes proliferation of mesenchymal and cardiac stem cells in culture, Lasers Surg Med, 2007, 39, 373–378

    PubMed  Article  Google Scholar 

  16. Anders J. J., Romanczyk T. B., Ilev I. K., Moges H., Longo L., Wu Xingjia et al., Selected Topics in Quantum Electronics, IEEE, J Sel Top Quant Electron, 2008, 14, 118–125

    Article  CAS  Google Scholar 

  17. De Villiers J., Houreld N.N., Abrahamse H., Influence of Low Intensity Laser Irradiation on Isolated Human Adipose Derived Stem Cells Over 72 Hours and Their Differentiation Potential into Smooth Muscle Cells Using Retinoic Acid, Stem Cell Rev and Rep, 2011, (In Press), DOI 10.1007/s12015-011-9244-8

  18. Abrahamse H., Houreld N.N., Muller S., Ndlovu L., Fluence and Wavelength of Low Intensity Laser Irradiation affect activity and proliferation of human Adipose Derived Stem Cells, Medtech SA, 2010, 24, 8–14

    Google Scholar 

  19. Gimble J.M., Adipose tissue derived therapeutics, Opin Biol Ther, 2003, 3, 705–713

    Article  CAS  Google Scholar 

  20. Diehn M., Cho R.W., Clarke M.F., Therapeutic Implications of the Cancer Stem Cell Hypothesis, Semin Radiat Oncol, 2009, 19, 78–86

    PubMed  Article  Google Scholar 

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Correspondence to Heidi Abrahamse.

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Abrahamse, H. Inducing stem cell differentiation using low intensity laser irradiation: a possible novel therapeutic intervention. cent.eur.j.biol. 6, 695 (2011). https://doi.org/10.2478/s11535-011-0068-y

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  • DOI: https://doi.org/10.2478/s11535-011-0068-y

Keywords

  • Adipose derived stem cells
  • Autologous grafts
  • Cancer stem cells
  • Low Intensity Laser Irradiation