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An antioxidant probiotic reduces postprandial lipemia and oxidative stress

  • Research Article
  • Published:
Central European Journal of Biology

Abstract

Reducing postprandial oxidative stress (OxS), decreasing postprandial blood triglyceride level (TG) and improving lipoprotein status is likely to have a preventive impact on the development of cardiovascular disease (CVD). Previously we have shown that the antioxidant probiotic Lactobacillus fermentum ME-3 (DSM14241) is characterized by antiatherogenic effects. This randomized double-blind placebo-controlled study evaluated the influence of kefir enriched with an antioxidative probiotic L. fermentum ME-3 (LfKef) on postprandial OxS, blood TG response and lipoprotein status. 100 clinically healthy subjects were recruited into the study. Blood parameters of postprandial OxS, TG and lipoprotein status were determined by oxidized LDL, baseline diene conjugation in LDL (BDC-LDL), oxidized LDL complex with beta-2 glycoprotein (Beta2-GPI-oxLDL), paraoxonase (PON) activity, LDL-Chol, HDL-Chol and TG. To evaluate general body postprandial OxS-load we measured 8-isoprostanes (8-EPI) in the urine. Consumption of LfKef significantly reduced the postprandial level of oxidized LDL, BDC-LDL, Beta2-GPI-oxLDL, urinary 8-isoprostanes and postprandial TG and caused a significant increase in HDL-Chol and PON activity. This is the first evidence that kefir enriched with an antioxidant probiotic may have a positive effect on both postprandial OxS and TG response as well as on lipoprotein status.

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Author notes

  1. Tiiu Kullisaar

    Present address: Biomedicum, Department of Biochemistry, Faculty of Medicine, Tartu University, 50411, Tartu, Estonia

Authors and Affiliations

  1. Department of Biochemistry of Faculty of Medicine, Tartu University, 50411, Tartu, Estonia

    Tiiu Kullisaar, Kersti Zilmer, Aune Rehema & Mihkel Zilmer

  2. Department of Microbiology of Faculty of Medicine, Tartu University, 50411, Tartu, Estonia

    Jelena Shepetova & Marika Mikelsaar

  3. Bio-Competence Centre of Healthy Dairy Products, 50411, Tartu, Estonia

    Tiiu Kullisaar & Epp Songisepp

  4. The Centre of Excellence for Translational Medicine, 50411, Tartu, Estonia

    Tiiu Kullisaar, Kersti Zilmer, Aune Rehema & Mihkel Zilmer

Authors
  1. Tiiu Kullisaar
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  2. Jelena Shepetova
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Correspondence to Tiiu Kullisaar.

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Kullisaar, T., Shepetova, J., Zilmer, K. et al. An antioxidant probiotic reduces postprandial lipemia and oxidative stress. cent.eur.j.biol. 6, 32–40 (2011). https://doi.org/10.2478/s11535-010-0103-4

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  • DOI: https://doi.org/10.2478/s11535-010-0103-4

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