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Central European Journal of Biology

, Volume 6, Issue 1, pp 32–40 | Cite as

An antioxidant probiotic reduces postprandial lipemia and oxidative stress

  • Tiiu KullisaarEmail author
  • Jelena Shepetova
  • Kersti Zilmer
  • Epp Songisepp
  • Aune Rehema
  • Marika Mikelsaar
  • Mihkel Zilmer
Research Article

Abstract

Reducing postprandial oxidative stress (OxS), decreasing postprandial blood triglyceride level (TG) and improving lipoprotein status is likely to have a preventive impact on the development of cardiovascular disease (CVD). Previously we have shown that the antioxidant probiotic Lactobacillus fermentum ME-3 (DSM14241) is characterized by antiatherogenic effects. This randomized double-blind placebo-controlled study evaluated the influence of kefir enriched with an antioxidative probiotic L. fermentum ME-3 (LfKef) on postprandial OxS, blood TG response and lipoprotein status. 100 clinically healthy subjects were recruited into the study. Blood parameters of postprandial OxS, TG and lipoprotein status were determined by oxidized LDL, baseline diene conjugation in LDL (BDC-LDL), oxidized LDL complex with beta-2 glycoprotein (Beta2-GPI-oxLDL), paraoxonase (PON) activity, LDL-Chol, HDL-Chol and TG. To evaluate general body postprandial OxS-load we measured 8-isoprostanes (8-EPI) in the urine. Consumption of LfKef significantly reduced the postprandial level of oxidized LDL, BDC-LDL, Beta2-GPI-oxLDL, urinary 8-isoprostanes and postprandial TG and caused a significant increase in HDL-Chol and PON activity. This is the first evidence that kefir enriched with an antioxidant probiotic may have a positive effect on both postprandial OxS and TG response as well as on lipoprotein status.

Keywords

Postprandial period Oxidative stress Postprandial lipemic response Probiotics Lactobacillus fermentum Oxidized low-density lipoprotein Paraoxonase, isoprostanes 

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Copyright information

© © Versita Warsaw and Springer-Verlag Wien 2010

Authors and Affiliations

  • Tiiu Kullisaar
    • 1
    • 3
    • 4
    Email author
  • Jelena Shepetova
    • 2
  • Kersti Zilmer
    • 1
    • 4
  • Epp Songisepp
    • 3
  • Aune Rehema
    • 1
    • 4
  • Marika Mikelsaar
    • 2
  • Mihkel Zilmer
    • 1
    • 4
  1. 1.Department of Biochemistry of Faculty of MedicineTartu UniversityTartuEstonia
  2. 2.Department of Microbiology of Faculty of MedicineTartu UniversityTartuEstonia
  3. 3.Bio-Competence Centre of Healthy Dairy ProductsTartuEstonia
  4. 4.The Centre of Excellence for Translational MedicineTartuEstonia

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