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CLERC and centrosomal leucine-rich repeat proteins

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Central European Journal of Biology

Abstract

The centrosome functions as the microtubule-organizing center and plays a vital role in organizing spindle poles during mitosis. Recently, we identified a centrosomal protein called CLERC (Centrosomal leucine-rich repeat and coiled-coil containing protein) which is a human ortholog of Chlamydomonas Vfl1 protein. The bibliography as well as database searches provided evidence that the human proteome contains at least seven centrosomal leucine-rich repeat proteins including CLERC. CLERC and four other centrosomal leucine-rich repeat proteins contain the SDS22-like leucine-rich repeat motifs, whereas the remaining two proteins contain the RI-like and the cysteine-containing leucine-rich repeat motifs. Individual leucine-rich repeat motifs are highly conserved and present in evolutionarily diverse organisms. Here, we provide an overview of CLERC and other centrosomal leucine-rich repeat proteins, their structures, their evolutionary relationships, and their functional properties.

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  1. Department of Functional Bioscience, Gifu University School of Medicine, 501-1193, Gifu, Japan

    Yoshinori Muto

  2. Department of Molecular Pathobiochemistry, Gifu University Graduate School of Medicine, 501-1194, Gifu, Japan

    Yukio Okano

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  1. Yoshinori Muto
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  2. Yukio Okano
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Correspondence to Yoshinori Muto.

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Muto, Y., Okano, Y. CLERC and centrosomal leucine-rich repeat proteins. cent.eur.j.biol. 5, 1–10 (2010). https://doi.org/10.2478/s11535-009-0061-x

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